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2005 Progress Report: Cardiopulmonary Effects of Metal-Containing Particulate Exposure
EPA Grant Number: R828678C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R824834
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Mickey Leland National Urban Air Toxics Research Center (NUATRC)
Center Director: Beskid, Craig
Title: Cardiopulmonary Effects of Metal-Containing Particulate Exposure
Investigators: Christiani, David
Current Investigators: Christiani, David , Hauser, Russ , Herrick, Robert , Kim, Jee Young , Magari, Shannon , Smith, Thomas , Wand, Matthew , Williams, Paige L.
Institution: Harvard School of Public Health
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: January 1, 1999 through January 31, 2004
Project Period Covered by this Report: January 1, 2004 through January 31, 2005
RFA: Mickey Leland National Urban Air Toxics Research Center (NUATRC) (1997)
Research Category: Targeted Research , Air Quality and Air Toxics
Description:
Objective:The objective of this research project is to investigate the role of respirable particulate matter (PM2.5) and associated metals in respiratory and cardiovascular responses in a cohort of boilermakers with and without chronic bronchitis. The experimental approach was an epidemiological study employing a prospective, repeat-measurement design assessing several biological parameters in relation to exposure. PM2.5 levels were monitored continuously with personal Dust Trak monitors. Personal metal exposure (V, N, Cd, Mn, Cr, and Fe) was measured daily.
The study’s three specific aims and corresponding hypotheses were as follows:
- Conduct a short-term prospective study of acute airway responses to combustion particulates.
Hypothesis: Exposure to fuel-oil ash particulates induces airway inflammation and airflow obstruction, as reflected in increased expired NO and in decreases in forced expiratory volume. - Conduct a short-term prospective study of acute cardiovascular responses to combustion particulates.
Hypothesis: Exposure to fuel-oil ash particulates will result in acute changes in cardiovascular function as reflected in changes in heart rate (HR) and heart rate variability (HRV). Changes in HR and HRV will be in a direction believed to reflect increased sympathetic or decreased vagal tone. - Assess the relationship between chronic respiratory disease and the cardiac responses to particulates.
Hypothesis: Chronic bronchitis predisposes particulate-exposed workers to changes in cardiac function, including HR and HRV.
This project was developed in response to National Urban Air Toxics Research Center (NUATRC) Request for Application 98-02, “Contribution of Metals in Ambient Particles to the Particulate Associated Health Effects.” The study is in compliance with the Institutional Review Board of the Harvard School of Public Health. Human consent procedures met governmental guidelines. The study also is in compliance with appropriate quality control and quality assurance procedures as per NUATRC and U.S. Environmental Protection Agency guidelines. A draft Final Report for the study was received at the NUATRC in December 2002. The report was reviewed by a team of external peer-reviewers and the NUATRC Scientific Advisory Panel (SAP). The external reviewers’ and SAP’s comments were addressed by Dr. Christiani in a revised Final Report. The revised Final Report was received by the NUATRC on September 8, 2003, and has been reviewed by the SAP. The statement of the SAP was finalized and approved at the October 2005 SAP meeting. The SAP and Board of Directors approved publication of the report after a Statement by the SAP, which provides alternate interpretation of the study results presented by Dr. Christiani. The Report has been edited by the technical editor and is expected to be published in February.
Future Activities:Publication of the final report.
Journal Articles on this Report: 6 Displayed | Download in RIS Format
| Other subproject views: | All 11 publications | 6 publications in selected types | All 6 journal articles |
| Other center views: | All 122 publications | 54 publications in selected types | All 46 journal articles |
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Kim JY, Wand MP, Hauser R, Mukherjee S, Herrick RF, Christiani DC. Association of expired nitric oxide with occupational particulate exposure. Environmental Health Perspectives 2003;111(5):676-680. |
R828678C002 (2002) R828678C002 (2003) R828678C002 (2004) R828678C002 (2005) R828678C002 (2006) |
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Kim JY, Hauser R, Wand MP, Herrick RF, Houk RS, Aeschliman DB, Woodin MA, Christiani DC. Association of expired nitric oxide with urinary metal concentrations in boilermakers exposed to residual oil fly ash. American Journal of Industrial Medicine 2003;44(5):458-466. |
R828678C002 (2005) R828678C002 (2006) |
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Kim JY, Hauser R, Wand MP, Herrick RF, Amarasiriwardena CJ, Christiani DC. The association of expired nitric oxide with occupational particulate metal exposure. Environmental Research 2003;93(2):158-166. |
R828678C002 (2004) R828678C002 (2005) R828678C002 (2006) |
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Magari SR, Hauser R, Schwartz J, Williams PL, Smith TJ, Christiani DC. Association of heart rate variability with occupational and environmental exposure to particulate air pollution. Circulation 2001;104(9):986-991. |
R828678C002 (2001) R828678C002 (2003) R828678C002 (2004) R828678C002 (2005) R828678C002 (2006) R827353 (Final) |
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Magari SR, Schwartz J, Williams PL, Hauser R, Smith TJ, Christiani DC. The association between personal measurements of environmental exposure to particulates and heart rate variability. Epidemiology 2002;13(3):305-310. |
R828678C002 (2002) R828678C002 (2003) R828678C002 (2004) R828678C002 (2005) R828678C002 (2006) |
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Magari SR, Schwartz J, Williams PL, Hauser R, Smith TJ, Christiani DC. The association of particulate air metal concentrations with heart rate variability. Environmental Health Perspectives 2002;110(9):875-880. |
R828678C002 (2002) R828678C002 (2003) R828678C002 (2004) R828678C002 (2005) R828678C002 (2006) |
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Air pollution, urban, monitoring, exposure, methods, indoor air, volatile organic compounds, VOCs, particulate matter, PM, environmental policy, exposure, health risk assessment, physical processes, risk assessments, susceptibility/sensitive population/genetic susceptibility, air toxics, genetic susceptibility, acute health effects, acute cardiovascular effects, acute exposure, acute lung injury, air contaminant exposure, air quality, airborne urban contaminants, airway disease, aldehydes, assessment of exposure, atmospheric particulate matter, cardiac arrest, cardiopulmonary response, children, children’s environmental health, chronic health effects, copollutants, copollutant exposures, environmental hazard exposures, fine particles, health effects, human exposure, human health risk, human susceptibility, inhaled pollutants, long-term exposure, lung inflammation, particulate exposure, sensitive populations, susceptible subpopulations, toxics,
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HUMAN HEALTH, Air, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Biology, Risk Assessments, genetic susceptability, Health Risk Assessment, air toxics, Atmospheric Sciences, particulate matter, Environmental Chemistry, Exposure, cardiopulmonary, chemical mixtures, environmental hazard exposures, airborne urban contaminants, acute exposure, Acute health effects, cardiovascular disease, mortality, air contaminant exposure, co-pollutants, cardiac arrest, air quality, cardiopulmonary response, cardiotoxicity, fine particles, cardiopulmonary responses, human health risk, lung inflammation, toxics, acute cardiovascular effects, chronic health effects, PM 2.5, sensitive populations, acute lung injury, air pollution, inhaled, atmospheric particulate matter, National Cohort Studies, copollutant exposures, susceptible subpopulations, long term exposure, human susceptibility, time series analysis, human exposure, morbidity, particulate exposure
Relevant Websites:
http://www.sph.uth.tmc.edu/mleland/
Progress and Final Reports:
2001 Progress Report
2002 Progress Report
2003 Progress Report
2004 Progress Report
Original Abstract
2006 Progress Report
Main Center Abstract and Reports:
R824834 Mickey Leland National Urban Air Toxics Research Center (NUATRC)
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R824834C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles - A Columbia-Harvard Study (TEACH)
R824834C002 Cardiopulmonary Response to Particulate Exposure
R824834C003 VOC Exposure in an Industry Impacted Community
R824834C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
R824834C005 Methods Development Project for a Study of Personal Exposures to Toxic Air Pollutants
R824834C006 Relationship Between Indoor, Outdoor and Personal Air (RIOPA)
R824834C007 Development of the "Leland Legacy" Air Sampling Pump
R824834C008 Source Apportionment of Indoor Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Residences
R824834C009 Development of a Personal Cascade Impactor Sampler (PCIS)
R824834C010 Testing the Metals Hypothesis in Spokane
R828678C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles—A Columbia-Harvard Study (TEACH)
R828678C002 Cardiopulmonary Effects of Metal-Containing Particulate Exposure
R828678C003 VOC Exposure in an Industry Impacted Community
R828678C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
R828678C005 Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)
R828678C006 Relationship between Indoor, Outdoor and Personal Air (RIOPA). Part II: Analyses of Concentrations of Particulate Matter Species
R828678C007 Development of the “Leland Legacy” Air Sampling Pump
R828678C008 Source Apportionment of Indoor PAHs in Urban Residences 98-03B
R828678C009 Development of a Personal Cascade Impactor Sampler (PCIS)
R828678C010 Testing the Metals Hypothesis in Spokane
R828678C011 A Pilot Geospatial Analysis of Exposure to Air Pollutants (with Special Attention to Air Toxics) and Hospital Admissions in Harris County, Texas
R828678C012 Impact of Exposure to Urban Air Toxics on Asthma Utilization for the Pediatric Medicaid Population in Dearborn, Michigan
R828678C013 Field Validation of the Sioutas Sampler and Leland Legacy Pump – Joint Project with EPA’s Environmental Technology Validation Program (ETV)
R828678C014 Performance Evaluation of the 3M Charcoal Vapor Monitor for Monitor Low Ambient Concentrations of VOCs
R828678C015 RIOPA Database Development
R828678C016 Contributions of Outdoor PM Sources to Indoor and Personal Exposures: Analysis of PM Species Concentrations” Focused on the PM Speciation and Apportioning of Sources
R828678C017 The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children