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Research Centers
University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment
University of Medicine and Dentistry of New Jersey
The main focus of the UMDNJ Children’s Center, established in 2002, is to examine the effects of environmental chemicals on neurological health and development, with an emphasis on the interaction between exposure to environmental factors, learning disabilities and autism spectrum disorders (ASD). Investigators at the UMDNJ Children’s Center have developed important basic and clinical science data, which has had a significant impact in the field.
The causes and contributing factors for ASD are poorly understood. Evidence suggests that incidence of ASD is increasing, now estimated at 1 in every 150 births, and the rate is higher for male children. Most cases seem likely to arise from a combination of an ever increasing array of genetic factors and additional environmental factors, while diagnostic changes and improvements may also be contributing to the increased rates.
Projects at the UMDNJ Children’s Center include developing animal models of features of autism such as regression of neurobehavioral function or self-injurious behavior, and developing animal models mimicking the genes linked to autism in humans. Through clinical studies of children with autism, the UMDNJ Center is also examining whether certain biochemical and genetic characteristics of autistic children, demonstrate that select children with autism have increased susceptibility to chemical induced neurobehavioral dysfunction. such as loss of neurobehavioral function may be related to exposure to environmental neurotoxins, perhaps in combination with specific genetic predispositions, creating a gene-environment interaction. With the identification of the genetic and biochemical susceptibility factors the goal will be to develop individualized therapeutic interventional strategies. The overall mission of the Center is to improve the environmental and public health of children through research, assessment, treatment and outreach.
Center Publications:
| Views: | All publications | Selected publication types | Journal articles | Publications submitted after final report |
| Identifier | Abstract | Principal Investigator | Annual/ Final Reports | Pubs Count | Institution | Grant Representative | Grant Amount | Project Period | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
R829391 Centers - Main center abstract - CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment |
Center for Childhood Neurotoxicology and Assessment |
Lambert, George H. Lu, Shou-En Reuhl, Kenneth R. Spencer, Stephanie - Principal Investigators listed are sub-PIs determined by the center. |
2004
|
Total Pubs:
88 Journals: 51 -- No Books -- |
University of Medicine and Dentistry of New Jersey |
Fields, Nigel |
$6,751,466 |
November 2001 - October 2006 |
| 2 |
R829391C001 Centers - This is a subproject of the CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment |
Neurotoxicant Effects on Cell Cycle Regulation of Neurogenesis |
DiCicco-Bloom, Emanuel - Principal Investigators listed are sub-PIs determined by the center. |
2004
|
Total Pubs:
8 Journals: 2 -- No Books -- |
University of Medicine and Dentistry of New Jersey |
EPA Project Officer(s) for CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment Grant Number R829391: Fields, Nigel |
Refer to main center abstract for funding details. |
November 2001 - October 2006 |
| 3 |
R829391C002 Centers - This is a subproject of the CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment |
Adhesion and Repulsion Molecules in Developmental Neurotoxic Injury |
Reuhl, Kenneth R. - Principal Investigators listed are sub-PIs determined by the center. |
2004
|
Total Pubs:
23 Journals: 9 -- No Books -- |
University of Medicine and Dentistry of New Jersey |
EPA Project Officer(s) for CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment Grant Number R829391: Fields, Nigel |
Refer to main center abstract for funding details. |
November 2001 - October 2006 |
| 4 |
R829391C003 Centers - This is a subproject of the CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment |
Disruption of Ontogenic Development of Cognitive and Sensory Motor Skills |
Wagner, George - Principal Investigators listed are sub-PIs determined by the center. |
2004
|
Total Pubs:
21 Journals: 9 -- No Books -- |
University of Medicine and Dentistry of New Jersey |
EPA Project Officer(s) for CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment Grant Number R829391: Fields, Nigel |
Refer to main center abstract for funding details. |
November 2001 - October 2006 |
| 5 |
R829391C004 Centers - This is a subproject of the CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment |
Exposure Assessment and Intervention Project (EAIP) |
Lioy, Paul J. Georgopoulos, Panos G. Shalat, Stuart L. Weisel, Clifford P. - Principal Investigators listed are sub-PIs determined by the center. |
2004
|
Total Pubs:
13 Journals: 9 -- No Books -- |
University of Medicine and Dentistry of New Jersey |
EPA Project Officer(s) for CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment Grant Number R829391: Fields, Nigel |
Refer to main center abstract for funding details. |
November 2001 - October 2006 |
| 6 |
R829391C005 Centers - This is a subproject of the CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment |
Clinical Sciences Project |
Lambert, George H. Johnson, William Mars, Audrey Moreno, Rosanne Seshadri, Kapila Carmody, Dennis - Principal Investigators listed are sub-PIs determined by the center. |
2004
|
Total Pubs:
9 Journals: 8 -- No Books -- |
University of Medicine and Dentistry of New Jersey |
EPA Project Officer(s) for CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment Grant Number R829391: Fields, Nigel |
Refer to main center abstract for funding details. |
November 2001 - October 2006 |