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Mechanistic Research Project
EPA Grant Number: R832141C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R832141
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: Mechanistic Research Project
Investigators: Rothman, Paul B. , Chen, Lung Chi , Grunig, Gabriele , Miller, Rachel L.
Current Investigators: Rothman, Paul B.
Institution: Columbia University , New York University
Current Institution: Columbia University
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2003 through October 31, 2008
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Health Effects , Children's Health
Description:
Objective:The specific objectives of this research project are to determine whether: (1) in utero sensitization increases the risk for subsequent airway hyperreactivity and antigen-induced inflammation; (2) diesel exhaust particles, endemic to the Northern Manhattan environment, promote antigen-specific prenatal sensitization, if this occurs by upregulating Th2-mediated allergic responses, and if polycyclic aromatic hydrocarbons (PAHs), measured by PAH-adducts in lung tissue, mediates this response; and (3) endotoxin protects from the development of antigen-specific prenatal sensitization, and whether this occurs by upregulating Th1-mediated immune processes.
Supplemental Keywords:children’s health, genetics, health effects, health risk assessment, assessment of exposure, endotoxins, PAHs, OVA, environmental risks, environmental exposure, exposure assessment, genetic risk factors, genetic susceptibility, maternal exposure, nutritional risk factors, diesel exhaust,
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ENVIRONMENTAL MANAGEMENT, INTERNATIONAL COOPERATION, Air, Scientific Discipline, Health, RFA, Risk Assessment, Health Risk Assessment, air toxics, Children's Health, Biochemistry, Environmental Policy, Genetics, exposure assessment, health effects, genetic risk factors, children's environmental health, diesel exhaust, assessment of exposure, genetic susceptibility, maternal exposure, diesel exhaust particulate, nutritional risk factors, genetic mechanisms, environmental risks, PAH
Progress and Final Reports:
2004 Progress Report
2005 Progress Report
2006 Progress Report
Main Center Abstract and Reports:
R832141 Columbia Center for Children’s Environmental Health
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832141C001 Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
R832141C002 Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
R832141C003 Mechanistic Research Project
R832141C004 Community-Based Intervention Project: Reduction of Exposure and Risk from Pesticides and Allergens
R832141C005 Community Translation and Application Core (COTAC)
R832141C006 Exposure Assessment Facility Core
R832141C007 Data Management, Statistics and Community Impact Modeling Core
R832141C008 Administrative Core