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Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma

EPA Grant Number: R832141C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R832141
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
Investigators: Rothman, Paul B. , Barr, R. Graham , Goldstein, Inge , Lederman, Sally Ann , Miller, Rachel L. , Sheares, Beverly
Current Investigators: Rothman, Paul B.
Institution: Columbia University
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2003 through October 31, 2008
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Health Effects , Children's Health

Description:

Objective:

The specific objectives of this research project are to: (1) determine the relationship between environmental exposures experienced prenatally through early childhood and atopy and adverse respiratory outcomes and asthma at age 5-7 years; (2) determine the interaction between susceptibility factors and environmental exposures on respiratory outcomes and asthma through age 5-7 years; (3) determine whether antigen-induced cord blood mononuclear cell proliferation or cytokine production increases the risk for decreased lung function or atopy at age 5 years among children with physician diagnosis of probable asthma at age 2 years or allergen-specific IgE levels at ages 2 and 3 years are associated with decreased lung function or atopy at age 5 years; and (4) collaborate with the Community Outreach, Translation and Application Core to ensure that asthma risk factors of concern to the community are being addressed, translate research findings back to the community, and assist in developing interventions and policies to prevent exposures that contribute to asthma and adverse respiratory health in New York City and elsewhere.

Publications and Presentations:

Publications have been submitted on this subproject: View all 2 publications for this subproject | View all 100 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 2 journal articles for this subproject | View all 86 journal articles for this center

Supplemental Keywords:

children’s health, health effects, health risk assessment, asthma, genetics, assessment of exposure, PAH, ETS, environmental risks, environmental exposure, exposure assessment, genetic risk factors, genetic susceptibility, maternal exposure, nutritional risk factors, , HUMAN HEALTH, ENVIRONMENTAL MANAGEMENT, Scientific Discipline, Health, RFA, Health Effects, Risk Assessment, Health Risk Assessment, Epidemiology, Children's Health, Biochemistry, Genetics, exposure assessment, genetic risk factors, children's environmental health, diesel exhaust, assessment of exposure, prenatal exposure, genetic susceptibility, maternal exposure, nutritional risk factors, genetic mechanisms, environmental risks, asthma

Progress and Final Reports:
2004 Progress Report
2005 Progress Report
2006 Progress Report


Main Center Abstract and Reports:
R832141    Columbia Center for Children’s Environmental Health

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832141C001 Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
R832141C002 Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
R832141C003 Mechanistic Research Project
R832141C004 Community-Based Intervention Project: Reduction of Exposure and Risk from Pesticides and Allergens
R832141C005 Community Translation and Application Core (COTAC)
R832141C006 Exposure Assessment Facility Core
R832141C007 Data Management, Statistics and Community Impact Modeling Core
R832141C008 Administrative Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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