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Columbia Center for Children's Environmental Health
EPA Grant Number: R832141Center: Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: Columbia Center for Children's Environmental Health
Investigators: Perera, Frederica P.
Institution: Columbia University
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2003 through October 31, 2008
Project Amount: $4,435,198
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Health Effects , Children's Health
Description:
Objective:The new research will assess the relative effects of prenatal and postnatal exposures, combined or interactive effects of exposure to multiple urban contaminants, the time course of impairment and disease, and the modulating effects of social adversity and nutritional and genetic risk factors. Because the Center investigates both respiratory and developmental health effects of environmental exposures, we are uniquely positioned to study the multiple consequences of early exposures on child health and development, as well as the possible role of asthma, which is extremely common in our population, in influencing cognitive development. The three primary aims of the research are: a) to determine the relationships between prenatal and/or postnatal exposures and health; b) to determine the modulation of risks by susceptibility factors; and c) to translate research findings to prevention.
Approach:The Center will continue using molecular epidemiologic approaches to follow-up of the mother and child cohort through ages five to seven, as the children enter school, with links to school performance data at age eight. Additional exposure, biomarker, and outcome assessments will allow testing of new etiologic hypotheses for the asthma and growth and development research projects. A new laboratory-based mechanistic research project will elucidate possible mechanisms of in utero sensitization by co-exposure to PAH/diesel exhaust particles and allergens. An intervention project on integrated pest management and health-related housing improvements will be conducted in partnership with the New York City Departments of Health and Mental Health and the New York City Housing Authority. A new Community Outreach, Translation, and Application Core will ensure that the Center’s findings have local and national public health impact. Initiatives include educating medical students and obstetric and pediatric residents about children’s environmental health, a community campaign to improve air and housing quality in New York City, risk assessment analyses using Center findings.
Expected Results:The proposed etiologic projects will provide much-needed knowledge about the long-term risks of impairment due to environmental exposures in African American and Latino communities, in the context of nutritional and genetic susceptibilities and psychosocial stressors measured at the individual and community levels. The Center’s Data Core facilities will add a greatly expanded geographic information system to integrate multi-level data in spatial context . We expect that this comprehensive research will aid government agencies in setting environmental limits that protect the most susceptible members of the general population. The Mechanistic Research Project will determine the mechanisms by which prenatal exposures may increase risk of in utero sensitization and asthma, all found to occur commonly in our cohort, with potentially important implications for asthma prevention. The proposed intervention project will expand our partnership with NYCDOHMH and NYCHA to determine the efficacy of a comprehensive integrated pest management program for public housing that combines lower toxicity pesticides, physical repairs, and education to reduce pests over an extended period. This research will help our agency partners determine whether to implement integrated pest management throughout the public housing system.
Journal Articles: 86 Displayed | Download in RIS Format
| Other center views: | All 100 publications | 89 publications in selected types | All 86 journal articles |
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Adibi JJ, Perera FP, Jedrychowski W, Camaan DE, Barr D, Jacek R, Whyatt RM. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environmental Health Perspectives 2003;111(14):1719-1722. |
R832141 (2005) R832141 (2006) |
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Barr DB, Barr JR, Maggio VL, Whitehead RD Jr., Sadowski MA, Whyatt RM, Needham LL. A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high resolution mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2002;778(1-2):99-111. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Bocskay KA, Tang D, Orjuela MA, Liu X, Warburton DP, Perera FP. Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons. Cancer Epidemiology Biomarkers & Prevention 2005;14(2):506-511. |
R832141 (2006) R832141C001 (2005) R827027 (2002) |
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Bocskay KA, Orjuela MA, Tang D, Liu X, Warburton D, Perera FP. Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvement. Environmental and Molecular Mutagenesis 2007;48(2):114-23. |
R832141 (2006) |
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Bradman A, Whyatt RM. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children’s Study: a review of monitoring and measurement methodologies. Environmental Health Perspectives 2005;113(8):1092-1099. |
R832141 (2006) R827027 (2002) R828609 (Final) R831710 (2004) R831710 (2005) |
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Carlton EJ, Moats HL, Feinberg M, Shepard P, Garfinkel R, Whyatt RM, Evans D. Pesticide sales in low-income, minority neighborhoods. Journal of Community Health 2004;29(3):231-244. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Chew GL, Perzanowski MS, Miller RL, Correa JC, Hoepner LA, Jusino CM, Becker MG, Kinney PL. Distribution and determinants of mouse allergen exposure in low-income New York City apartments. Environmental Health Perspectives 2003;111(10):1348-1351. |
R832141 (2005) R832141 (2006) |
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Chew GL, Carlton EJ, Kass D, Hernandez M, Clarke B, Tiven J, Garfinkel R, Nagle S, Evans D. Determinants of cockroach and mouse exposure and associations with asthma in families and elderly individuals living in New York City public housing. Annals of Allergy, Asthma & Immunology 2006;97(4):502-513. |
R832141C004 (2006) |
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Choi H, Jedrychowski W, Spengler J, Camann DE, Whyatt RM, Rauh V, Tsai WY, Perera FP. International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth. Environmental Health Perspectives 2006;114(11):1744-1750. |
R832141 (2006) |
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Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. |
R832141 (2006) R829388 (2006) R829389 (2005) R829390 (2005) R829390C002 (2005) R831710 (2005) |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned from the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R832141 (2006) R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R831710 (2004) R831710 (2005) R831861 (2005) R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R832141 (2005) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829390 (2005) R831709 (2005) R831709C001 (2004) R831710 (2005) R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Mini-Monograph: Methodologic and logistic issues in conducting longitudinal birth cohort studies: Lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10)1414. |
R832141 (2006) |
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Evans DT, Fullilove MT, Green L, Levison M. Awareness of environmental risks and protective actions among minority women in Northern Manhattan. Environmental Health Perspectives 2002;110(S2):271-275. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children’s pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. |
R832141 (2006) R827027 (2002) R828609 (Final) R831709 (2005) R831710 (2004) R831710 (2005) R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Fullilove MT. Links between the social and physical environments. Pediatric Clinics of North America, Review 2001;48(5):1253-1266. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R832141 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) |
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Goldstein IF, Perzanowski MS, Lendor C, Garfinkel RS, Hoepner LA, Chew GL, Perera FP, Miller RL. Prevalence of allergy symptoms and total IgE in a New York City cohort and their association with birth order. International Archives of Allergy and Immunology 2005;137:249-57. |
R832141 (2006) R832141C002 (2005) R827027 (2002) |
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Green L, Fullilove M, Evans D, Shepard P. “Hey, Mom, Thanks!”: Use of focus groups in the development of place-specific materials for a community environmental action campaign. Environmental Health Perspectives 2002;110(S2):265-269. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Jedrychowksi W, Galas A, Pac A, Flak E, Camman D, Rauh V, Perera FP. Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life. European Journal of Epidemiology 2005;20(9):775-782. |
R832141 (2005) |
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Jedrychowski W. Environmental respiratory health in Central and Eastern Europe. Central European Journal of Public Health 2000;8(1):33-39. |
R832141 (2005) |
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Jedrychowski W, Whyatt RM, Camann DE, Bawle UV, Peki K, Spengler JD, Dumyahn TS, Penar A, and Perera FP. Effect of prenatal PAH exposure on birth outcomes and neurocognitive development in a cohort of newborns in Poland. Study design and preliminary ambient data. International Journal of Occupational Medicine and Environmental Health 2003;16(1):21-29. |
R832141 (2005) |
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Jedrychowski W, Whyatt RM, Perera FP, Flak E, Pabian W, Kaim I, Mroz E. Dose response relationship between maternal involuntary tobacco smoking and various birth outcomes. Central European Journal of Occupational and Environmental Medicine 2004;10(4):283-294. |
R832141 (2005) |
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Jedrychowski W, Bendkowska I, Flak E, Penar A, Jacek R, Kaim I, Spengler JD, Camann D, Perera FP. Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environmental Health Perspectives 2004;112(14):1398-1402. |
R832141 (2005) |
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Jedrychowski W, Jankowski J, Flak E, Skarupa A, Mroz E, Sochacka-Tatara E, Lisowska Miszczyk I, Szpanowska-Wohn A, Rauh V, Skolicki Z, Kaim I, Perera FP. Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Annals of Epidemiology 2006;16(6):439-447. |
R832141 (2005) |
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Kinney PL, Chillrud SN, Ramstrom S, Ross J, Spengler JD. Exposures to multiple air toxics in New York City. Environmental Health Perspectives 2002;110(Suppl 4):539-546. |
R832141 (2006) R828678C001 (2002) R828678C001 (2003) R828678C001 (2004) R828678C001 (2006) R828678C001 (2007) |
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Kinney PL, Northridge ME, Correa JC, Gronning E, Joseph E, Prakash S, Goldstein I. On the front lines of environmental asthma intervention in NYC. American Journal of Public Health 2002;92(1):24-26. |
R832141 (2005) R827027 (2002) |
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Kinney PL, Northridge M, Gronning E, Joseph E, Frantz S, Prakash S. On the front lines of environmental interventions to reduce asthma. American Journal of Public Health 2002;92:1-3. |
R832141 (2006) |
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Landrigan PJ, Lioy PJ, Thurston G, Berkowitz G, Chen LC, Chillrud SN, Gavett SH, Georgopoulos PG, Geyh AS, Levin S, Perera F, Rappaport SM, Small C, NIEHS World Trade Center Working Group. Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 2004;112(6):731-739. |
R832141 (2005) R827351 (2003) R827351 (Final) R830827 (2004) R830827 (Final) R831711C002 (2004) |
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Lederman SA, Rauh VA, Weiss L, Stein JL, Hoepner LA, Becker M, Perera FP. The effects of the World Trade Center event on birth outcomes among term deliveries at three lower Manhattan hospitals. Environmental Health Perspectives 2004;112(17):1772-1778. |
R832141 (2005) |
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Liu J, Ballaney M, Al-alem U, Quan C, Jin X, Perera F, Chen LC, Miller RL. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicological Sciences 2007;102(1);76-81. |
R832141 (2006) |
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Mense SM, Sengupta A, Lan C, Zhou M, Bentsman G, Volsky DJ, Whyatt RM, Perera FP, Zhang L. The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicological Sciences 2006;93(1):125-135. |
R832141 (2006) |
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Meyer IH, Whyatt RM, Perera FP, Ford JG. Risk for asthma in 1-year-old infants residing in New York City high-risk neighborhoods. Journal of Asthma 2003;40(5):545-550. |
R832141 (2005) R827027 (2002) |
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Meyer IH, Whyatt RM, Perera FP, Ford JG. Risk for asthma in one-year-old infants residing in New York City high-risk neighborhoods. Journal of Asthma 2003;40(5):545-550. |
R832141 (2006) |
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Miller RL, Chew GL, Bell CA, Biedermann SA, Aggarwal M, Kinney PL, Tsai W-Y, Whyatt RM, Perera FP, Ford JG. Prenatal exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohort. American Journal of Respiratory and Critical Care Medicine 2001;164(6):995-1001. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Miller RL, Garfinkel R, Horton M, Camann D, Pereral FP, Whyatt RM, Kinney PL. Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Chest 2004;126(4):1071-1078. |
R832141 (2006) R832141C002 (2004) R827027 (2002) |
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Miller T, Rauh VA, Glied SAM, Hattis D, Rundle A, Andrews H, Perera F. The economic impact of early life environmental tobacco smoke exposure: early intervention for developmental delays. Environmental Health Perspectives 2006 ;114(10):1585-1588. |
R832141 (2006) R832141C005 (2006) |
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Minkler M, Vásquez VB, Shepard P. Promoting environmental health policy through community based participatory research: a case study from Harlem, New York. Journal of Urban Health 2006;83(1):101-110. |
R832141 (2006) R832141C005 (2006) |
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Mooney LA, Madsen AM, Tang D, Orjuela MA, Tsai W-Y, Garduno ER, Perera FP. Antioxidant vitamin supplementation reduces benzo[a]pyrene-DNA adducts and potential cancer risk in female smokers. Cancer Epidemiology Biomarkers & Prevention 2005;14(1):237-242. |
R832141 (2005) R832141 (2006) |
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Narvaez R, Moors K, Ramirez M, Miller RL. Risks in using non-rigorous Spanish translations of asthma questionnaires. Chest 2007;131(4):1271-2. |
R832141 (2006) |
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Needham LL, Ozkaynak H, Whyatt RM, Barr DB, Wang RY, Naeher L, Akland G, Bahadori T, Bradman A, Fortmann R, Liu L-JS, Morandi M, O’Rourke MK, Thomas K, Quackenboss J, Ryan PB, Zartarian V. Exposure assessment in the National Children’s Study: introduction. Environmental Health Perspectives 2005;113(8):1076-1082. |
R832141 (2006) R827355 (Final) R827355C003 (Final) R831710 (2005) |
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Ozkaynak H, Whyatt RM, Needham LL, Akland G, Quackenboss J. Exposure assessment implications for the design and implementation of the National Children’s Study. Environmental Health Perspectives 2005;113(8):1108-1115. |
R832141 (2005) R831710 (2004) R831710 (2005) |
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Perera FP, Whyatt RM, Jedrychowski W, Rauh V, Manchester D, Santella RM, Ottman R. Recent developments in molecular epidemiology: a study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland. American Journal of Epidemiology 1998;147(3):309-314. |
R832141 (2005) R827027 (2002) |
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Perera FP, Jedrychowski W, Rauh V, Whyatt RM. Molecular epidemiologic research on the effects of environmental pollutants on the fetus. Environmental Health Perspectives 1999;107(S3):451-460. |
R832141 (2005) R827027 (2002) |
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Perera FP. Molecular epidemiology: on the path to prevention? Journal of the National Cancer Institute 2000;92(8):602-612. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Perera FP, Weinstein IB. Molecular epidemiology: recent advances and future directions. Carcinogenesis 2000;21(3):517-524. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Perera F, Hemminki K, Jedrychowski W, Whyatt R, Campbell U, Hsu Y, Santella R, Albertini R, O'Neill JP. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiology Biomarkers & Prevention 2002;11(10):1134-1137. |
R832141 (2005) |
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Perera FP, Illman SM, Kinney PL, Whyatt RM, Kelvin EA, Shepard P, Evans D, Fullilove M, Ford JG, Miller RL, Meyer IH, Rauh VA. The challenge of preventing environmentally related disease in young children: community-based research in New York City. Environmental Health Perspectives 2002;110(2):197-204. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Perera FP, Rauh V, Tsai WY, Kinney PL, Camann DE, Barr DB, Garfinkel R, Tu Y-H, Diaz D, Dietrich J, Whyatt RM. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multi-ethnic population. Environmental Health Perspectives 2003;111(2):201-205. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Perera FP, Tang D, Tu YH, Cruz LA, Borjas M, Bernert T, Whyatt RM. Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage. Environmental Health Perspectives 2004;112(10):1133-1136. |
R832141C001 (2005) R827027 (2002) |
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Perera FP, Rauh V, Whyatt RM, Tsai W-Y, Bernert JT, Tu Y-H, Andrews H, Ramirez J, Qu L, Tang D. Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic population. Environmental Health Perspectives 2004;112(5):626-630. |
R832141 (2005) R832141 (2006) |
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Perera FP, Rauh V, Whyatt RM, Tang D, Tsai WY, Bernert JT, Tu YH, Andrews H, Barr DB, Camann DE, Diaz D, Dietrich J, Reyes A, Kinney PL. A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures. Neurotoxicology 2005;26:573-587. |
R832141 (2006) R827027 (2002) |
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Perera FP, Viswanathan S, Whyatt R, Tang D, Miller RL, Rauh V. Children’s Environmental Health Research — Highlights from the Columbia Center for Children’s Environmental Health. Annual New York Academy of Sciences 2006;1076:15-28. |
R832141 (2006) |
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Perera FP, Rauh V, Whyatt RM, Tsai WY, Tang D, Diaz D, Hoepner L, Barr D, Tu YH, Camann D, Kinney P. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environmental Health Perspectives 2006;114(8):1287-1292. |
R832141 (2006) R827027 (2002) |
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Perera F, Tang DL, Whyatt R, Lederman SA, Jedrychowski W. DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center area, Poland, and China. Cancer Epidemiology Biomarkers & Prevention 2005;14(3):709-714. |
R832141 (2006) R832141C001 (2005) R827027 (2002) |
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Perera, FP and Herbstman, JB. Emerging technology in molecular epidemiology: what epidemiologists need to know. Epidemiology 2008;19(2):350-352. |
R832141 (2006) |
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Perzanowski MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares B, Garfinkel R, Perera F, Goldstein I, Chew G. Endotoxin in inner-city homes: associations with wheeze and eczema in early childhood. Journal of Allergy and Clinical Immunology 2006;117(5):1082-1089. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Perzanowski MS, Chew GL, Divjan A, Johnson A, Goldstein IF, Garfinkel RS, Hoepner LA, Platts-Mills TAE, Perera FP, Miller RL. Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort. Journal of Allergy and Clinical Immunology 2008;121(4):1047-1052. |
R832141 (2006) |
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Rastogi D, Wang C, Mao X, Lendor C, Rothman PB, Miller RL. Antigen-specific immune responses to influenza vaccine in utero. Journal of Clinical Investigation 2007;117(6):1637-1646. |
R832141 (2006) |
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Rauh VA, Andrews HF, Garfinkel RS. The contribution of maternal age to racial disparities in birthweight: a multi-level perspective. American Journal of Public Health 2001;91(11):1815-1824. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Rauh VA, Chew GL, Garfinkel RS. Deteriorated housing contributes to high cockroach allergen level in inner-city households. Environmental Health Perspectives 2002;110(S2):323-327. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Rauh VA, Lamb Parker F, Andrews H, Garfinkel R. Community-level effects on school performance of inner-city Head Start children. Journal of Community Psychology 2003;31(3):1-24. |
R832141 (2005) R832141 (2006) |
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Rauh VA, Whyatt RM, Garfinkel R, Andrews H, Hoepner L, Reyes A, Diaz D, Camaan D, Perera FP. Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children. Neurotoxicology and Teratology 2004;26(3):373-385. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Rauh VA, Garfinkel R, Perera FP, Andrews H, Barr D, Whitehead D, Tang D, Whyatt RM. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first three years of life among inner-city children. Pediatrics 2006;118(6):e1845-e1859. |
R832141 (2006) |
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Sax SN, Bennett DH, Chillrud SN, Kinney PL, Spengler JD. Differences in source emission rates of volatile organic compounds in inner-city residences of New York City and Los Angeles. Journal of Exposure Analysis and Environmental Epidemiology 2004;14(Suppl 1):S95-S109. |
R832141 (2006) R828678C001 (2004) R828678C001 (2006) R828678C001 (2007) |
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Strunk RC, Ford JG, Taggart VT. Reducing disparities in asthma care: priorities for research–National Heart, Lung, and Blood Institute workshop report. Journal of Allergy and Clinical Immunology 2002;109(2):229-237. |
R832141 (2005) R832141 (2006) |
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Tang D, Li T-y, Liu JJ, Chen Y-h, Qu L, Perera F. PAH-DNA adducts in cord blood and fetal and child development in a Chinese cohort. Environmental Health Perspectives 2006;114(8):1297-1300. |
R832141 (2006) |
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Tonne CC, Whyatt RM, Camann DE, Perera FP, Kinney PL. Predictors of personal polycyclic aromatic hydrocarbon exposures among pregnant minority women in New York City. Environmental Health Perspectives 2004;112(6):754-759. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Veglia F, Loft S, Matullo G, Peluso M, Munnia A, Perera F, Phillips DH, Tang D, Autrup H, Raaschou-Nielsen O, Tjonneland A, Vineis P. DNA adducts and cancer risk in prospective studies: a pooled analysis and meta-analysis. Carcinogenesis 2008;29(5):932-936. |
R832141 (2006) |
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Vineis P, Perera F. Molecular epidemiology and biomarkers in etiologic cancer research: the new in light of the old. Cancer Epidemiology Biomarkers and Prevention 2007;16(10):1954-1965. |
R832141 (2006) |
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Wallace D, Wallace R, Rauh V. Community stress, demoralization and body mass index: evidence for social signal transduction. Social Science and Medicine 2003;56(12):2467-2478. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Wallace R. Adaptation, punctuation and information: A rate-distortion approach to non-cognitive ‘learning plateaus’ in evolutionary process. Acta Biotheor 2002;50:101-116. |
R832141 (2006) |
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Wallace R, Wallace RG. Immune cognition and vaccine strategy: Beyond genomics. Microbes Infect 2002;4:521-527. |
R832141 (2006) |
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Wallace R, Wallace RG. Adaptive chronic infection, structured stress, and medical magic bullets: do reductionist cures select for holistic diseases? Biosystems 2004;77:93-108. |
R832141 (2006) R827027 (2002) |
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Wallace R. Comorbidity in psychiatric and chronic physical disease: autocognitive developmental disorders of structured psychosocial stress. Acta Biotheoretica 2004;52(2):71-93. |
R832141 (2006) |
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Whyatt RM, Perera FP, Jedrychowski W, Santella RM, Garte SJ, Bell DA. Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and Glutathione S-Transferase P1 and CYP1A1 polymorphisms. Cancer Epidemiology Biomarkers & Prevention 2000;9(2):207-212. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Whyatt RM, Jedrychowski W, Hemminki K, Santella RM, Tsai WY, Yong K, Perera FP. Biomarkers of polycyclic aromatic hydrocarbon-DNA damage and cigarette smoke exposures in paired maternal and newborn blood samples as a measure of differential susceptibility. Cancer Epidemiology Biomarkers and Prevention 2001;10(6):581-588. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Whyatt RM, Barr DB. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environmental Health Perspectives 2001;109(4):417-420. |
R832141 (2005) R832141 (2006) R827027 (2002) |
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Whyatt RM, Camann DE, Kinney PL, Reyes A, Ramirez J, Dietrich J, Diaz D, Holmes D, Perera FP. Residential pesticide use during pregnancy among a cohort of urban minority women. Environmental Health Perspectives 2002;110(5):507-515. |
R832141 (2005) R832141 (2006) |
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Whyatt RM, Barr DB, Camann DE, Kinney PL, Barr JR, Andrews HF, Hoepner LA, Garfinkel R, Hazi Y, Reyes A, Ramirez J, Cosme Y, Perera FP. Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environmental Health Perspectives 2003;111(5):749-756. |
R832141 (2005) R832141 (2006) R827027 (2002) R828609 (2002) R828609 (2004) R828609 (Final) |
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Whyatt RM, Camann D, Perera FP, Rauh VA, Tang D, Kinney PL, Garfinkel R, Andrews H, Hoepner L, Barr DB. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicology and Applied Pharmacology 2005;206(2):246-254. |
R832141 (2005) R832141 (2006) R827027 (2002) R828609 (2004) R828609 (Final) |
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Whyatt RM, Garfinkel R, Hoepner, LA, Holmes D, Borjas M, Williams MK, Reyes A, Rauh V, Perera F, Camann DE. Within-and between-home variability in indoor-air insecticide levels during pregnancy among an inner-city cohort from New York City. Environmental Health Perspectives 2007;115(3):383-389. |
R832141 (2006) |
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Whyattt RM, Rauh V, Barr DB, Camann DE, Andrews HF, Garfinkel R, Hoepner LA, Diaz D, Dietrich J, Reyes A, Tang D, Kinney PL, Perera FP. Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environmental Health Perspectives 2004;112(10):1125-1132. |
R832141 (2005) R832141 (2006) R828609 (2004) R828609 (Final) |
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Williams MK, Barr DB, Camann DE, Cruz LA, Carlton EJ, Borjas M, Reyes A, Evans D, Kinney PL, Whitehead Jr RD, Perera FP, Matsoanne S, Whyatt RM. An intervention to reduce residential insecticide exposure during pregnancy among an inner-city cohort. Environmental Health Perspectives 2006;114(11):1684-1689. |
R832141 (2006) |
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Özkaynak H, Whyatt R, Needham LL, Akland G, Quackenboss J. Mini-Monograph: Exposure assessment implications for the design and implementation of the National Children's Study. Environmental Health Perspectives 2005;116(10). |
R832141 (2006) |
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Perera FP, Tang D, Rauh VA, Lester K, Tsai WY, Tu YH, Weiss L, Hoepner L, King J, Del Priore G, Lederman SA. Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growth. Environmental Health Perspectives 2005;113(8):1062-1067. |
R832141 (2005) R827027 (2002) |
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HUMAN HEALTH, ENVIRONMENTAL MANAGEMENT, INTERNATIONAL COOPERATION, Scientific Discipline, Health, RFA, Health Effects, Risk Assessment, Health Risk Assessment, Epidemiology, Children's Health, Biochemistry, Environmental Policy, Genetics, exposure assessment, genetic risk factors, children's environmental health, diesel exhaust, assessment of exposure, prenatal exposure, African American, genetic susceptibility, maternal exposure, nutritional risk factors, genetic mechanisms, environmental risks, latino, asthma
Progress and Final Reports:
2004 Progress Report
2005 Progress Report
2006 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832141C001 Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
R832141C002 Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
R832141C003 Mechanistic Research Project
R832141C004 Community-Based Intervention Project: Reduction of Exposure and Risk from Pesticides and Allergens
R832141C005 Community Translation and Application Core (COTAC)
R832141C006 Exposure Assessment Facility Core
R832141C007 Data Management, Statistics and Community Impact Modeling Core
R832141C008 Administrative Core