Jump to main content.

Research Project Search
 Enter Search Term:
   
 NCER Advanced Search

Project 1 -- Pulmonary Metabolic Response

EPA Grant Number: R832414C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R832414
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: San Joaquin Valley Aerosol Health Effects Research Center (SAHERC)
Center Director: Wexler, Anthony S.
Title: Project 1 -- Pulmonary Metabolic Response
Investigators: Fanucchi, Michelle V. , Buckpitt, Alan , Plopper, Charles
Current Investigators: Winkle, Laura Van , Buckpitt, Alan , Fanucchi, Michelle V.
Institution: University of California - Davis
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: October 1, 2005 through September 30, 2010
RFA: Particulate Matter Research Centers (2004)
Research Category: Particulate Matter

Description:

Objective:

Experimental studies performed in our laboratories have demonstrated that neonatal animals are more susceptible to pulmonary injury by bioactivated pollutants, such as the polyaromatic hydrocarbon (PAH) naphthalene and the nitro-PAH 1-nitronaphthalene, than adult animals. This project will determine whether the increased neonatal vulnerability to bioactivated toxicants that has been documented in rodents is exacerbated when the PAH is adsorbed to particulate matter.

Rationale:

We will apply transdisciplinary approaches to test these hypotheses, including histological, biochemical, and microarray analyses. Using defined synthetic particles consisting of graphitic carbon, a PAH, and a transitional metal, we will compare responses in intact airways at different sites of susceptibility (branch points and airway wall) in postnatal and adult rats to responses in human airway epithelial cell lines. As the Architecture Development Project defines the sites of deposition, we will adjust the sites that we are evaluating in the lung accordingly.

Expected Results:

Humans are exposed to multiple compounds early in life, yet most toxicological studies focus on the effects in adults. In addition, decisions regarding acceptable levels of environmental contaminants are based on adult data, which may not translate to children, the most susceptible portion of the population. Our work has already demonstrated that exposure to bioactivated pollutants produces much higher pulmonary toxicity in neonates than in adults. These studies will further define the role of particles in neonatal pulmonary susceptibility to environmental pollutants. Understanding the changes in lung cells following particle exposure at the gene and protein expression level will provide a basis for the development of biomarkers for assessing exposure and toxicity in young children.

Publications and Presentations:

Publications have been submitted on this subproject: View all 6 publications for this subproject | View all 19 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 2 journal articles for this subproject | View all 10 journal articles for this center

Supplemental Keywords:

ambient air, health effects, vulnerability, susceptibility, sensitive population, ozone, exposure, human health, metabolism, sensitive populations, infants, children, metals, oxidants, agriculture, transportation, , Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Risk Assessments, Health Risk Assessment, Physical Processes, Epidemiology, particulate matter, Environmental Chemistry, ultrafine particulate matter, human health risk, lung injury, particle exposure, pariculate matter, air toxics, toxicology, ambient particle health effects, endothelial function, transport and fate, airway disease, epidemiological studies, lung disease, exposure, long term exposure, airborne particulate matter, ambient aerosol, human exposure

Progress and Final Reports:
2006 Progress Report
2007 Progress Report
2008 Progress Report


Main Center Abstract and Reports:
R832414    San Joaquin Valley Aerosol Health Effects Research Center (SAHERC)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832414C001 Project 1 -- Pulmonary Metabolic Response
R832414C002 Endothelial Cell Responses to PM—In Vitro and In Vivo
R832414C003 Project 3 -- Inhalation Exposure Assessment of San Joaquin Valley Aerosol
R832414C004 Project 4 -- Transport and Fate Particles
R832414C005 Project 5 -- Architecture Development and Particle Deposition

Top of page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

Local Navigation

Jump to main content.