| Author, Year
(Reference) |
Study Design |
Sample
Characteristics |
Intervention and/or
Comparison |
Main Results |
Additional
Information | Summary |
| Smaill and
Vazquez,
2007 (3) |
Systematic
review of
randomized,
controlled
trials | 14 trials of antibiotic
treatment involving
2302 pregnant
women, published
between 1960 and
1987
Most trials rated poor
quality because of
unclear or
inadequate
allocation
concealment | Treatment for
asymptomatic
bacteriuria
identified during
pregnancy
(multiple different
antibiotics and
durations) vs. no
treatment | Intervention groups had
a reduced incidence
of pyelonephritis (RR,
0.23 [95% CI,
0.13–0.41]) and
low-birthweight
babies (RR, 0.66 [CI,
0.49–0.89])
Results from 3 trials
that measured the
outcome of preterm
delivery showed no
statistically significant
effect of the
intervention (RR, 0.37
[CI, 0.10–1.36]) | A prior Cochrane
review (4) had
found a
reduction in the
incidence of
preterm delivery
when birthweight
of
<2500 g was
assumed to be
preterm birth | Treating asymptomatic
bacteriuria in
pregnancy reduced
the incidence of
pyelonephritis and
low-birthweight
babies |
| Harding
et al.,
2002 (5) |
Randomized,
double-blind,
placebocontrolled
trial | 105 nonpregnant
women age >16 y
with diabetes,
normal renal
function, and
asymptomatic
bacteriuria
confirmed in 2
consecutive urine
cultures | Trimethoprim-
sulfamethoxazole
(or ciprofloxacin if
resistant organism
or patient was
allergic to sulfa
drugs) twice daily
for 14 d vs. no
treatment | After a mean follow-up
of 27 mo, no
statistically significant
differences were seen
between intervention
and placebo groups
in symptomatic UTIs,
pyelonephritis, or
hospitalization for a
UTI | Patients in the
placebo group
averaged 34 d
of antibiotic use
per 1000 d of
follow-up,
compared with
158 d of
antibiotic use in
the treatment
group | Treating asymptomatic
bacteriuria in
nonpregnant
women with
diabetes increased
antibiotic use but
did not improve
outcomes |
| Meiland
et al.,
2006 (6) |
Prospective
cohort | 644 nonpregnant
women age >18 y
with diabetes | 17% of the study
sample had
asymptomatic bacteriuria
based on a
screening urine
culture; outcomes
for these participants
were compared
with those
in participants
without asymptomatic
bacteriuria | After a mean follow-up
of 6.1 y, there was
no association (after
multivariate
adjustment) between
the presence of
asymptomatic
bacteriuria and
creatinine clearance
or the development
of hypertension | The multivariate
analysis
adjusted for
patient age,
length of
follow-up,
duration of
diabetes, and
presence of
microalbuminuria
at study entry | Asymptomatic
bacteriuria was not
associated with
renal function
decline or the
development of
hypertension in
nonpregnant
women with
diabetes |
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