Characteristic |
Factor |
Studies Indicating an Association and Quality |
Strength of Association with Tumor Response |
Strength of Association with Survival |
---|---|---|---|---|
PET |
Evidence of response on Day 8 PET |
Stroobants, et al., 2003 |
1 year PFS: Positive evidence of response on PET at 8
days |
|
PET vs CT (RECIST) |
Differential ability to predict response to imatinib (by month of assessment) |
Antoch, et al., 2004 |
PET CT Combined
PET/CT Side-by-side
PET and CT |
|
Performance of F-FDG PET and CT in staging GISTS |
Gayed, et al., 2004 |
Sensitivity: Positive
predictive value: |
||
Angio-echography with BR-1 contrast vs. CT (RECIST) |
Ability to predict clinical outcome and therapeutic effect of imatinib |
De
Giorgi et al., 2004 |
Documented
tumor response: |
|
Ultrasound with perfusion software and contrast injection vs. CT |
Ability to predict clinical outcome and therapeutic effect of imatinib |
Lassau, et al., 2004 (abstract)65 |
No significant difference between CT and ultrasound's ability to document response |
Abbreviations: PET = FDG positive emission tomography; CT = computed tomography; TTP = time to progression; OS = overall survival; EFS = event free survival; HR = hazard ratio; RECIST = RECIST response criteria—go to Table 2; NS = not significant