| Key Question | Eligibility Criteria | Number of Articles Meeting Eligibility Criteria and Not in Prior Systematic Reviewa |
|---|---|---|
| Efficacy of screening | RCT Mass screening |
0 |
| Epidemiology of obesity | ||
| a. Prevalence | Large U.S. population-based surveys | 1 |
| b. Health risks | Prospective cohort studies with absolute rates of health risk reported over > 10 yrs | 14 |
| Efficacy of treatment for weight reduction or intermediate outcomes |
||
| a. Counseling and behavioral treatment | - RCT (of fair or good quality) - Outcome: weight loss or BMI reduction; glucose tolerance, blood pressure, lipid disorders - Duration: >1 yr - BMI > 25 kg/m2 - 12 month followup |
21 |
| b. Medications | - RCT (of fair or good quality) - Outcome: weight loss or BMI reduction; glucose tolerance, blood pressure, lipid disorders - Duration: > 6 mos - Population: generalizable to typical U.S. primary care population |
10 |
| c. Surgery | - RCT (of fair or good quality) - Outcome: weight loss or BMI reduction; glucose tolerance, blood pressure, lipid disorders - Duration: > 1 year - Cohort - Initial BMI > 25 kg/m2 - Surgical procedure |
2 |
| Harms of screening and treatment | Same studies as efficacy of counseling/behavioral and medication interventions For surgery, same studies as efficacy plus multiple cohorts and 1 non-RCT |
21 counseling 15 medication 2 surgery |
|
Notes: RCT = randomized controlled trial; BMI = body mass index | ||