| Study, Year (Reference) |
Patients Studied | Reference Assay | Prevalence of Positive Results on Anti-HCV ELISA | Sensitivity | Specificity | Positive Predictive Value | Quality Rating |
|---|---|---|---|---|---|---|---|
| Huber et al., 199687 | Patients admitted because of acute liver disease or suspected chronic hepatitis | PCR | 10% (107/1090) |
94% (107/114) |
97% (946/976) |
78% (107/137) |
Good |
| Prince et al., 199789 | Blood donors with elevated alanine aminotransferase levels | PCR | 18% (54/301) |
100% (51/51) |
98.8% (247/250) |
94% (51/54) |
Fair Narrow patient spectrum |
| Busch et al., 200088 | Blood donors with positive screening test who were retested | Second-generation RIBA or PCR | 100% (1091/1091) |
99.2% (1082/1091) |
Not calculable | Not calculable | Fair Performance of reference assays not standardized, narrow patient spectrum |
* ELISA = enzyme-linked immunosorbent assay; HCV = hepatitis C virus; PCR = polymerase chain reaction; RIBA = recombinant immunoblot assay. | |||||||