Aramite Quickview (CASRN 140-57-8)

Status of Data for Aramite

File First On-Line: 06/01/1991; Last Significant Revision: 06/01/1991

Category (section)	Status	Last Revised
Oral RfD Assessment	No data
Inhalation RfC Assessment	No data
Carcinogenicity Assessment	On-line	06/01/1991

Synonyms

140-57-8 Sulfurous acid, 2-(p-t-butylphenoxy)-1-methylethyl-2-chloroethyl ester Sulfurous acid, 2-(p-tert-butylphenoxy)-1-methylethyl 2-chloroethyl ester Sulfurous acid, 2-chloroethyl 2-(4-(1,1-dimethylethyl)phenoxy)-1-methylethyl ester 2-p-tert-Butylphenoxyisopropyl 2-chloroethyl sulfite

Acaracide AI3-16519 Aracide Aramit more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

Top of page

---

Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

Top of page

Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
• Weight-of-Evidence Narrative:
  • Based on no human data and sufficient data from animal bioassays including increased incidence of liver tumors and/or neoplastic nodules in three strains of male and female rats and males of one strain of mice, and extrahepatic biliary system tumors in dogs following chronic oral exposure.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

---

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)	Extrapolation Method
2.5 x10-2 per mg/kg-day	Linearized multistage procedure, extra risk

Drinking Water Unit Risks
7.1x10-7 per ug/L

Risk Level	Concentration
E-4 (1 in 10,000)	1x102 ug/L
E-5 (1 in 100,000)	1x101 ug/L
E-6 (1 in 1,000,000)	1 ug/L

• Dose-Response Data (Carcinogenicity, Oral Exposure)
  • Tumor Type: Neoplastic liver nodules and carcinomas
  • Test Species: Rat/ FDRL, male and female
  • Route: Oral, Diet
  • Reference: Popper et al., 1960; Oser and Oser, 1962

---

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)	Extrapolation Method
7.1 x10-6 per ug/m3	Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level	Concentration
E-4 (1 in 10,000)	1x101 ug/m3
E-5 (1 in 100,000)	1 ug/m3
E-6 (1 in 1,000,000)	1x10-1 ug/m3

• Dose-Response Data (Carcinogenicity, Inhalation Exposure)
  • Tumor Type: Neoplastic liver nodules and carcinomas
  • Test Species: Rat/ FDRL, male and female
  • Route: Oral, Diet
  • Reference: Popper et al., 1960; Oser and Oser, 1962