Coke oven emissions Quickview (CASRN 8007-45-2)

Status of Data for Coke oven emissions

File First On-Line: 05/01/1989; Last Significant Revision: 01/01/1991

Category (section)	Status	Last Revised
Oral RfD Assessment	No data
Inhalation RfC Assessment	No data
Carcinogenicity Assessment	On-line	03/01/1994

Synonyms

8007-45-2 Coke oven emissions

Coal tar pitch volatiles, as benzene soluble organics

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

Top of page

---

Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

Top of page

Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • A (Human carcinogen)
• Weight-of-Evidence Narrative:
  • Studies of coke oven workers have shown increased risk of mortality from cancer of the lung, trachea and bronchus; cancer of the kidney; cancer of the prostate; and cancer at all sites combined. In animals, extracts and condensates of coke oven emissions were found to be carcinogenic in both inhalation studies and skin-painting bioassays. The mutagenicity of whole extracts and condensates, as well as their individual components, provides supportive evidence for carcinogenicity.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

---

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

• Not Assessed under the IRIS Program.

---

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)	Extrapolation Method
6.2 x10-4 per ug/m3	Linearized multistage procedure

Inhalation Concentrations at Specified Risk Levels

Risk Level	Concentration
E-4 (1 in 10,000)	2x10-1 ug/m3
E-5 (1 in 100,000)	2x10-2 ug/m3
E-6 (1 in 1,000,000)	2x10-3 ug/m3

• Dose-Response Data (Carcinogenicity, Inhalation Exposure)
  • Tumor Type: Respiratory cancer
  • Test Species: Human, male
  • Route: Inhalation, Occupational
  • Reference: Mazumdar et al., 1975; Land, 1976