Avermectin B1 Quickview (CASRN 65195-55-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Avermectin B1

File First On-Line: 07/01/1989; Last Significant Revision: 07/01/1989

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	07/01/1989
Inhalation RfC Assessment	No data
Carcinogenicity Assessment	No data

Synonyms

Abamectin
Antibiotic C 076B1A
Avermectin B1
Avermectin B1A

5-o-Demethylavermectin ALA
65195-55-3
Avermectin a1a, 5-o-demethyl-

Avermectin B1 Source Documents

Avermectin B1 Summary

Revision History

Date	Section	Description
04/01/1997	III., IV., V.	Drinking Water Health Advisories, EPA Regulatory Acions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.

See IRIS Summary for complete revision history.

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect	Point of Departure*	UF	MF	RfD
Increased retinal folds in weanlings, decreased viability and lactation indices, decreased pup body weight, increase of dead pups at birth	NOEL : 0.12 mg/kg-day	300	1	4 x10^-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Principal and Supporting Studies (Oral RfD)
- 2-generation rat reproduction study, Merck and Co., 1984
Confidence in the Oral RfD
- Study -- Medium
- Database -- High
- RfD -- High

Top of page

Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

Top of page