Acetophenone Quickview (CASRN 98-86-2)

Status of Data for Acetophenone

File First On-Line: 08/22/1988; Last Significant Revision: 02/01/1991

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	01/01/1989
Inhalation RfC Assessment	No data	08/01/1992
Carcinogenicity Assessment	On-line	02/01/1991

Synonyms

98-86-2 Acetophenone Acetyl benzene

Hypnone Phenyl methyl acetone

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect	Point of Departure*	UF	MF	RfD
General toxicity	NOAEL : 423 mg/kg-day	3000	1	1 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Oral RfD)
  • Rat oral subchronic study, Hagen et al., 1967
• Confidence in the Oral RfD
  • Study -- Low
  • Database -- Low
  • RfD -- Low

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • D (Not classifiable as to human carcinogenicity)
• Weight-of-Evidence Narrative:
  • Based on no human data and no animal data.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

• Not Assessed under the IRIS Program.

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.