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Summaries of Independent Scientist (K) Awards

Wyrwich, Kathleen

Institution: Saint Louis University
Grant Title: Population and Global Transition Assessments of HRQoL
Grant Number: K02 HS011635
Duration: 5 years (2001-2006)
Total Award: $484,700

Project Description: This project has 5 main goals:

  1. To compare the three health-related quality of life (HRQoL) measures in Healthy People 2010.
  2. To establish benchmarks for categorizing score ranges for these measures.
  3. To identify change over time in these measures to evaluate health interventions.
  4. To develop crosswalk score estimation methods between these measures and other widely used measures.
  5. To model underlying cognitive processes that patients employ when they assess their HRQol changes.

Career Goals: Dr. Wyrwich is Assistant Professor of Health Services Research, St. Louis University. Her long-term career goals encompass:

  • Developing new methodologies in the field of HRQoL measurement and interpretation.
  • Assisting other researchers and students with technical and scientific HRQoL matters.
  • Encouraging multidisciplinary collaborations between basic, behavioral, and clinical research centered on improved HRQoL measurement and evaluation.
  • Attaining a tenured university position and national leadership in health services research.

Progress to Date: Dr. Wyrwich continued her academic training, and has published 32 manuscripts and two additional ones are in press. Four other manuscripts are under review. She had 47 presentations at professional meetings and conferences.

Future Plans: Dr. Wyrwich will attend professional meetings and publish all planned manuscripts. Further, she will develop and submit an R01 application.

Highlights and Specific Accomplishments:

  • Professional Societies:
    • Association for Health Services Research and Health Policy.
    • American Public Health Association.
    • International Society for Quality of Life Research.
  • Awards:
    • Linda Hunter Memorial Quality of Life Annual Presenter, Society of Gynecologic Nurse Oncologists.

K-Generated Publications:

  • Wu H-S, Wyrwich KW. Assessing fatigue in persons with cancer: further Validation of Wu CancerFatigue Scale. Journal of Pain and Symptom Management 2006 (in press).
  • Wyrwich KW, Tardino VM. Understanding global transition assessments. Quality of Life Research 2006 (in press).
  • Wyrwich KW, Metz SM, Kroenke K, et al. Interpreting quality of life data: methods for community consensus in asthma. Annals of Allergy, Asthma & Immunology 2006 (in press).
  • Haughton LT, Wyrwich KW, Brownson RC, et al. Individual, social, environmental, and physical environmental influences on physical activity among black and white adults: A structural equation approach. Annals of Behavioral Medicine 2006;31(1):36-44.
  • Boehmer TK, Hoehner CM, Wyrwich KW, et al. Correspondence between perceived and observed measures of neighborhood environmental supports for physical activity. Journal of Physical Activity and Health 2006;3(1):22-36.
  • Leidy NK, Wyrwich KW. Bridging the gap: using triangulation methodology to estimate minimal clinically important differences (MCIDs). Journal of Chronic Obstructive Pulmonary Disease 2005;2:157-65.
  • Leira EC, Cruz-Flores S, Wyrwich KW, et al. Improving pilot response to in-flight strokes: a randomized controlled trial. Cerebrovascular Disease 2005;19:317-22.
  • Wyrwich KW, Tierney WM, Babu AN, et al. A comparison of clinically important differences in health-related quality of life for patients with chronic lung disease, asthma, or heart disease. Health Services Research 2005;40(2):577-92.
  • Wyrwich KW, Bullinger M, Aaronson N, et al., and The Clinical Significance Consensus Meeting Group. Estimating clinically significant differences in quality of life outcomes. Quality of Life Research 2005;14(2):285-95.
  • Norman GR, Sloan JA, Wyrwich KW. The truly remarkable universality of half a standard deviation: confirmation through another look. Expert Review of Pharmacoeconomics & Outcomes Research 2004;4(5):581-85.
  • Wolinsky FD, Wyrwich KW, Metz SM, et at. Test-retest reliability of the Mirowsky Ross 2x2 Index of the Sense of Control. Psychological Reports 2004;94(2):725-32.
  • Wyrwich KW, Tardino VS. A blueprint for symptom scales and responses: measurement and reporting. Gut 2004;53:45-48.
  • Wyrwich KW, Minimal important difference thresholds and the standard error of measurement: Is there a connection? Journal of Biopharmaceutical Statistic 2004;14(1):97-110.
  • Wyrwich KW, Spertus JA, Tierney WM, et al. Clinically Important Differences in Health Status for Patients with Heart Disease: An Expert Consensus Panel Report. American Heart Journal 2004;147:615-22.
  • Leira EC, Bertrand ME, Wyrwich KW, et al. Continuous or emergent EEG: can bedside caregivers recognize epileptiform discharges? Intensive Care Medicine 2004;30:207-12.
  • Wyrwich KW, Nelson HS, Tierney WM, et al. Clinically important differences in health-related quality of life for patients with asthma: an expert consensus panel report. Annals of Asthma, Allergy, and Immunology 2003;91(2):148-53.
  • Wolinsky FD, Wyrwich KW, Babu AN, et al. Age, aging, and the sense of control among older adults: a longitudinal reconsideration. Journal of Gerontology: Social Sciences 2003;58B(4):S212-20.
  • Wolinsky FD, Wyrwich KW, Babu AN, et al. 9-11, personal stress, mental health, and the sense of control among older adults. Journal of Gerontology: Social Sciences 2003;58B(3):S146-50.
  • Norman GR, Sloan JA, Wyrwich KW. Interpretation of Changes in Health-related Quality of Life: The remarkable universality of half a standard deviation. Medical Care 2003;41(5):582-92.
  • Norman GR, Sloan JA, Wyrwich KW. Is it simple or simplistic? Medical Care 2003;41(5):599-601.
  • Andresen EM, Catlin TK, Wyrwich KW, Jackson-Thompson J. Retest reliability of surveillance questions on health-related quality of life. Journal of Epidemiology and Community Health 2003;57(5):339-43.
  • Garza A.G. and Wyrwich KW. Health utility measures and the standard gamble. Academic Emergency Medicine 2003;10:360-3.
  • Wyrwich KW, Fihn SD, Tierney WM, et al. Clinically important changes in health-related quality of life for patients with chronic obstructive pulmonary disease: an expert consensus panel report. Journal of General Internal Medicine 2003;18(3):196-202.
  • Wyrwich KW. Statistical interpretation of HRQoL changes in COPD: development of the MCID standards and related approaches. European Respiratory Review 2002;12(83):94-103.
  • Wyrwich KW. Assessing the clinical significance for health-related quality of life measures in oncology. Journal of Gynecologic Oncology Nursing 2002;12(1):7-8.
  • Guyatt GH, Osoba D, Wu AW, Wyrwich KW, Norman GR, and the Clinical Significance Consensus Meeting Group. Methods to explain the clinical significance of health status measures. Mayo Clinic Proceedings 2002;77(4):371-83.
  • Sloan J, Cella D, Wyrwich KW, et al., and the Clinical Significance Consensus Writing Team. Assessing Clinical Significance in Measuring Oncology Patient Quality of Life: Introduction to the series of papers, content overview, and definition of terms. Mayo Clinic Proceedings 2002;77(4):367-70.
  • Cella D, Bullinger M, Wyrwich KW, et al., and the Clinical Significance Consensus Meeting Group. Group versus individual approaches to understanding the clinical significance of differences or changes in quality of life. Mayo Clinic Proceeding 2002;77(4):384-95.
  • Sloan J, Aaronson N, Wyrwich KW, et al., and the Clinical Significance Consensus Meeting Group. Assessing the clinical significance of single items relative to summated scores. Mayo Clinic Proceedings 2002;77(5):479-87.
  • Frost M, Bonomi A, Wyrwich KW, et al., and the Clinical Significance Consensus Meeting Group. Patient, clinician and population perspectives on determining the clinical significance of quality of life scores. Mayo Clinic Proceedings 2002;77(5):488-94.
  • Sprangers M, Moinpour C, Wyrwich KW, et al., and the Clinical Significance Consensus Meeting Group. Assessing meaningful change over time in quality of life: a users' guide for clinicians. Mayo Clinic Proceedings 2002;77(6):561-71.
  • Symonds T, Berzon R, Wyrwich KW, et al., and the Clinical Significance Consensus Meeting Group. The clinical significance of QOL results: practical considerations for specific audiences. Mayo Clinic Proceedings 2002;77(6):572-83.
  • Wyrwich KW, Tierney WM, Wolinsky FD. Using the standard error of measurement to identify important changes on the Asthma Quality of Life Questionnaire. Quality of Life Research 2002;11(1):1-7.
  • Wolinsky FD, Krygiel JS, Wyrwich KW. Hospitalization for prostate cancer among the older men in the Longitudinal Study on Aging, 1984-1991. Journal of Gerontology: Medical Sciences 2002;57(2):M115-21.

AHRQ Research Portfolio: Safety and Quality; Data Development; Training.
AHRQ Goals: Safety and Quality

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