Prepared for:

Agency for Healthcare Research and Quality

U.S. Department of Health and Human Services

540 Gaither Road

Rockville, MD 20850

www.ahrq.gov

Contract No. 290-02-0018

Prepared by:

The Johns Hopkins University Evidence-based Practice Center, Baltimore, MD

Investigators

Jodi B. Segal, M.D., M.P.H.

John J. Strouse, M.D.

Mary Catherine Beach, M.D., M.P.H.

Carlton Haywood, M.A.

Catherine Witkop, M.D., M.P.H.

Haeseong Park, M.D., M.P.H.

Renee F. Wilson, M.Sc.

Eric B. Bass, M.D., M.P.H.

Sophie Lanzkron, M.D.

AHRQ Publication No. 08-E007

February 2008

This document is in the public domain and may be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders.

Suggested Citation:

Segal JB, Strouse JJ, Beach MC, Haywood C, Witkop C, Park HS, Wilson RF, Bass EB, Lanzkron S. Hydroxyurea for the Treatment of Sickle Cell Disease. Evidence Report/Technology Assessment No. 165. (Prepared by Johns Hopkins University Evidence-based Practice Center under contract No. 290-02-0018). AHRQ Publication No. 08-E007. Rockville, MD. Agency for Healthcare Research and Quality. February 2008.

This report is based on research conducted by the Johns Hopkins University Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0018). The findings and conclusions in this document are those of the author(s), who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment.

This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

No investigators have any affiliations or financial involvement (e.g., employment, consultancies, honoraria, stock options, expert testimony, grants or patents received or pending, or royalties) that conflict with material presented in this report.