Prepared for:

Agency for Healthcare Research and Quality

U.S. Department of Health and Human Services

540 Gaither Road

Rockville, MD 20850

http://www.ahrq.gov

Contract No. 290-97-0001

Prepared by:

Southern California Evidence-based Practice Center

Paul Shekelle, MD, PhD

EPC Director

Ian Coulter, PhD

Mary Hardy

Principal Investigators

Sally C. Morton, PhD

EPC Co-Director/Senior Statistician

Jay Udani, MD

Myles Spar, MPH, MD

Karen Oda, MD

Lara K. Jungvig, BA

Wenli Tu, MS

Roberta Shanman, MLS

Sydne Newberry, PhD

Louis R. Ramirez, BA

Di Valentine, JD

Investigators

AHRQ Publication No. 03-E047

August 2003

ISBN: 1-58736-091-5

ISSN: 1530-4396

This report may be used, in whole or in part, as the basis for development of clinical practice guidelines and other quality enhancement tools, or a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

AHRQ is the lead Federal agency charged with supporting research designed to improve the quality of health care, reduce its cost, address patient safety and medical errors, and broaden access to essential services. AHRQ sponsors and conducts research that provides evidence-based information on health care outcomes; quality; and cost, use, and access. The information helps health care decisionmakerspatients and clinicians, health system leaders, and policymakersmake more informed decisions and improve the quality of health care services.

Suggested Citation: Coulter I, Hardy M, Shekelle P, et al. Effect of the Supplemental Use of Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cancer. Evidence Report/Technology Assessment Number 75. (Prepared by Southern California Evidence-based Practice Center under Contract No. 290-97-0001.) AHRQ Publication No. 03-E047. Rockville, MD: Agency for Healthcare Research and Quality. August 2003.