Summaries of Independent Scientist (K) Awards

Siderowf, Andrew

Institution: Trustees of the University of Pennsylvania
Grant Title: Health Preference Assessment in Parkinson's Disease
Grant Number: K08 HS00004
Duration: 5 years (2000-2005)
Total Award: $644,700

Project Description: The project has three main goals:

1. To produce a series of vignettes describing Parkinson's Disease (PD)-related health states, and to elicit societal preference weights for these vignettes.
2. To conduct a cross sectional study comparing this set of preferences to values derived from pre-scored multi-attribute health classification systems, and to preferences elicited from patients and caregivers.
3. To conduct a longitudinal study to measure reliability and responsiveness of preference-based measures in PD patients and their caregivers.

Career Goals: Dr. Siderowf is a fellowship-trained neurologist in the evaluation of health services research for patients with Parkinson's Disease and other neuro-degenerative diseases and seeks to become an independent health services researcher in these areas.

Progress to Date: Dr. Siderowf has completed his K-funded research.

Highlights and Specific Accomplishments:

• Assistant Professor of Neurology, University of Pennsylvania School of Medicine.
• Panels and Committees by Invitation:
  • 2002 Data Safety Monitoring Committee, "Transcription and Therapy for Huntington's Disease (Steven M. Hersch, M.D., Ph.D., Principal Investigator, National Institute of Neurological Disorders and Stroke (NINDS) Program Project Grant  NS45242).
  • 2003 Symposium Committee; Parkinson Study Group.
• Professional Societies:
  • American Academy of Neurology.
  • Movement Disorders Society.
• Invitational Lectures:
  • February 12, 2004, "Treatment of Hyperkinetic Movement Disorders" Penn Neurology 2004 continuing medical education (CME) Course, San Juan PR.
  • March 12, 2004, "Follow-up Management after DBS" Philadelphia DBS Programming Seminar, Philadelphia.
  • April 2, 2005, "Practical Management of Parkinson's Disease" St. Joseph's Medical Center, Towon, MD.
  • April 12, 2005, "Update on Parkinson's Disease" Syracuse Community General Hospital, Syracuse, NY.

K-Generated Publications:

• Siderowf A, Fahn S. The Role and Design of Clinical Trials in Parkinson's Disease. In Pfeiffer R, Ebadi M. eds: Parkinson's Disease. CRC Press Boca Raton, FL, pp. 961-74.
• Holloway R, Siderowf A. Evidence-based Neurotherapeutics: A Spectrum of Evidence. NeuroRx 2004;1:295-97.
• Siderowf A. Evidence from clinical trials: Can we do better? NeuroRx 2004;1:363-71.
• Lynch DR, Mozley PD, Siderowf AD, et al. Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's Disease. Movement Disorders 2003;18:804-11.
• Siderowf A, Stern MB. Update on Parkinson's Disease. Annals of Internal Medicine. 2003;138:651-8.
• Elman L, Siderowf A. McCLuskey L. Nocturnal Oximetry: Utility in respiratory management of ALS. Journal of Physical Medicine and Rehabilitation 82 (11):866-70. 2003.
• Cheng EM, Siderowf Am Swarztrauber K, et al. Development of Quality of Care Inbdicators for Parkinson's Disease. Movement Disorders 2004;19(2):136-50.
• Siderowf A, Fahn. The Role and Design of Clinical Trials in Parkinson's Disease. In Pfeiffer R, Ebadi, M. eds: Parkinson's Disease (in press).
• Holloway R, Siderowf A. Evidence-based Neurotherapeutics: A Spectrum of Evidence. NeuroRx (in press).
• Siderowf A. Evidence from clinical trails: Can we do better? NeuroRx (in press).

AHRQ Research Portfolios: Care Management; Training.
AHRQ Goals: Effectiveness

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