Summaries of Independent Scientist (K) Awards

Jenkins, Pamela

Institution: Dartmouth College
Grant Title: Improving Outcomes in Hypoplastic Left Heart Syndrom
Grant Number: K02 HS00010
Duration: 5 years (2000-2005)
Total Award: $657,200

Project Description: This research had three main aims:

1. To identify pre-operative and operative characteristics predictive of mortality in children with hypoplastic left heart syndrome (HLHS).
2. To conduct functional testing of these pediatric patients.
3. To conduct yearly survey of families with HLHS children.

Career Goals: Dr. Jenkins seeks to improve the health outcomes of infants and children with congenital heart disease. Her K research will create a solid basis for decisionmaking in individual patients with HLHS, allow for case-mix adjustment for centers to evaluate their outcomes, and initiate the collaboration between pediatric cardiac care teams necessary to improve outcomes for infants with HLHS.

Progress to Date: Dr. Jenkins is nearing the end of her grant and thus has completed all of her data collection and analysis.

Highlights and Specific Accomplishments:

• Development of health perceptions assessment tool for children.
• Professional societies: American Academy of Pediatrics.
• Professional meetings:
  • Society for Pediatric Research Conference; Seattle.
  • American Heart Association national meeting, Orlando.
  • Cardiology 2004 meeting, Orlando.
  • Society for Thoracic Surgery 2005 meeting, Tampa.
  • American Academy of Thoracic Surgery meeting, 2005, San Francisco.

K-Generated Publications:

• Jenkins PC, et al. Morbidities in patients with hypoplastic left heart syndrome. Pediatric Cardiology 2004;25:3-10.
• Jenkins PC, et al. Morbidities and health services in patients with hypoplastic left heart syndrome. Pediatric Research 2003;53(Suppl):2017.
• Jenkins PC. Sindrome del corazon izquierdo hipoplasico: supervivencia, riesgo de mortalidad y tendencias en el tratamiento [hypoplastic left heart syndrome: survival, mortality risk, and trends in management]. Journal Salud (i) Cienci.
• Jenkins PC, Flanagan MF, Sargent JD, et al. A comparison of treatment strategies for hypoplastic left heart syndrome using decision analysis. Journal of the American College of Cardiology 2001;38:1181-7.
• Jenkins PC, Flanagan MF, Jenkins KJ, et al. Survival analysis and risk factors for mortality in transplantation and staged surgery for hypoplastic left heart syndrome. Journal of the American College of Cardiology 2000;36:1178-85.
• Jenkins PC, Rosenberg MC, Gonzalez PK. Health perceptions of children with hypoplastic left heart syndrome. Pediatric Research 2005;758.
• Jenkins PC, Modlin JF. Decision analysis in the event of a polio outbreak. Pediatric Research 2004;55(Part 2):323A.

AHRQ Research Portfolios: Care Management; Training.
AHRQ Goals: Effectiveness

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