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Chemical Sampling Information |
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| Diisobutyl Ketone |
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General Description
Synonyms: DIBK; sym-Diisopropyl acetone; 2,6-Dimethyl-4-heptanone; Isovalerone; Valerone
OSHA IMIS Code Number: 0924
Chemical Abstracts Service (CAS) Registry Number: 108-83-8
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: MJ5775000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1157 128 [27 KB PDF]
NIOSH Pocket Guide to Chemical Hazards, Diisobutyl Ketone: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 50 ppm, 290 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 50 ppm, 290 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 50 ppm, 290 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 25 ppm, 145 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 25 ppm, 150 mg/m3 TWA
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm
Potential symptoms: Eye, nose, throat irritation; headache; cough, sore throat; nausea, vomiting; dizziness; dermatitis; numbness of the skin; liver, kidney damage.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)
Affected organs: Eyes, skin, respiratory system, CNS, liver, kidneys
Notes:
- Above 49°C, diisobutyl ketone vapor/air mixtures may be explosive.
- Deficits in manual motor speed, verbal fluency, visuospacial organization, and short-term memory, as well as white matter lesions in subcortical brain regions detected by MRI examination, were reported for a senior laboratory technician occupationally exposed to unknown concentrations of vapors of diisobutyl ketone, which was heated under pressure.
- The concentration of diisobutyl ketone causing a 50% decrease in the respiratory rate of mice (a measure of sensory irritation) was reported to be 287 ppm.
Date Last Revised: 06/14/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Diisobutyl Ketone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Diisobutyl ketone.
- De Ceaurriz, J., Micillino, J.C., Marignac, B., Bonnet, P., Muller, J. and Guenier, J.P.: Quantitative evaluation of sensory irritating and neurobehavioral properties of aliphatic ketones in mice. Food Chem. Toxicol. 22(7): 545-549, 1984.
- Pohanish, R.P. (editor): Diisobutyl Ketone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 895-896.
- White, R.F., Feldman, R.G., Moss, M.B. and Proctor, S.P.: Magnetic resonance imaging (MRI), neurobehavioral testing, and toxic encephalopathy: two cases. Environ. Res. 61(1): 117-123, 1993.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 1300) [27 KB PDF]
method classification: Fully Validated
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