Chemical Sampling Information
	2,4-Dichlorophenol
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 2,4-DCP; DCP OSHA IMIS Code Number: 0895 Chemical Abstracts Service (CAS) Registry Number: 120-83-2 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: SK8575000 Chemical Description and Physical Properties: needle-like crystals with a characteristic medicinal taste and odor molecular formula: C6H4Cl2O molecular weight: 163.0 boiling point: 210°C flash point: 114°C open cup melting point: 45°C vapor pressure: 133 kPa @ 53°C Potentially hazardous incompatibilities: reacts violently with strong oxidants Health Factors International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, Possibly carcinogenic to humans. [381 KB, PDF] Potential symptoms: Irritation of eyes, nose, throat, skin; cough, sore throat, shortness of breath; eye redness, pain, burns; skin redness, pain, blisters; INGES. ACUTE: Burning sensation, abdominal pain; labored breathing; weakness, tremor, convulsions; shock or collapse; SKIN ABS. Health Effects: Acute toxicity (HE4); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14). Affected organs: Skin, eyes, CNS Notes: OSHA does not have a PEL for 2,4-dichlorophenol (2,4-DCP). EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for 2,4-DCP is 0.003 mg/kg/day. Skin contact with liquid 2,4-DCP should be treated as a life-threatening medical emergency, as several deaths from accidental splashing or spraying at work have been reported, and there is no known antidote. The NOAEL for 2,4-DCP in rats that received it orally in their food for 10 weeks was reported to be 33-49 mg/kg/day. The measurement of urinary 2,4-DCP is not specific for one parent compound, as it can be a metabolite of the organophosphate pesticides, dichlofention and prothiofos, as well as of the organochlorine pesticides, 1,3-dichlorobenzene, bifenox, diclofop, 2,4-dichlorophenoxybutyric acid, dichloroprop, and nitrofen. Date Last Revised: 03/29/2007 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): 2,4-Dichlorophenol. U.S. EPA Integrated Risk Information System: 2,4-Dichlorophenol (CASRN 120-83-2). Aoyama, H., et al.: A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats. J. Toxicol. Sci. 30(Special issue): 59-78, 2005. Center for Disease Control and Prevention: Occupational fatalities associated with 2,4-dichlorophenol (2,4-DCP) exposure, 1980-1998. MMWR Morb. Mortal. Wkly. Rep. 49(23): 516-518, 2000. Mage, D.T., Allen, R.H., Gondy, G., Smith, W., Barr, D.B. and Needham, L.L.: Estimating pesticide dose from urinary pesticide concentration data by creatinine correction in the Third National Health and Nutrition Examination Survey (NHANES-III). J. Expo. Anal. Environ. Epidemiol. 14(6): 457-465, 2004. Pohanish, R.P. (editor): 2,4-Dichlorophenol. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 826-828. Monitoring Methods used by OSHA Bulk method: Limit the amount of bulk submitted to one gram or approx. one mL All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.