 |
Chemical Sampling Information |
|
| Vanadium Fume (as V2O5) |
|
General Description
Synonyms: Vanadium pentoxide fume; Divanadium pentoxide fume; Vanadic anhydride fume; Vanadium oxide fume; Other synonyms vary depending upon the specific vanadium compound.
OSHA IMIS Code Number: 2571
Chemical Abstracts Service (CAS) Registry Number: 1314-62-1
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: YW2460000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2862 151
NIOSH Pocket Guide to Chemical Hazards, Vanadium fume: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 0.1 mg/m3 Ceiling
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 0.1 mg/m3 Ceiling
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 0.1 mg/m3 Ceiling
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.05 mg/m3 TWA - Respirable fraction; see Appendix C paragraph C.; Appendix A4 - Not Classifiable as a Human Carcinogen; BEI (TLV listed under Vanadium pentoxide)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.05 mg V/m3 Ceiling (15 Minutes)
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 35 mg V/m3
Potential symptoms: Irritation of eyes, throat; green tongue, metallic taste, sore throat; cough, fine rales, wheezing, bronchitis, dyspnea (breathing difficulty), pulmonary edema; epistaxis (bloody nose); eczema; conjunctivitis; headache, dry mouth, dizziness, nervousness, insomnia, tremor; INGES ACUTE: Abdominal cramps, nausea, vomiting, diarrhea (with black stools); drowsiness, unconsciousness.
Health Effects: Irritation – Eye, Nose, Throat, Skin---Marked (HE14) Acute and chronic bronchial damage (HE11 and HE10).
Affected organs: Eyes, skin, respiratory system
Notes:
- EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) of vanadium pentoxide is 0.009 mg/kg/day.
- Two-year inhalational studies by the NTP found that vanadium pentoxide was a lung carcinogen in male rats and male and female mice.
- Since vanadium is mainly excreted by the kidneys, with a terminal half-life in serum of about 10 days, urinary vanadium is used as a biomarker of occupational exposure to vanadium pentoxide.
- The ACGIH established a biological threshold concentration in urine collected at the end of the work week of 50 µg of vanadium/gram of creatinine in urine. The concentration in the general population is usually less than 1 µg V/gram creatinine.
Date Last Revised: 02/14/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Vanadium fume.
- International Chemical Safety Cards (WHO/IPCS/ILO): Vanadium pentoxide.
- U.S. EPA Integrated Risk Information System: Vanadium pentoxide (CASRN 1314-62-1).
- Barceloux, D.G.: Vanadium. J. Toxicol. Clin. Toxicol. 37(2): 265-278, 1999.
- Heinemann, G., Fichtl, B. and Vogt, W.: Pharmacokinetics of vanadium in humans after intravenous administration of a vanadium containing albumin solution. Br. J. Clin. Pharmacol. 55(3): 241-245, 2003.
- Irsigler, G.E., Visser, P.J. and Spangenberg, P.A.L.: Asthma and chemical bronchitis in vanadium plant workers. Am. J. Ind. Med. 35(4): 366-374, 1999.
- Pohanish, R.P. (editor): Vanadium Pentoxide. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2310-2312.
- Ress, N.B., et al.: Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice. Toxicol. Sci. 74(2): 287-296, 2003.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
-
sampling media: Mixed Cellulose Ester Filter (MCEF) 0.8 microns
maximum volume: 960 Liters minimum volume: 480 Liters maximum flow rate: 2.0 L/min (TWA)
maximum volume: 30 Liters maximum flow rate: 2.0 L/min (Ceiling)
current analytical method: Inductively Coupled Argon Plasma; ICP/DCP-AES
method reference: OSHA Analytical Method (OSHA ID-125G)
method classification: Fully Validated
note: Analytical method does not distinguish between dust and fume. If confirmation of Vanadium Pentoxide is necessary use the following sampling procedure:
-
sampling media: Tared Low Ash Polyvinyl Chloride (LAPVC) filter 5 microns
maximum volume: 960 Liters minimum volume: 480 Liters maximum flow rate: 2.0 L/min
current analytical method: X-ray Diffraction, XRD; and X-ray Fluorescence, XRF
method reference: OSHA Analytical Method (OSHA ID-185)
method classification: Fully Validated
note: Submit as a separate sample.
* All Trademarks are the property of their respective owners.
|
|
|
|
 |
|
Back to Top
www.osha.gov
