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Chemical Sampling Information |
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| 1,3,5-Triglycidyl Isocyanurate |
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General Description
Synonyms: TGIC; TGT; s-Triazine-2,4,6(1H,3H,5H)-trione; Triglycidyl Isocyanurate; 1,3,5-Triglycidyl-s-triazinetrione; Tris(epoxypropyl)isocyanurate; 1,3,5-tris(2,3-epoxypropyl)-s-Triazine-2,4,6(1H,3H,5H)-trione
OSHA IMIS Code Number: T405
Chemical Abstracts Service (CAS) Registry Number: 2451-62-9
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: XZ1994900
Chemical Description and Physical Properties: white powder or granule
molecular formula: C12H15N3O6
molecular weight: 297.3
melting point: 95°C
Potentially hazardous incompatibilities: Molten triglycidyl isocyanurate reacts rapidly with primary and secondary amines, carboxylic acids and anhydrides, thiols, phenols and alcohols.
Exposure Limits
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.05 mg/m3 TWA (TLV listed under 1,3,5-Triglycidyl-s-triazinetrione)
Health Factors
Potential symptoms: Eye, nose, throat, skin irritation; rhinitis, cough, dyspnea, wheezing, asthma; dermatitis, skin sensitization; in animals: eye redness, chemosis (swelling around eyes), ocular discharge, corneal opacity; in animals: decreased fertility of males.
Health Effects: Allergic contact dermatitis (HE3); Respiratory sensitization---Asthma (HE9); Irritation-Eyes---Marked (HE14); Mutagen (HE2).
Affected organs: Skin, eyes, respiratory system
Notes:
- OSHA does not have a PEL for 1,3,5- triglycidyl isocyanurate (TGIC), which has two stereoisomers, α and ß. It is not known whether the isomers differ in toxicity.
- Studies of TGIC as a potential anticancer drug indicated a very short half-life (< 2 minutes) in plasma after intravenous infusion in patients, possibly due to rapid metabolism by epoxide hydrolase activity.
- TGIC forms adducts with DNA and has tested positive in many mutagenicity/ genotoxicity tests.
- Male mice inhaling TGIC 6 hours/day for 5 consecutive days had a reduction in fertility (from toxicity to sperm-producing cells in testes). The NOAEL for general toxicity was 10 mg/m3, and the NOAEL for decreased fertility was 2.5 mg/m3 in these mice.
- A more recent publication mentioned anecdotal complaints of testicular atrophy in men and menstrual irregularities in women exposed to TGIC during powder paint coating work. However, no medical data to support these claims were provided.
Date Last Revised: 07/13/2006
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): Triglycidyl Isocyanurate.
- Allmaras, S.: Worker exposure to 1,3,5-tryglycidyl isocyanurate (TGIC) in powder paint coating operations. Appl. Occup. Environ. Hyg. 18(3): 151-153, 2003.
- Lindell, B. and Montelius, J: Triglycidyl isocyanurate. Arbete och Hälsa 18: 1-30, 2001.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Coated Glass Fiber Filter (37 mm) Coated with Hydrobromic Acid
maximum volume: 60 Liters maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/ECD
method reference: OSHA Analytical Method (OSHA PV2055)
method classification: Partially Validated
note: OSHA personnel may obtain coated filters from SLTC.
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