Chemical Sampling Information
	Toluene-2,6-diisocyanate
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 2,6-diisocyanato-1-methylbenzene; 2,6-TDI OSHA IMIS Code Number: T177 Chemical Abstracts Service (CAS) Registry Number: 91-08-7 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CZ6310000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2078 156 [27 KB, PDF] Chemical Description and Physical Properties: colorless to yellow liquid with a pungent odor - turns to pale yellow on exposure to air. molecular formula: C9H6N2O2 molecular weight: 174.16 boiling point: 96°C @ 1.5 mm Hg melting point: 8°C Potentially hazardous incompatibilities: This compound reacts violently with water. With limited amounts of water, di-substituted amides are formed; with excess water, 2,4-diaminotoluene is formed. It reacts rapidly with active hydrogen compounds (alcohols, primary and secondary amines and carboxylic acids). It is polymerized rapidly by bases. Exposure Limits American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.005 ppm, 0.036 mg/m3 TWA; 0.02 ppm, 0.14 mg/m3 STEL; SEN; Appendix A4 - Not Classifiable as a Human Carcinogen Health Factors International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans Potential symptoms: Nose, throat irritation; choking, paroxysmal coughing; chest pain; retrosternal soreness; nausea, vomiting, abdominal pain; bronchial spasms; pulmonary edema; wheezing, dyspnea, asthma; conjunctivitis, lacrimation, blurred vision; dermatitis, skin sensitization, pain; (carcinogenic) Health Effects: Respiratory sensitization---Asthma (HE9); Dermatitis (HE3); Irritation-Eye, Nose, Throat, Skin---Marked (HE14) Affected organs: Respiratory system, skin, eyes Note: OSHA has not set exposure limits for 2,6-TDI, despite reports that workers manufacturing polyurethane foam by the continuous slabstock process (the greatest use of TDIs) are exposed to 1-4 times as much 2,6-TDI as 2,4-TDI Date Last Revised: 07/22/2003 Literature Basis: Cummings, B.J. and Booth, K.S.: Industrial hygiene sampling for airborne TDI in six flexible slabstock foam manufacturing facilities in the United States: a comparison of the short-term and long-term sampling data. Appl. Occup. Environ. Hyg. 17(2): 863-871, 2002. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Coated Glass Fiber Filter (37 mm open face) Coated with 1.0 mg 1-(2-Pyridyl)piperazine maximum volume: 240 Liters   maximum flow rate: 1.0 L/min current analytical method: High Performance Liquid Chromatography; HPLC/UV/FLU method reference: OSHA Manual of Analytical Methods (OSHA 42) method classification: Fully Validated note: OSHA personnel may obtain filters from SLTC and refrigerate until used. On-Site Sampling Techniques/Method: device: Detector Tube manufacturer: Dräger model/type: Toluene Diisocyanate 0.02/a, order no. 67 24501 sampling information: 25 strokes upper measurement limit: 0.2 ppm detection limit: approx. 0.02 ppm standard deviation: ±30% method reference: on-site air secondary (manufacturer) All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.