Chemical Sampling Information
	1,1,1,2-Tetrafluoroethane
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Freon 134a; HFA 134a; HFC 134a; Norflurane; Refrigerant R134a; SUVA-134a OSHA IMIS Code Number: R225 Chemical Abstracts Service (CAS) Registry Number: 811-97-2 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KI8842500 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 3159 126 [27 KB, PDF] Chemical Description and Physical Properties: colorless gas with slight ethereal odor molecular formula: C2H2F4 molecular weight: 102.03 boiling point: -26.2°C vapor pressure: 630 kPa @ 25°C melting point: -101°C Health Factors Potential symptoms: Dizziness, drowsiness, dullness; frostbite (on contact with liquid). Health Effects: Narcosis (HE8) Affected organs: CNS, skin Notes: OSHA does not have a PEL for 1,1,1,2-tetrafluoroethane EPA's inhalation reference concentration (daily inhalational exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for 1,1,1,2-tetra-fluoroethane is 80 mg/m3. Because of its use in metered-dose inhalers, 1,1,1,2-tetrafluoroethane has been studied in human volunteers with single-breath inhalation and one-hour exposures to concentrations up to 8000 ppm, which caused no respiratory irritation or adverse effects on pulse, blood pressure, lung function, electrocardiogram or on the CNS. Date Last Revised: 07/28/2006 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): 1,1,1,2-Tetrafluoroethane. U.S. EPA Integrated Risk Information System: 1,1,1,2-Tetrafluoroethane (CASRN 811-97-2). Emmen, H.H., et al.: Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-heptafluoropropane) following whole-body exposure. Regul. Toxicol. Pharmacol. 32(1): 22-35, 2000. Pike, V.W., et al.: Disposition of inhaled 1,1,1,2-tetrafluoroethane (HFA134A) in healthy subjects and in patients with chronic airflow limitation. Measurement by 18F-labeling and whole-body γ-counting. Drug. Metab. Dispos. 23(8): 832-839, 1995. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Two Anasorb CMS tubes in series (150/75 mg sections) analytical solvent: (60:40) DMF:Carbon Disulfide maximum volume: 1 Liter   maximum flow rate: 0.05 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA SLTC In-House File method classification: Not Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.