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Chemical Sampling Information |
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| Temephos (Total Dust) |
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General Description
Synonyms: Abate®; Temefos; O,O,O'O'-Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate; Phosphorothioic acid, O,O-dimethyl ester, O,O-diester with 4,4'-thiodiphenol
OSHA IMIS Code Number: 0005
IMIS Name History: Abate prior to 9/1/89
Chemical Abstracts Service (CAS) Registry Number: 3383-96-8
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: TF6890000
NIOSH Pocket Guide to Chemical Hazards, Temephos: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 15 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 15 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 mg/m3 TWA; Inhalable fraction and vapor. Skin; Appendix A4 - Not Classifiable as a Human Carcinogen; BEI®A - see Acetylcholinesterase Inhibiting Pesticides
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 10 mg/m3 TWA
Health Factors
Potential symptoms: Irritation of eyes, blurred vision; headache, dizziness; dyspnea (breathing difficulty); salivation, sweating; abdominal cramps, nausea, vomiting, diarrhea.
Health Effects: Irritation-Eyes, Nose, Throat, Lungs, Skin---Marked (HE14); Nervous System Disturbances---Cholinesterase inhibition (HE6); Mutagen (HE2); LD50 (Oral, rat) 20 mg/kg
Affected organs: Eyes, respiratory system, CNS, cardiovascular system, blood cholinesterase
Notes: 1) Temephos was reported to be genotoxic and mutagenic in vitro at concentrations similar to those used to control mosquito larvae. 2) Temephos can be absorbed through the skin and is metabolized to an active oxon derivative by the cytochrome P450 system.
Date Last Revised: 09/19/2005
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Temephos.
- International Chemical Safety Cards (WHO/IPCS/ILO): Temephos.
- Aiub, C.A., Coelho, E.C., Sodre, E., Pinto, L.F. and Felzenszwalb, I.: Genotoxic evaluations of the organophosphorus pesticide temephos. Genet. Mol. Res. 1(2): 159-166, 2002.
- Ferguson, P.W., Medon, P.J. and Nasri, E.: Temephos (Abate®) metabolism and toxicity in rats. Arch. Environ. Contam. Toxicol. 14(2): 143-147, 1985.
- Pohanish, R.P. (editor): Temephos. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2148-2150.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Glass Fiber Filter (37 mm)
maximum volume: 60 Liters maximum flow rate: 1.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA PV2056)
method classification: Partially Validated
note: OSHA personnel may obtain sampling medium from SLTC.
Wipe sampling: Yes, with Glass Fiber Filter
Bulk method: Limit the amount of bulk submitted to one gram or one mL.
* All Trademarks are the property of their respective owners.
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Page last updated: 04/11/2006
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