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Isobutyl Acetate

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General Description
    Synonyms: Isobutyl ester of acetic acid; 2-Methylpropyl acetate; 2-Methylpropyl ester of acetic acid; beta-Methylpropyl ethanoate

    OSHA IMIS Code Number: 1534

    Chemical Abstracts Service (CAS) Registry Number: 110-19-0

    NIOSH, Registry of Toxic Effects (RTECS) Identification Number: AI4025000

    Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1213 129 [27 KB, PDF]

    NIOSH Pocket Guide to Chemical Hazards, Isobutyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
    OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 150 ppm, 700 mg/m3 TWA

    OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 150 ppm, 700 mg/m3 TWA

    OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 150 ppm, 700 mg/m3 TWA

    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 150 ppm, 713 mg/m3 TWA

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 150 ppm, 700 mg/m3 TWA
Health Factors
    NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,300 ppm LEL

    Potential symptoms: Irritation of eyes, skin, upper respiratory system; cough, sore throat; headache, dizziness, drowsiness; anesthesia; in animals: narcosis. INGES. ACUTE: nausea.

    Health Effects: Irritation-Eye, Nose, Throat---Moderate (HE15); Narcosis (HE8); Explosive, Flammable (HE18)

    Affected organs: Eyes, skin, respiratory system, CNS

    Notes:
    1. Vapor/air mixtures may be explosive. The IDLH is 10% of the lower explosive limit (1.3%).
    2. Listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515)

    Date Last Revised: 02/08/2006

    Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Isobutyl Acetate.
    • International Chemical Safety Cards (WHO/IPCS/ILO): Isobutyl acetate.
    • Pohanish, R.P. (editor): Butyl Acetates. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 392-395.
Monitoring Methods used by OSHA
    Laboratory Sampling/Analytical Method:

    • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
      analytical solvent: Carbon Disulfide
      maximum volume: 12 Liters   maximum flow rate: 0.05 L/min (TWA)
      maximum volume: 0.75 Liter   maximum flow rate: 0.05 L/min (STEL)
      current analytical method: Gas Chromatography; GC/FID
      method reference: OSHA Analytical Method (OSHA 1009)
      method classification: Fully Validated

    • sampling media: Diffusive Sampler:
      • 3M 3520 Organic Vapor Monitor;
      • SKC 575-002 Passive Sampler
      analytical solvent: Carbon Disulfide
      minimum time: 15 to 240 Minutes
      current analytical method: Gas Chromatography; GC/FID
      method reference: OSHA Analytical Method (OSHA 1009)
      method classification: Fully Validated
      note: Persons using diffusive samplers to monitor workplace air must ensure that the sampling devices are properly closed before transporting such devices to the laboratory for analysis. The device will continue to sample until properly closed. Diffusive sampler accessories used for analysis of samplers must be included with transported samples. Persons using such devices must provide sampling-site station barometric pressure and temperature to the analytical laboratory to improve accuracy of sampling results.

    • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
      analytical solvent: Carbon Disulfide
      alternate analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide
      alternate analytical solvent: (95:5) Methylene Chloride:Methanol
      maximum volume: 10 Liters   maximum flow rate: 0.2 L/min
      current analytical method: Gas Chromatography; GC/FID
      method reference: NIOSH Analytical Method (NIOSH 1450) [107 KB, PDF]
      method classification: Fully Validated
      note: Samples should be refrigerated as soon as possible after sampling and sent cold to the laboratory.

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