The IDLH is 10% of the lower explosive limit (1.7%). Above 22ºC, explosive vapor/air mixtures may be formed.
Listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515).
n-Butyl acetate is metabolized in the body sequentially to n-butanol, n-butyraldehyde, and n-butyric acid. The latter can go into fatty acid synthesis via medium chain acyl-CoA synthetase.
Rats inhaling n-butyl acetate 6 hr/day, 5 days/week for 13 weeks showed degeneration of the olfactory epithelium, judged to be minimum to mild at 1500 ppm and mild to moderate at 3000 ppm levels of exposure. The NOEL was 500 ppm.
International Chemical Safety Cards (WHO/IPCS/ILO): n-Butyl acetate.
David, R.M., Tyler, T.R., Quellette, R., Faber, W.D. and Banton, M.I.: Evaluation of subchronic toxicity of n-butyl acetate vapor. Food Chem. Toxicol.39(8): 877-886, 2001.
Pohanish, R.P. (editor): Butyl Acetates. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 392-395.
Teeguarden, J.G., et al.: Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid. Toxicol. Sci.85(1): 429-446, 2005.
sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 12 Liters maximum flow rate: 0.05 L/min (TWA)
maximum volume: 0.75 Liter maximum flow rate: 0.05 L/min (STEL)
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA 1009)
method classification: Fully Validated
sampling media: Diffusive Sampler:
3M 3520 Organic Vapor Monitor;
SKC 575-002 Passive Sampler
analytical solvent: Carbon Disulfide
minimum time: 15 to 240 Minutes
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA 1009)
method classification: Fully Validated
note: Persons using diffusive samplers to monitor workplace air must ensure that the sampling devices are properly closed before transporting such devices to the laboratory for analysis. The device will continue to sample until properly closed. Diffusive sampler accessories used for analysis of samplers must be included with transported samples. Persons using such devices must provide sampling-site station barometric pressure and temperature to the analytical laboratory to improve accuracy of sampling results.
sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide
maximum volume: 10 Liters maximum flow rate: 0.2 L/min (TWA)
maximum volume: 3 Liters maximum flow rate: 0.2 L/min (STEL)
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 1450) [107 KB, PDF]
method classification: Fully Validated
note: Samples should be refrigerated as soon as possible after sampling and sent cold to the laboratory.
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