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ToxRefDB Program
Toxicology Reference Database
ToxRefDB was developed by the National Center for Computational Toxicology (NCCT) in partnership with EPA’s Office of Pesticide Programs (OPP), to store data from in vivo animal toxicity studies. The initial focus was populating ToxRefDB with pesticide registration toxicity data that has been historically stored as hard-copy and scanned documents by OPP. A significant portion of these data have now been processed into ToxRefDB in a standardized and structured format. ToxRefDB currently includes chronic, cancer, sub-chronic, developmental, and reproductive studies on hundreds of chemicals, many of which are pesticide active ingredients. These data are now accessible and computable within ToxRefDB, and are serving as reference toxicity data for ORD research and OPP retrospective analyses. The primary research appliction of ToxRefDB is to provide toxicity endpoints for the development of ToxCast™ predictive signatures.
| Data Set | Description | Download | Publication |
|---|---|---|---|
| Data Entry Tool & Controlled Vocabulary | The Data Entry Tool provided the user interface for all initial data input into ToxRefDB. The controlled vocabulary standardized the capturing of regulatory animal toxicity studies performed across various study types. (More Information) | Download (15.5 MB, ZIP) | Martin et al. (2008) "Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database" Environmental Health Perspectives doi:10.1289/ehp.0800074 |
| Chronic & Cancer Endpoints | Based on incidence, severity and potency, 26 primarily tissue-specific pathology endpoints were selected to uniformly classify 310 chemicals included in the manuscript's analysis. The 310 chemicals in this analysis largely overlap with the 320 ToxCast Phase I chemicals. (More Information) | Download (2.7 MB, XLS) | Martin et al. (2008) "Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database" Environmental Health Perspectives doi:10.1289/ehp.0800074 |