ToxCast™ Program
Predicting Hazard, Characterizing Toxicity Pathways, and Prioritizing the Toxicity Testing of Environmental Chemicals

ToxCast™ Cooperative Research Partnerships

Chemical Prioritization Community of Practice (CPCP)
Cooperative Research and Development Agreements (CRADA)
- ToxCast™ CRADA announcement
- Illumina Materials CRADA for developing ToxCast™ genomics assays
Interagency Agreements (IAG)

IAG with the NIH Chemical Genomics Center to test chemicals being evaluated in ToxCast™ utilizing quantitative HTS assays.

Material Transfer Agreements (MTA)
- CellzDirect MTA for developing applications of in vitro hepatic models for ToxCast™ (PDF, 5 pp., 265 kb)
- GeneLogic MTA for accessing genomic databases useful to ToxCast™ (PDF, 8 pp., 783 kb)
- Gentronix MTA for developing applications of an HTS genotoxicity assay for ToxCast™ (PDF, 8 pp., 675 kb)
- Invitrogen Discovery Sciences MTA for applying novel HTS assays to ToxCast™ (PDF, 8 pp., 510 kb)
- SimBioSys MTA for applying computational chemistry tools to ToxCast™ (PDF, 3 pp., 203 kb)
- Solidus Biosciences MTA with EPA for developing applications of three-dimensional cellular microarrays for HTS ToxCast™ assays (PDF, 9 pp., 501 kb)
Memorandum of Understanding (MOU)
- The Hamner Institutes for Health Sciences MOU with EPA for collaborative research on ToxCast™ chemicals and assays (PDF, 6 pp., 360 kb)
- MOU on HTS and toxicity pathway profiling between the U.S. National Toxicology Program (NTP), the NIH Chemical Genomics Center (NCGC), and EPA, encompassing collaborative research on ToxCast™ chemicals and assays that complements the EPA-NCGC IAG.
Tox21 Partnership
- Tox21 Assay Nominations (PDF, 2 pp., 15 kb)