Award Abstract #0114795
Arabidopsis 2010: The Arabidopsis RPM1 Disease Resistance Signaling Network

NSF Org:	IOS Division of Integrative Organismal Systems
Initial Amendment Date:	August 20, 2001
Latest Amendment Date:	September 22, 2005
Award Number:	0114795
Award Instrument:	Continuing grant
Program Manager:	Michael L. Mishkind IOS Division of Integrative Organismal Systems BIO Directorate for Biological Sciences
Start Date:	September 1, 2001
Expires:	August 31, 2006 (Estimated)
Awarded Amount to Date:	$1274302
Investigator(s):	Jeffery Dangl dangl@email.unc.edu (Principal Investigator)
Sponsor:	University of North Carolina at Chapel Hill 104 AIRPORT DR STE 2200 CHAPEL HILL, NC 27599 919/966-3411
NSF Program(s):	BEHAVIORAL SYSTEMS CLUSTER, INTEGRATIVE PLANT BIOLOGY, SIGNAL TRANSDCTN/CELL REGULATN
Field Application(s):	0000099 Other Applications NEC
Program Reference Code(s):	SMET, BIOT, 9251, 9184, 9183, 9178, 9109, 1684, 1164, 1145, 1136
Program Element Code(s):	7472, 1145, 1136

ABSTRACT

Determining the function of a network of genes

Definition of "determining the function"

In our project, we will define the function of approximately 10 new genes from Arabidopsis that are functionally related because they are part of the RPM1 disease resistance pathway. Our definition of function will entail:

1. Detailed information on the role of these genes in disease resistance.

2. Broader definition of extra functions that we may uncover for these genes. For example, we already know that reduction of function of at least two of them causes meristem defects. At present, this may be simple pleiotropy. It also may be relevant, meaning that the genes in question have additional functions in plant growth.

URLs where the public can get information on their accession numbers in GenBank or other identifiers in a publicly accessible database

Our data will be published and our results will also be available on our lab web site at:

http://www.bio.unc.edu/faculty/dangl/lab/superpage.html

As an example of how we release web based data, see:

http://www.bio.unc.edu/faculty/dangl/lab/sar/

What, how and where the results will be shared

We will share our results well before publication at the annual Arabidopsis meeting.

Significance of the proposed work in relation to the 2010 Project objectives

Our work will dovetail with more general functional genomics proposals funded in 2010. It is necessary to incorporate hypothesis driven functional genomics results, such as the data we intend to generate, with the gene family and whole genome data generated by others.

Broader Impact

Disease resistance is a significant problem in agriculture. We will add to the body of knowledge that will eventually lead to more effective control of plant disease. This is vital because we currently lose up to 30% of crop yield to pathogens and pests.

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