[Code of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.35]

[Page 333]
 
                   TITLE 40--PROTECTION OF ENVIRONMENT
 
         CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)
 
PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE CHEMICALS 
IN FOOD--Table of Contents
 
                    Subpart B_Procedural Regulations
 
Sec. 180.35  Tests for potentiation.

    Experiments have shown that certain cholinesterase-inhibiting 
pesticides when fed together to test animals are more toxic than the sum 
of their individual toxicities when fed separately. One substance 
potentiates the toxicity of the other. Important toxicological 
interactions also have been observed between pesticides and other 
substances. Wherever there is reason to believe that a pesticide 
chemical for which a tolerance is proposed may interact with other 
pesticide chemicals or other substances to which man is exposed, it may 
be necessary to require special experimental data regarding potentiation 
capacities to evaluate the safety of the proposed tolerance. This 
necessarily will be determined on a case-by-case basis.