[Code of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.3]

[Page 318-322]
 
                   TITLE 40--PROTECTION OF ENVIRONMENT
 
         CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)
 
PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE CHEMICALS 
IN FOOD--Table of Contents
 
          Subpart A_Definitions and Interpretative Regulations
 
Sec. 180.3  Tolerances for related pesticide chemicals.

    (a) Pesticide chemicals that cause related pharmacological effects 
will be regarded, in the absence of evidence to the contrary, as having 
an additive deleterious action. (For example, many pesticide chemicals 
within each of the following groups have related pharmacological 
effects: Chlorinated organic pesticides, arsenic-containing chemicals, 
metallic dithiocarbamates, cholinesterase-inhibiting pesticides.)
    (b) Tolerances established for such related pesticide chemicals may 
limit the amount of a common component (such as 
As2O3) that may be present, or may limit the 
amount of biological activity (such as cholinesterase inhibition) that 
may be present, or may limit the total amount of related pesticide 
chemicals (such as chlorinated organic pesticides) that may be present.
    (c)(1) Where tolerances for inorganic bromide in or on the same raw 
agricultural commodity are set in two or more sections in this part 
(example: Sec. Sec. 180.123 and 180.199), the overall quantity of 
inorganic bromide to be tolerated from use of the same pesticide in 
different modes of application or from two or more pesticide chemicals 
for which tolerances are established is the highest of the separate 
applicable tolerances. For example, where the bromide tolerance on 
asparagus from methyl bromide commodity fumigation

[[Page 319]]

is 100 parts per million (40 CFR 180.123) and on asparagus from methyl 
bromide soil treatment is 300 parts per million (40 CFR 180.199), the 
overall inorganic bromide tolerance for asparagus grown on methyl 
bromide-treated soil and also fumigated with methyl bromide after 
harvest is 300 parts per million.
    (2) Where tolerances are established in terms of inorganic bromide 
residues only from use of organic bromide fumigants on raw agricutural 
commodities, such tolerances are sufficient to protect the public 
health, and no additional concurrent tolerances for the organic 
pesticide chemicals from such use are necessary. This conclusion is 
based on evidence of the dissipation of the organic pesticide or its 
conversion to inorganic bromide residues in the food when ready to eat.
    (d)(1) Where tolerances are established for both calcium cyanide and 
hydrogen cyanide on the same raw agricultural commodity, the total 
amount of such pesticides shall not yield more residue than that per 
mitted by the larger of the two tol er ances, calculated as hydrogen 
cyanide.
    (2) Where tolerances are established for residues of both O,O-
diethyl S-[2-(ethylthio)ethyl] phosphorodithioate and demeton (a mixture 
of O,O-diethyl O-(and S-) [2-(ethylthio)ethyl] phos phor o thi oates) on 
the same raw agricultural commodity, the total amount of such pes ti 
cides shall not yield more residue than that permitted by the larger of 
the two tolerances, calculated as demeton.
    (3) Where tolerances are established for both terpene 
polychlorinates (chlorinated mixture of camphene, pinene, and related 
terpenes, containing 65-66 percent chlorine) and toxaphene (chlorinated 
camphene containing 67-69 percent chlorine) on the same raw agricultural 
commodities, the total amount of such pesticides shall not yield more 
residue than that permitted by the larger of the two tolerances, 
calculated as a chlorinated terpene of molecular weight 396.6 containing 
67 percent chlorine.
    (4) Where a tolerance is established for more than one pesticide 
containing arsenic found in, or on a raw agricultural commodity, the 
total amount of such pesticide shall not exceed the highest established 
tolerance calculated as As2O3.
    (5) Where tolerances are established for more than one member of the 
class of dithiocarbamates listed in paragraph (e)(3) of this section on 
the same raw agricultural commodity, the total residue of such 
pesticides shall not exceed that permitted by the highest tolerance 
established for any one member of the class, calculated as zinc 
ethylenebisdithiocarbamate.
    (6) Where tolerances are established for residues of both S,S,S-
tributyl phosphorotrithioate and tributyl phosphorotrithioite in or on 
the same raw agricultural commodity, the total amount of such pesticides 
shall not yield more residue than that permitted by the higher of the 
two tolerances, calculated as S,S,S-tributyl phos phor o tri thi oate.
    (7) Where tolerances are established for residues of [alpha]-
naphthaleneacetamide and/or [alpha]-naphthaleneacetic acid in or on the 
same raw agricultural com mod i ty, the total amount of such pesticides 
shall not yield more residue than that permitted by the higher of the 
two tol er ances, calculated as [alpha]-naphth alen e acetic acid.
    (8) Where tolerances are established for residues of O,S-dimethyl 
phos phor a mid o thi oate, resulting from the use of acephate (O,S-di 
methyl acetyl phos-phor a mid o thi oate) and/or O,S - dim ethyl phos 
phor a mid o thi oate on the same agricultural commodity, the total 
amount of O,S-di methyl-phos phor a mid o thi oate shall not yield more 
residue than that permitted by the higher of the two tolerances.
    (9) Where a tolerance is established for more than one pesticide 
having the metabolites 1-(3,4-dichlorophenyl)-3-methylurea (DCPMU) and 
3,4-dichlorophenylurea (DCPU) found in or on a raw agricultural 
commodity, the total amount of such residues shall not exceed the 
highest established tolerance for a pesticide having these metabolites.
    (10) Where a tolerance is established for more than one pesticide 
having as metabolites compounds containing the benzimidazole moiety 
found in or on a raw agricultural commodity, the total amount of such 
residues shall not exceed the highest established tolerance

[[Page 320]]

for a pesticide having these me tab o lites.
    (11) Where a tolerance is established for triclopyr, chloropyrifos, 
and chlorpyrifos-methyl having the common metabolite 3,5,6-trichloro-2-
py rid i nol on the same raw agricultural commodity, the total amount of 
such residues shall not exceed the highest established tolerance for any 
of the pesticides having the me tab o lites.
    (12) Where tolerances are established for more than one pesticide 
having the metabolite 3,5,6-trichloro-2-pyridinol found in or on the raw 
agricultural commodity, the total amount of such residues shall not 
exceed the highest established tolerance for a pesticide having this 
metabolite.
    (13) Where tolerances are established for residues of both 1-(4-
chlor o phe noxy)-3,3-di methyl-1-(1H-1,2,4-tri a zol-1-yl)-2-bu ta none 
(tri adime fon) and beta-(4-chlor o phe noxy)-al pha-(1,1-di methyl 
ethyl)-1H-1,2,4-tri a zole-1-eth a nol (tri adi me nol) including its bu 
ta ne diol me tab o lite, 4-(4-chlor o phe noxy)-2,2-di methyl-4-(1H-
1,2,4-tri a zol-1-yl)-1,3-bu ta ne diol, in or on the same raw 
agricultural commodity and its products thereof, the total amount of 
such residues shall not yield more residue than that permitted by the 
higher of the two tolerances.
    (14) Where tolerances are established for residues of methomyl, 
resulting from the use of thiodicarb and/or methomyl on the same raw 
agricultural commodity, the total amount of methomyl shall not yield 
more residue than that permitted by the higher of the two tolerances.
    (e) Except as noted in paragraphs (e)(1) and (2) of this section, 
where residues from two or more chemicals in the same class are present 
in or on a raw agricultural commodity the tolerance for the total of 
such residues shall be the same as that for the chemical having the 
lowest numerical tolerance in this class, unless a higher tolerance 
level is specifically provided for the combined residues by a regulation 
in this part.
    (1) Where residues from two or more chemicals in the same class are 
present in or on a raw agricultural commodity and there are available 
methods that permit quantitative determination of each residue, the 
quantity of combined residues that are within the tolerance may be 
determined as follows:
    (i) Determine the quantity of each residue present.
    (ii) Divide the quantity of each residue by the tolerance that would 
apply if it occurred alone, and multiply by 100 to determine the 
percentage of the permitted amount of residue present.
    (iii) Add the percentages so obtained for all residues present.
    (iv) The sum of the percentages shall not exceed 100 percent.
    (2) Where residues from two or more chemicals in the same class are 
present in or on a raw agricultural commodity and there are available 
methods that permit quantitative determinations of one or more, but not 
all, of the residues, the amounts of such residues as may be 
determinable shall be deducted from the total amount of residues present 
and the remainder shall have the same tolerance as that for the chemical 
having the lowest numerical tolerance in that class. The quantity of 
combined residues that are within the tolerance may be determined as 
follows:
    (i) Determine the quantity of each determinable residue present.
    (ii) Deduct the amounts of such residues from the total amount of 
residues present and consider the remainder to have the same tolerance 
as that for the chemical having the lowest numerical tolerance in that 
class.
    (iii) Divide the quantity of each determinable residue by the 
tolerance that would apply if it occurred alone and the quantity of the 
remaining residue by the tolerance for the chemical having the lowest 
numerical tolerance in that class and multiply by 100 to determine the 
percentage of the permitted amount of residue present.
    (iv) Add the percentages so obtained for all residues present.
    (v) The sum of the percentages shall not exceed 100 percent.
    (3) The following pesticides are members of the class of 
dithiocarbamates:

A mixture of 5.2 parts by weight of ammoniates of [ethylenebis 
(dithiocarbamato)] zinc with 1 part by weight ethylenebis 
[dithiocarbamic acid] bimolecular and trimolecular cyclic 
anhydrosulfides and disulfides.
2-Chloroallyl diethyldithiocarbamate.

[[Page 321]]

Coordination product of zinc ion and maneb containing 20 percent 
manganese, 2.5 percent zinc, and 77.5 percent ethyl ene bis dith i o car 
ba mate.
Ferbam.
Maneb.
Manganous dimethyldithiocarbamate.
Sodium dimethyldithiocarbamate.
Thiram.
Zineb.
Ziram.

    (4) The following are members of the class of chlorinated organic 
pesticides:

Aldrin.
BHC (benzene hexachloride).
1,1-Bis(p-chlorophenyl)-2,2,2-trichloro ethanol.
Chlorbenside (p-chlorobenzyl p-chlor o phenyl sul fide).
Chlordane.
Chlorobenzilate (ethyl 4,4'-di chlor o ben zi late).
p-Chlorophenoxyacetic acid.
p-Chlorophenyl-2,4,5-trichlorophenyl sulfide.
2,4-D (2,4-dichlorophenoxyacetic acid).
DDD (TDE).
DDT.
1,1-Dichloro-2,2-bis(p-ethylphenyl) ethane.
2,6-Dichloro-4-nitroaniline.
2,4-Dichlorophenyl p-nitrophenyl ether.
Dieldrin.
Dodecachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalene.
Endosulfan (6,7,8,9,10,10-hexachloro-1,5,5a, 6,9,9a-hexahydro-6,9-
methano-2,4,3-ben zo di oxathie pin-3-ox ide).
Endosulfan sulfate (6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-
6,9-methano-2,4,3-benzodioxathiepin-3,3-dioxide).
Heptachlor (1,4,5,6,7,8,8-heptachlor-3a,4,7, 7a-tetrahydro-4,7-
methanoindene).
Heptachlor epoxide (1,4,5,6,7,8,8-heptachloro-2,3-epoxy-2,3,3a,4,7,7a-
hexahydro-4,7-methanoindene).
Hexachlorophene (2,2'-methylenebis(3,4,6-trichlorophenol) and its 
monosodium salt.
Isopropyl 4,4'-dichlorobenzilate.
Lindane.
Methoxychlor.
Ovex (p-chlorophenyl p-chlorobenzene sulfonate).
Sesone (sodium 2,4-dichlorophenoxyethyl sulfate, SES).
Sodium 2,4-dichlorophenoxyacetate.
Sodium trichloroacetate.
Sulphenone (p-chlorophenyl phenyl sul fone).
Terpene polychlorinates (chlorinated mixture of camphene, pinene, and 
related terpenes 65-66 percent chlorine).
2,3,5,6-Tetrachloronitrobenzene.
Tetradifon (2,4,5,4'-tetrachlorodiphenyl sul fone).
Toxaphene (chlorinated camphene).
Trichlorobenzoic acid.
Trichlorobenzyl chloride.

    (5) The following are members of the class of cholinesterase-
inhibiting pesticides:

Acephate (O,S-dimethyl acetyl-phos phor a mid o thi oate) and its cho 
lines ter ase-inhibiting meta bo lite O,S-di methyl phos phor a mid o 
thi oate.
Aldicarb (2-methyl-2-(methylthio) pro pional de hyde O-(methyl car ba 
moyl)ox ime) and its chlor ines ter ase-inhibiting met a bo lites 2-
methyl-2-(methyl sul finyl)pro pional de hyde O-(methy car ba moyl) ox 
ime and 2-methyl-2-(methyl sul fonyl)pro pional de hyde O-(methyl car ba 
moyl)ox ime.
4-tert-Butyl-2-chlorophenyl methyl meth yl phosphoramidate.
S-[(tert-Butylthio)methyl] O,O-diethyl phos phor o dith i oate and its 
cho lines ter ase-inhibiting me tab o lites.
Carbaryl (1-naphthyl N-methylcarbamate).
Carbofuran (2,3,-dihydro-2,2-dimethyl-7-ben zo fur anyl-N-methyl car ba 
mate).
Carbofuran metabolite (2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benofuranyl 
N-methyl car ba mate).
Carbophenothion (S-[(p-chlorophenyl) thi ol methyl] O,O-di ethyl phos 
phor o dith i oate) and its cho lines ter ase-inhibiting me tab o lites.
Chlorpyrifos (O,O-diethyl O-(3,5,6-tri chloro-2-
pyridyl)phosphorothioate).
Chlorpyrifos-methyl (O,O-dimethyl-O-(3,5,6-trichloro-2-pyridyl) 
phosphorothioate.
2-Chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate.
2-Chloro-1-(2,4-dichlorophenyl) vinyl di ethyl phosphate.
Coumaphos (O,O-diethyl O-3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl 
phosran-7-yl phosphate).
Coumaphos oxygen analog (O,O-diethyl O-3-chloro-4-methyl-2-oxo-2H-1-ben 
zo py phor o thi oate).
Dialifor (S-(2-chloro-1-phthalimidoethyl) O,O-diethyl 
phosphorodithioate).
Dialifor oxygen analog (S-(2-chloro-1-phth al i mi do ethyl) O,O-di 
ethyl phos phor o thi oate).
Demeton (a mixture of O,O-diethyl O-(and S) [2-ethylthio)ethyl] 
phosphorothioates).
Ethiolate (S-ethyl diethylthiocarbamate).
2,2-Dichlorovinyl dimethyl phosphate.
O,O-Diethyl S-[2-(ethylthio)ethyl] phos phor o dith i oate and its cho 
lines ter ase-inhibiting me tab o lites.
O,O-Diethyl O-(2-diethylamino-6-methyl-4-pyrimidinyl) phosphorothioate 
and its oxygen analog diethyl 2-diethylamino-6-methyl-4-pyrimidinyl 
phosphate.
O,O-Diethyl O-(2-isoprophyl-4-methyl-6-pyrimidinyl) phosphorothioate.
O,O-Diethyl O-[p-(methylsulfinyl)phenyl] phosphorothioate and its 
cholinesterase-inhibiting metabolites.
Diethyl 2-pyrazinyl phosphate.
O,O-Diethyl O-2-pyrazinyl phosphorothi oate.

[[Page 322]]

S-(O,O-Diisopropyl phosphorodithioate) of N-(2-mercaptoethyl) 
benzenesulfonamide
S-(O,O-Diisopropyl phosphorodithioate) of N-(2-mercaptoethyl) 
benzenesulfonamide
2-(Dimethylamino)-5.6-dimethyl-4-pyrimidinyl dimethylcarbamate and its 
metabolites 5,6-dimethyl-2-(formyl meth yl amino)-4-pyr i mid inyl 
dimethyl car ba mate and 5,6-dimethyl-2-(meth yl amino)-4-pyrimidinyl di 
meth yl car ba mate (both calculated as parent).
Dimethoate (O,O-dimethyl S-(N-methyl-carbamoylmethyl) 
phosphorodithioate).
Dimethoate oxygen analog (O,O-dimethyl S-(N-methylcarbamoylmethyl) 
phosphorothioate).
O,O-Dimethyl O-p-(dimethylsulfamoyl) phenyl phosphate.
O,O-Dimethyl O-p-(dimethylsulfamoyl) phenyl phosphorothioate.
3,5-Dimethyl-4-(methylthio) phenyl meth yl carbamate.
O,O-Dimethyl S-[4-oxo-1,2,3-benzotriazin-3-(4H)-ylmethyl] 
phosphorodithioate.
Dimethyl phosphate of 3-hydroxy-N,N-dimethyl-cis-crotonamide.
Dimethyl phosphate of 3-hydroxy-N-methyl-cis-crotonamide.
Dimethyl phosphate of [alpha]-methylbenzyl 3-hydroxy-cis-crotonate.
O,O-Dimethyl 2,2,2-trichloro-1-hydroxy eth yl phosphonate.
O,O-Dimethyl phosphorodithioate, S-ester with 4-(mercaptomethyl)-2-
methozy-[Delta]2-1,3,4-thiadiazolin-5-one.
Dioxathion (2,3-p-dioxanedithiol S,S-bis (O,O-
diethylphosphorodithioate)) containing approximately 70 percent cis and 
trans isomers and approximately 30 percent related compounds.
EPN.
Ethephon ((2- - chloroethyl) phosphonic acid).
Ethion.
Ethion oxygen analog (S-[[(di eth oxy phos phin oth ioyl)thio] methyl] 
O,O-di ethyl phos phor o thi oate).
O- Ethyl O-[4-(methylthio) phenyl] S-propyl phosphorodithioate and its 
cholinesterase-inhibiting metabolites.
O-Ethyl S,S-dipropylphosphorodithioate.
Ethyl 3-methyl-4-(methylthio)phenyl (1-methylethyl) phosphoramidate and 
its cholinesterase-inhibiting metabolites.
O-Ethyl S-phenyl ethylphosphonodithi oate.
O-Ethyl S-phenyl ethylphosphonothi olate.
m-(1-Ethylpropyl)phenyl methylcarbamate.
S-[2-Ethylsulfinyl)ethyl] O,O-dimethyl phos phor o thi oate and its cho 
lines ter ase-inhibiting me tab o lites, (primarily S-[2-(ethyl-sul 
fonyl)ethyl] O,O-di methyl phos phor o thi oate).
Fenthion (O,O-dimethyl O-[3-methyl-4-(methylthio)phenyl]phosphorothioate 
and its cholinesterase-inhibiting metabolites.
Malathion.
N-(Mercaptomethyl)phthalimide S-(O,O-dimethyl phosphorodithioate).
N-(Mercaptomethyl)phthalimide S-(O,O-dimethyl phosphorothioate).
Methomyl (S-methyl N-[(methyl car bam oyl)oxy]thioacetimidate).
1-Methoxycarbonyl-1-propen-2-yl dimet hyl phosphate and its beta isomer.
m-(1-Methylbutyl)phenyl methylcar ba mate.
Methyl parathion.
Naled (1,2-dibromo-2,2-dichloroethyl dimethyl phosphate).
Oxamyl (methyl N',N'-dimethyl-N-[(meth yl carbamoyl)oxy]-1-
thiooxamimidate)
Parathion.
Phorate (O,O-diethyl S-(ethylthio)methyl phosphorodithioate) and its 
cholinesterase-inhibiting metabolites.
Phosalone (S-(6-chloro-3-mercaptomethyl)-2-benzoxazolinone) O,O-diethyl 
phos phoro dithioate).
Phosphamidon (2-chloro-2-diethylcarba moyl-1-methylvinyl dimethyl 
phosphate) including all of its related cholinesterase-inhibiting 
compounds.
Pirimiphos-methyl O-[2-diethylamino-6-methyl-pyrimidinyl) O,O-dimethyl 
phos pho rothioate
Ronnel.
Schradan (octamethylpyrophosphoramide).
Tetraethyl pyrophosphate.
O,O,O',O'-Tetramethyl O,O'-sulfinyldi-p-phenylene phosphorothioate.
O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate.
Tributyl phosphorotritlioite.
S,S,S-Tributyl phosphorothrithioate.
3,4,5-Trimethylphenyl methylcarbamate and its isomer 2,3,5-
trimethylphenyl meth ylcarbamate.

    (6) The following pesticides are members of the class of 
dinitrophenols:

2,4-Dinitro-6-octylphenyl crotonate and 2,6-dinitro-4-octylphenyl 
crotonate, mixture of.
4,6-Dinitro-o-cresol and its sodium salt.
Dinoseb (2-sec-butyl-4,6-dinitrophenol) and its alkanolamine, ammonium, 
and sodium salts.

[41 FR 8969, Mar. 2, 1976, as amended at 41 FR 10605, Mar. 12, 1976; 41 
FR 20660, May 20, 1976; 41 FR 51401, Nov. 22, 1976; 42 FR 6582, Feb. 3, 
1977; 43 FR 12682, Mar. 27, 1978; 49 FR 44465, Nov. 7, 1984; 49 FR 
45852, Nov. 21, 1984; 50 FR 18485, May 1, 1985; 50 FR 26684, June 27, 
1985; 51 FR 28228, Aug. 6, 1986; 54 FR 31835, Aug. 2, 1989; 57 FR 1649, 
Jan. 15, 1992; 58 FR 65555, Dec. 15, 1993]