• Laperriere N, Perry J, Zuraw L, Neuro-Oncology Disease Site Group. Radiotherapy for newly diagnosed malignant glioma in adults: a clinical practice guideline. Toronto (ON): Cancer Care Ontario (CCO); 2005 Nov 2. 32 p. (Evidence-based series; no. 9-3). [87 references]

• Postoperative external beam radiotherapy is recommended as standard therapy.
• The high-dose volume should incorporate the enhancing tumour plus a limited margin (e.g., 2 cm) for the planning target volume, and the total dose delivered should be 60 Gy in 2 Gy fractions, with concurrent temozolomide at 75 mg/m².
• Radiation dose intensification and radiation sensitizer approaches are not recommended as standard care.

None provided

The recommendations are supported by randomized controlled trials and meta-analyses.

• Laperriere N, Perry J, Zuraw L, Neuro-Oncology Disease Site Group. Radiotherapy for newly diagnosed malignant glioma in adults: a clinical practice guideline. Toronto (ON): Cancer Care Ontario (CCO); 2005 Nov 2. 32 p. (Evidence-based series; no. 9-3). [87 references]

Not applicable: The guideline was not adapted from another source.

2000 Sep 19 (revised 2005 Nov 2)

Program in Evidence-based Care - State/Local Government Agency [Non-U.S.]

The Program in Evidence-based Care (PEBC) is a Province of Ontario initiative sponsored by Cancer Care Ontario and the Ontario Ministry of Health and Long-Term Care.

Cancer Care Ontario
Ontario Ministry of Health and Long-Term Care

Provincial Neuro-oncology Disease Site Group

Not stated

None available

This NGC summary was completed by ECRI on May 14, 2004. The information was verified by the guideline developer on June 2, 2004. This NGC summary was updated by ECRI on September 27, 2004. The updated information was verified by the guideline developer on October 20, 2004. This NGC summary was updated on June 8, 2006. The updated information was verified by the guideline developer on June 26, 2006.