NIAID HIV/OI Searchable Chemical Database

Cellular Targets

Electron micrograph of HIV-1(IIIB) chronically infected H9 cell. (courtesy of Dr. Jacquelline Muller, FDA, CBER).

• Cellular Receptors

  • Immunoglobulin Superfamily

    • CD4

  • Chemokine (Seven-transmembrane) Receptor Superfamily

    • CXCR4 (also known as Fusin; LESTR; NPY3R)
    • CCR5 (also known as CKR-5; CMKRB5)
    • CCR3 (also known as CC-CKR-3; CKR-3; CMKBR3)
    • CCR2 (also known as CCR2b; CMKBR2)
    • CCR1 (also known as CKR1; CMKBR1)
    • CCR4 (also known as CKR-4)
    • CCR8 (also known as ChemR1; TER1; CMKBR8)
    • CCR9 (also known as D6)
    • CXCR2 (also known as IL-8RB)
    • STRL33 (also known as Bonzo; TYMSTR)
    • US28
    • V28 (also known as CMKBRL1; CX₃CR1; GPR13)
    • gpr1 (also known as GPR1)
    • gpr15 (also known as BOB; GPR15)
    • Apj (also known as angiotensin-receptor-like; AGTRL1)
    • ChemR23

  • Miscellaneous Cell Surface Molecules

    • CD26
    • Heparan Sulfate Proteoglycans
    • Galactoceramides
    • Erythrocyte-expressed Glycolipids
    • Other Cell Surface Molecules

• Intracellular Targets

  • Cellular Enzymes

    • N-myristoyltransferase
    • Glycosylation Enzymes
    • gp-160 Processing Enzymes
    • Ribonucleotide Reductase
    • Polyamine Biosynthesis

  • Cellular Transcription Factors

    • Sp1
    • NF-kB

  • Cytokines and Second Messengers

    • Tumor Necrosis Factor-a (TNF-a)
    • Interleukin 1a (IL-1a)
    • Interleukin 6 (IL-6)
    • Phospholipase C
    • Protein Kinase C
    • Intracellular Calcium

  • Cellular Accessory Molecules

    • Cyclophilins
    • MAP-Kinase (Mitogen Activated Protein Kinase)
    • ERK-Kinase (Extracellular Signal-Regulated Kinase)