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A BIOINFORMATIC STRATEGY TO RAPIDLY CHARACTERIZE CDNA LIBRARIES |
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A Bioinformatic Strategy to Rapidly Characterize cDNA Libraries
G. Charles Ostermeier1, David J. Dix2 and Stephen A. Krawetz1.
1Departments of Obstetrics and Gynecology, ...
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A CROSS-SPECIES APPROACH TO USING GENOMICS TOOLS IN AQUATIC TOXICOLOGY |
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Microarray technology has proven to be a useful tool for analyzing the transcriptome of various organisms representing conditions such as disease states, developmental stages, and ...
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A DATABASE FOR TRACKING REPRODUCTIVE TOXICOGENOMIC DATA |
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A Database for Tracking Reproductive Toxicogenomic Data
Wenjun Bao, Judy Schmid, Amber Goetz, Hongzu Ren and David Dix
Reproductive Toxicology Division, National Health and ...
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A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES |
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Reproductive toxicogenomic studies generate large amounts of toxicological and genomic data. On the toxicology side, a substantial quantity of data accumulates from conventional en...
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A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES WITH GENOMIC, PROTEOMIC AND METABONOMIC COMPONENTS |
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A Database for Tracking Toxicogenomic Samples and Procedures with Genomic, Proteomic and Metabonomic Components
Wenjun Bao1, Jennifer Fostel2, Michael D. Waters2, B. Alex Merri...
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A FRAMEWORK FOR THE USE OF GENOMICS DATA AT THE EPA |
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Four year ago, the US Environmental Protection Agency's (EPA) paper Potential Implications of Genomics for Regulatory and Risk Assessment Applications at EPA identified four areas ...
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ACTIVITIES TO DEVELOP AN INTERIM GUIDANCE FOR MICROARRAY-BASED ASSAYS FOR REGULATORY AND RISK ASSESSMENT APPLICATIONS AT EPA |
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Abstract for presentation. Advances in genomics will have significant implications for risk assessment policies and regulatory decision making. In 2002, EPA issued its lnterim Poli...
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ADVANCED COMPUTATIONAL METHODS IN DOSE MODELING: APPLICATION OF COMPUTATIONAL BIOPHYSICAL TRANSPORT, COMPUTATIONAL CHEMISTRY, AND COMPUTATIONAL BIOLOGY |
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Computational toxicology (CompTox) leverages the significant gains in computing power and computational techniques (e.g., numerical approaches, structure-activity relationships, ...
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AGE-RELATED SUSCEPTIBILITY: A GENOMICS APPROACH. |
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By the year 2030 more than 70 million Americans will be over the age of 65. These older adults are a subpopulation that may have special susceptibility to toxic insult due to crit...
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ALTERATIONS IN THE TRANSCRIPTOME AND PROTEOME OF ZEBRAFISH (DANIO RERIO) EXPOSED TO FADRAZOLE, A MODEL AROMATASE INHIBITOR |
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Presentation will provide state-of-the-art information on results of genomics work with two small fish models, the fathead minnow and zebrafish....
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AN ECOLOGICAL PERSPECTIVE OF GENOMICS: ASSESSING ECOLOGICAL RISK THROUGH PARTNERSHIPS |
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The application of new molecular biological tools to environmental toxicology was discussed at an international workshop attended by
approximately 60 government, academic, and i...
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AN ECOLOGICAL PERSPECTIVE OF GENOMICS: ASSESSING ECOLOGICAL RISK THROUGH PARTNERSHIPS |
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A workshop attended by approximately 60 scientists from around the world met to discuss the application of new molecular biology tools to issues in environmental toxicology and che...
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AN ECOLOGICAL PERSPECTIVE OF GENOMICS: PROBLEM FORMULATION |
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n March 2001, an International Council of Chemical Associates sponsored workshop on genomics was held in Orlando, Florida. The objective of the workshop was to review the state-of-...
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ANALYSIS OF TOLUENE AT DIFFERENT LIFE STAGES IN BROWN NORWAY RATS. |
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Differential susceptibility to environmental exposures in subsets of the population is a major regulatory concern of the Environmental Protection Agency. Of special interest is th...
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APPLICATION OF GENOMICS TO REPRODUCTIVE TOXICOLOGY: WORKING FROM RESEARCH TOWARDS RISK ASSESSMENT |
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Genomic technologies are available to examine the expression of thousands of genes simultaneously. These technologies represent a paradigm shift from single-gene approaches fundam...
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APPLICATION OF PROTEOMIC METHODS TO ARSENIC EXPOSURE RESEARCH |
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Arsenic, an environmental contaminant, is introduced to drinking water through the leaching of soil and the result of anthropogenic sources such as industrial effluents and combust...
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APPROACHES IN PROTEOMICS AND GENOMICS FOR ECO-TOXICOLOGY |
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A new area of scientific investigation, coined toxicogenomics, enables researchers to understand and study the interaction between the environment and inherited genetic characteris...
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ASSAY DEVELOPMENT TO EVALUATE THE EFFECT OF SEX HORMONE AGONISTS AND ANTAGONISTS IN FATHEAD MINNOWS |
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Presentation will provide state-of-the-art information on results of genomics work with fathead minnows exposed to endocrine-disrupting chemicals....
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BACTERIAL SOURCE TRACKING |
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Fecal contamination of surface waters used for recreation, drinking water and aquaculture are a continuous environmental problem and pose significant human health risks. An alarmin...
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BACTERIAL SOURCE TRACKING |
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Fecal contamination of surface waters used for recreation, drinking water and aquaculture are a continuous environmental problem and pose significant human health risks. An alarmi...
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BIOMONITORING: INTERPRETATION AND USES |
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With advanced technologies, it is now possible to measure very low levels of many chemicals in biological fluids. However, the appropriate use and interpretation of biomarkers wil...
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CARCINOGENIC EFFECTS OF LOW DOSES OF IONIZING RADIATION |
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Carcinogenic Effects of Low Doses of Ionizing Radiation
R Julian Preston, Environmental Carcinogenesis Division, NHEERL, U.S. Environmental Protection Agency, Research Trian...
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CHALLENGES FOR THE FUTURE IN ENVIRONMENTAL MUTAGENESIS |
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CHALLENGES FOR THE FUTURE IN ENVIRONMENTAL MUTAGENESIS
Michael D. Waters
US Environmental Protection Agency, MD-51A, Research Triangle Park, NC 27711 USA
Our rapi...
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CHANGES IN GENE AND PROTEIN EXPRESSION IN ZEBRAFISH (DANIO RERIO) FOLLOWING EXPOSURE TO ENVIRONMENTALLY-RELEVANT ENDOCRINE-DISRUPTING CHEMICALS (EDCS) |
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This presentation will provide state-of-the-art information on results of genomics work with two small fish models, the fathead minnow and zebrafish....
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CHANGES IN NEUROTRANSMITTER GENE EXPRESSION IN THE AGING RETINA. |
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To understand mechanisms of neurotoxicity in susceptible populations, we examined age-related changes in constitutive gene expression in the retinas of young (4mos), middle-aged (1...
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CHAPTER 4. Application of Genomics to Regulatory Ecological Risk Assessments for Pesticides |
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Development of conceptual framework concerning how genomic data could effectively impact different types of ecological risk assessments in both the short and long term....
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CHIP, CHIP, ARRAY! THREE CHIPS FOR POST-GENOMIC RESEARCH |
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Cambridge Healthtech Institute recently held the 4th installment of their popular "Lab-on-a-Chip" series in Zurich, Switzerland. As usual, it was enthusiastically received and ove...
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CHIPPING AWAY AT THE MYSTERY OF DRUG RESPONSES |
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Chipping away at the mystery of drug responses
John C. Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Rese...
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CLOFIBRATE-INDUCED GENE EXPRESSION CHANGES IN RAT LIVER: A CROSS-LABORATORY ANALYSIS USING MEMBRANE CDNA ARRAYS |
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Microarrays have the potential to significantly impact our ability to identify toxic hazards by the identification of mechanistically-relevant markers of toxicity. To be useful fo...
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COMPARISON OF COMPARATIVE GENOMIC HYBRIDIZATIONS TECHNOLOGIES ACROSS MICROARRAY PLATFORMS |
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Comparative Genomic Hybridization (CGH) measures DNA copy number differences between a reference genome and a test genome. The DNA samples are differentially labeled and hybridized...
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COMPUTATIONAL TOXICOLOGY: AN APPROACH FOR PRIORITIZING CHEMICAL RISK ASSESSMENTS |
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Characterizing toxic effects for industrial chemicals carries the challenge of focusing resources on the greatest potential risks for human health and the environment. The union of...
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COMPUTATIONAL TOXICOLOGY: FRAMEWORK, PARTNERSHIPS, AND PROGRAM DEVELOPMENT. SEPTEMBER 29-30, 2003, RESEARCH TRIANGLE PARK, NORTH CAROLINA |
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Abstract
The EPA sponsored a workshop held September 29-30, 2003 at the EPA in RTP that was focused on a proposal entitled "A Framework for a Computational Toxicology R...
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COMPUTATIONAL TOXICOLOGY: NEW APPROACHES TO IMPROVE ENVIRONMENTAL HEALTH PROTECTION |
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The mission of the U.S. Environmental Protection Agency is to safeguard public health and the environment from harmful effects that may be caused by exposure to pollutants in the a...
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CONCEPTUAL FRAMEWORK FOR THE CHEMICAL EFFECTS IN BIOLOGICAL SYSTEMS (CEBS) TOXICOGENOMICS KNOWLEDGE BASE |
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Conceptual Framework for the Chemical Effects in Biological Systems (CEBS) T oxicogenomics Knowledge Base
Abstract
Toxicogenomics studies how the genome is involved in ...
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Chapter I. Toxicogenomics in Ecological Risk Assessments: Regulatory Context, Technical Background, and Workshop Overview |
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Development of conceptual framework concerning how genomic data could effectively impact different types of ecological risk assessments in both the short and long term....
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Concordance in Genomic Changes Between Mouse Lungs and Human Airway Epithelial Cells Exposed to Diesel Exhaust Particles |
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Human and animal toxicity studies have shown that exposure to diesel exhaust particles (DEP) or their constituents affect multiple biological processes including immune and inflamm...
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DEFINING THE CHEMICAL SPACE OF PUBLIC GENOMIC DATA (S) |
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The current project aims to chemically index the genomics content of public genomic databases to make these data accessible in relation to other publicly available, chemically-inde...
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DEFINING THE CHEMICAL SPACE OF PUBLIC GENOMIC DATA. |
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The pharmaceutical industry has demonstrated success in integrating of chemogenomic knowledge into predictive toxicological models, due in part to industry's access to large amount...
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DEFINING THE MANDATE OF PROTEOMICS IN THE POST-GENOMIC ERA: WORKSHOP REPORT |
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Research in proteomics is the next step after genomics in understanding life processes at the molecular level. In the largest sense proteomics encompasses knowledge of the structur...
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DEVELOPING COMPUTATIONAL TOOLS NECESSARY FOR APPLYING TOXICOGENOMICS TO RISK ASSESSMENT AND REGULATORY DECISION MAKING. |
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GENOMICS, PROTEOMICS & METABOLOMICS CAN PROVIDE USEFUL WEIGHT-OF-EVIDENCE DATA ALONG THE SOURCE-TO-OUTCOME CONTINUUM, WHEN APPROPRIATE BIOINFORMATIC AND COMPUTATIONAL METHODS ARE A...
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DEVELOPING MECHANISTIC DATA FOR INCORPORATION INTO CANCER AND GENETIC RISK ASSESSMENTS: OLD PROBLEMS AND NEW APPROACHES |
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26th Lauriston S. Taylor Lecture
DEVELOPING MECHANISTIC DATA FOR INCORPORATION INTO CANCER AND
GENETIC RISK ASSESSMENTS: OLD PROBLEMS AND NEW APPROACHES
R. Julian Preston,...
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DEVELOPMENT OF DNA MICROARRAYS FOR ECOLOGICAL EXPOSURE ASSESSMENT |
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EPA/ORD is moving forward with a computational toxicology initiative in FY 04 which aims to integrate genomics and computational methods to provide a mechanistic basis for predicti...
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DIGGING DEEPER INTO DEEP DATA: MOLECULAR DOCKING AS A HYPOTHESIS-DRIVEN BIOPHYSICAL INTERROGATION SYSTEM IN COMPUTATIONAL TOXICOLOGY. |
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Developing and evaluating prediactive strategies to elucidate the mode of biological activity of environmental chemicals is a major objective of the concerted efforts of the US-EPA...
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DISC-BASED IMMUNOASSAY MICROARRAYS. (R825433) |
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Microarray technology as applied to areas that include genomics, diagnostics, environmental, and drug discovery, is an interesting research topic for which different chip-based ...
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DOES RESPONSE EVALUATION OF GENE EXPRESSION PROFILES IN THE SKIN OF K6/ODC MICE EXPOSED TO SODIUM ARSENITE |
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Abstract - Chronic drinking water exposure to inorganic arsenic and its metabolites increases tumor frequency in the skin of K6/ODC transgenic mice. To identify potential biomarke...
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DSSTOX WEBSITE LAUNCH: IMPROVING PUBLIC ACCESS TO DATABASES FOR BUILDING STRUCTURE-TOXICITY PREDICTION MODELS |
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DSSTox Website Launch: Improving Public Access to Databases for Building Structure-Toxicity Prediction Models
Ann M. Richard
US Environmental Protection Agency, Research Tria...
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ECOTOXICOGENOMICS: LINKAGES BETWEEN EXPOSURE AND EFFECTS IN ASSESSING RISKS OF AQUATIC CONTAMINANTS TO FISH |
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Understanding the biological effects of exposures to chemicals in the environment relies on classical and emerging technologies in the areas of genomics, proteomics, and metabonomi...
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ECOTOXICOGENOMICS: LINKAGES BETWEEN EXPOSURE AND EFFECTS IN ASSESSING RISKS OF AQUATIC CONTAMINANTS TO FISH (JOURNAL ARTICLE) |
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Understanding the biological effects of exposures to chemicals in the environment relies on classical methods and emerging technologies in the areas of genomics, proteomics, and me...
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EMERGING MOLECULAR COMPUTATIONAL APPROACHES FOR CROSS-SPECIES EXTRAPOLATIONS: A WORKSHOP SUMMARY |
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Advances in molecular technology have led to the elucidation of full genomic sequences of several multicellular organisms, ranging from nematodes to man. The related molecular fiel...
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EMS POTENTIAL IMPACTS OF GENOMICS ON EPA REGULATORY AND RISK ASSESSMENT APPLICATIONS |
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abstract for oral presentation...
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EPA ACTIVITIES TO PREPARE FOR REGULATORY AND RISK ASSESSMENT APPLICATIONS OF GENOMICS INFORMATION |
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Genomics will have significant implications for risk assessment and regulatory decision making. Since 2002, the U.S. EPA has undertaken a number of cross-Agency activities to furt...
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EPA SCIENCE FORUM - EPA'S TOXICOGENOMICS PARTNERSHIPS ACROSS GOVERNMENT, ACADEMIA AND INDUSTRY |
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Over the past decade genomics, proteomics and metabonomics technologies have transformed the science of toxicology, and concurrent advances in computing and informatics have provid...
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EPA'S TOXCAST PROGRAM FOR PREDICTING HAZARD AND PRIORITIZING TOXICITY TESTING OF ENVIRONMENTAL CHEMICALS |
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EPA is developing methods for utilizing computational chemistry, high-throughput screening (HTS) and various toxicogenomic technologies to predict potential for toxicity and priori...
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EPA'S TOXCAST PROGRAM FOR PREDICTING TOXICITY AND PRIORITIZING ENVIRONMENTAL CHEMICALS |
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ToxCast is a research program to predict or forecast toxicity by evaluating a broad spectrum of chemicals and effects; physical-chemical properties, predicted bioactivities, HTS an...
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EPA'S TOXICOGENOMICS PARTNERSHIPS ACROSS GOVERNMENT, ACADEMIA AND INDUSTRY |
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Genomics, proteomics and metabonomics technologies are transforming the science of toxicology, and concurrent advances in computing and informatics are providing management and ana...
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EPA's ToxCast Program for Predicting Toxicity and Prioritizing Chemical Testing |
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Integrate modern computing and information technology with molecular biology to improve Agency prioritization of data requirements and risk assessment of chemicals...
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EPA's Toxcast ™ Program for Predicting Hazard and Priortizing Toxicity Testing of Environemntal Chemicals (T) |
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EPA is developing methods for utilizing computational chemistry, high-throughput screening (HTS) and various toxicogenomic technologies to predict potential for toxicity and priori...
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EPA’s ToxCast Program for Predicting Hazard and Prioritizing the Toxicity Testing of Environmental Chemicals |
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An alternative is to perform a set of relatively inexpensive and rapid high throughput screening (HTS) assays, derive signatures predictive of effects or modes of chemical toxicity...
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EXPLOITING GENOME DATA TO UNDERSTAND THE FUNCTION, REGULATION AND EVOLUTIONARY ORIGINS OF TOXICOLOGICALLY RELEVANT GENES |
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The wealth of new information coming from the many genome sequencing projects is providing unprecedented opportunities for major advances in all areas of biology, including the env...
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FUNCTIONAL GENOMICS OF PARTICLE-INDUCED LUNG INJURY. (U915732) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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GENE EXPRESSION NETWORKS |
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"Gene expression network" is the term used to describe the interplay, simple or complex, between two or more gene products in performing a specific cellular function. Although the...
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GENE EXPRESSION PROFILES FOR FATHEAD MINNOWS EXPOSED TO ETHINYLESTRADIOL |
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Presentation will provide atate-of-the-art information on results of genomics work with fathead minnows exposed to endocrine-disrupting chemicals...
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GENOMIC ANALYSIS OF SURROGATE TISSUES FOR ASSESSING ENVIRONMENTAL EXPOSURES AND FUTURE DISEASE STATES |
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Genomic Analysis of Surrogate Tissues for Assessing Environmental Exposures and Future Disease States
John C. Rockett, Chad R. Blystone, Amber K. Goetz, Rachel N. Murrell, H...
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GENOMIC AND PROTEOMIC ANALYSIS OF SURROGATE TISSUES FOR ASSESSING TOXIC EXPOSURES AND DISEASE STATES |
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Genomic and Proteomic Analysis of Surrogate Tissues for Assessing Toxic Exposures and Disease States
David J. Dix and John C. Rockett
Reproductive Toxicology Division, Nation...
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GENOMIC AND PROTEOMIC TECHNIQUES APPLIED TO REPRODUCTIVE BIOLOGY |
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Genomic and proteomic techniques applied to reproductive biology
John C. Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laborato...
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GENOMICS AND ENVIRONMENTAL RESEARCH |
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The impact of recently developed and emerging genomics technologies on environmental sciences has significant implications for human and ecological risk assessment issues. The lin...
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GENOMICS IN ECOLOGICAL RISK ASSESSMENT: HOLY GRAIL OR HYPE? |
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This presentation provides an overview of the possible role of genomics tools in ecological risk assessment in the coming 25 years....
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GENOMICS RESEARCH APPLIED TO ISSUES IN ECOLOGICAL RISK ASSESSMENT |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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GENOMICS: CHALLENGES AND OPPORTUNITIES FOR THE U.S. ENVIRONMENTAL PROTECTION AGENCY |
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Genomics information has great potential to enhance assessment of risks to human health and the environment, and consequently, will have significant implications for EPA. Although ...
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Genomics in Regulatory Ecotoxicology: Applications and Challenges |
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This book is the result of a Pellston workshop. The primary goal of the workshop was to develop a conceptual framework concerning how genomic data could effectively impact differe...
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HIGH-THROUGHPUT IDENTIFICATION OF CATALYTIC REDOX-ACTIVE CYSTEINE RESIDUES |
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Cysteine (Cys) residues often play critical roles in proteins; however, identification of their specific functions has been limited to case-by-case experimental approaches. We deve...
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HISTORY OF BIOMONITORING IN THE UNITED STATES - EXTENDED ABSTRACT |
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Biomonitoring of ecological systems has a long history dating back several centuries when high levels of industrial and urban pollution caused discolored rivers, noxious smells, fi...
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HOW CAN BIOLOGICALLY-BASED MODELING OF ARSENIC KINETICS AND DYNAMICS INFORM THE RISK ASSESSMENT PROCESS? |
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Quantitative biologically-based models describing key events in the continuum from arsenic exposure to the development of adverse health effects provide a framework to integrate in...
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IDENTIFICATION OF INTERSPECIES CONCORDANCE OF MECHANISMS OF ARSENIC-INDUCED BLADDER CANCER |
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Exposure to arsenic causes cancer by inducing a variety of responses that affect the expression of genes associated with numerous biological pathways leading to altered cell growth...
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IMMUNOTOXICOGENOMICS: THE POTENTIAL OF GENOMICS TECHNOLOGY IN THE IMMUNOTOXICITY RISK ASSESSMENT PROCESS |
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Evaluation of xenobiotic-induced changes in gene expression as a method to identify and classify potential toxicants is being pursued by industry and regulatory agencies worldwide....
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INTRODUCTION: PREDICTIVE TOXICOGENOMICS AS A COMPONENT OF THE TOXCAST PROGRAM |
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Slide presentation about the NCCT ToxCast Program...
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INVESTIGATIONS INTO MOLECULAR PATHWAYS IN THE POST GENOME ERA: CROSS SPECIES COMPARATIVE GENOMICS APPROACH |
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Genome sequencing efforts in the past decade were aimed at generating draft sequences of many prokaryotic and eukaryotic model organisms. Successful completion of unicellular e...
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IRON STRESS IN ARABIDOPSIS - IS GENOMICS REVEALING? (R827612E02) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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Increased Transcription of Immune and Metabolic Pathways in Naive and Allergic Mice Exposed to Diesel Exhaust |
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Diesel exhaust (DE) has been shown to enhance allergic sensitization in animals following high dose instillation or chronic inhalation exposure scenarios. The purpose of this study...
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Integrating Demographic, Clinical,and Environmental Exposure Information to Identify Genomic Biomarkers Associated With Subtypes of Childhood Asthma |
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Childhood asthma is a multifactorial disease with a disturbingly high incidence in urbanized areas. The pathogenesis of asthma is poorly understood due to the complex relationship ...
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LIPOMICS, AN IMPORTANT COMPONENT OF METABOLOMICS, AND POSSIBLE USE IN TOXICOLOGY STUDIES |
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Metabolites of endogenous biochemical substances can be considered to represent the ultimate organ and cellular responses to toxicants or other changes in an organism's environment...
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Linkage of exposure and effects using genomics, proteomics and metabolomics in small fish models (presentation) |
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This research project combines the use of whole organism endpoints, genomic, proteomic and metabolomic approaches, and computational modeling in a systems biology approach to 1) id...
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MACRORESULTS THROUGH MICROARRAYS |
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The third enactment of Cambridge Healthtech Institute's "Macroresults through Macroarrays" meeting was held in Boston, MA, from April 29th-May 1st, 2002. The subtheme of this year'...
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MEETING IN PORTUGAL: LINKAGE OF EXPOSURE AND EFFECTS USING GENOMICS, PROTEOMICS AND METABOLOMICS IN SMALL FISH MODELS |
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With an interdisciplinary team of scientists from U.S. Government Agencies and Universities, we are utilizing zebrafish and fathead minnow to develop techniques for extrapolation o...
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MEETING REPORT ASSESSING HUMAN GERM-CELL MUTAGENESIS IN THE POST-GENOME ERA: A CELEBRATION OF THE LEGACY OF WILLIAM LAWSON (BILL) RUSSELL |
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Although numerous germ-cell mutagens have been identified in animal model systems, to date, no human germ-cell mutagens have been confirmed. Because the genomic integrity of our g...
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METABOLOMICS AS A DIAGNOSTIC TOOL FOR SMALL FISH TOXICOLOGY RESEARCH |
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Presentation provides state-of-the-art information on results of genomics work with fathead minnows exposed to endocrine-disrupting chemicals...
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MICROARRAY DATA ANALYSIS USING MULTIPLE STATISTICAL MODELS |
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Microarray Data Analysis Using Multiple Statistical Models
Wenjun Bao1, Judith E. Schmid1, Amber K. Goetz1, Ming Ouyang2, William J. Welsh2,Andrew I. Brooks3,4, ChiYi Chu3,M...
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MICROARRAY QUALITY CONTROL PROJECT: A COMPREHENSIVE GENE EXPRESSION TECHNOLOGY SURVEY DEMONSTRATES MEASURABLE CONSISTENCY AND CONCORDANT RESULTS BETWEEN PLATFORMS |
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Microarray technology has had a profound impact on gene expression research. In this report, we detail the experimental design and probe mapping efforts. ...
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MICROBIAL SOURCE TRACKING - 2005 |
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Fecal contamination of surface waters used for recreation, drinking water and aquaculture are a continuous environmental problem and pose significant human health risks. An alarmi...
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NHEERL'S PUBLISHED EPA REPORTS, 2001-2002, TOTAL = 1 (LIST D) |
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This report contains an attachment in Field 14 listing the citations for all EPA Reports (600 series) published by NHEERL during the period June 2001 - May 2002. (The citations in...
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NHEERL'S PUBLISHED EPA REPORTS, 2002-2003, TOTAL = 8 (LIST D) |
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This report contains an attachment in Field 14 listing the citations for all EPA Reports (600 series) published by NHEERL during the period June 2001 - May 2002. (The citations in...
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OMICS DATA IN THE QUALITATIVE AND QUANTITATIVE CHARACTERIZATION OF THE MODE OF ACTION IN SUPPORT OF IRIS ASSESSMENTS |
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Knowledge and information generated using new tools/methods collectively called "Omics" technologies could have a profound effect on qualitative and quantitative characterizations ...
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OVERVIEW OF AN INTERLABORATORY COLLABORATION ON EVALUATING THE EFFECTS OF MODEL HEPATOTOXICANTS ON HEPATIC GENE EXPRESSION |
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Evaluating the Effects of Methapyrilene and Clofibrate on Hepatic Gene Expression: A Collaboration Between Laboratories and a Comparison of Platform and Analytical Approaches
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Overview of ToxCast |
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In 2007, EPA launched ToxCast™ in order to develop a cost-effective approach for prioritizing the toxicity testing of large numbers of chemicals in a short period of time. Using da...
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PARTNERSHIPS TO IMPROVE IMMUNOTOXICITY TESTING |
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Research in ITB is focused on the effects that chemicals/environmental contaminants have on modulation of the immune system. Immune modulation may result in suppressed immune func...
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PHYSIOLOCIGALLY BASED PHARMACOKINETIC (PBPK) MODELING AND MODE OF ACTION IN DOSE-RESPONSE ASSESSMENT |
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PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELING AND MODE OF ACTION IN DOSE-RESPONSE ASSESSMENT. Barton HA. Experimental Toxicology Division, National Health and Environmental...
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POTENTIAL IMPACTS OF GENOMIC ON EPA REGULATORY AND RISK ASSESSMENT APPLICATIONS |
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Advances in molecular technology have led to the elucidation of full genomic sequences of several multicellular organisms, ranging from namatodes to man. The related molecular fie...
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PULMONARY GENE EXPRESSION PROFILES OF SPONTANEOUSLY HYPERTENSIVE RATS EXPOSED TO ENVIRONMENTAL TOBACCO SMOKE (ETS) |
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Global gene expression profile analysis can be utilized to derive molecular footprints to understand biochemical
pathways implicated in the origin and progression of diseas...
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QSAR/VFAR WORKSHOP SUMMARY |
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The overarching goal of this workshop was to evaluate the potential uses of Quantitative Structure-Activity Relationship (QSAR) and Virulence Factor-Activity Relationship (VFAR) to...
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RESEARCH PLAN: EFFECTS OF CHEMICAL HERBICIDES AND GENE FLOW ON NON-TARGET PLANTS |
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This project supports EPA's mission to protect human health and to safeguard the natural environment ? air, water, and land ? upon which life depends. Specifically, we address EPA...
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ROLE OF GENOMICS IN REGULATORY ECOTOXICOLOGY: OVERVIEW OF A PELLSTON WORKSHOP |
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This presentation will provide an overview of a Pellston workshop held in September 2005 concerning the role of genomics data in ecological risk assessments...
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SCIENTIFIC FOUNDATION FOR RISK ASSESSMENTS TO PROTECT NON-TARGET PLANTS FROM HERBICIDES |
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SCIENCE QUESTIONS:
EPA's Office of Pesticides Programs (OPP) requires scientifically credible information and methods to assess health and ecological risks from chemical pes...
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SESSION: EMERGING POLLUTANT ASSESSMENT TECHNIQUES TITLE: BACTERIAL SOURCE TRACKING |
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Fecal contamination of surface waters used for recreation, drinking water and aquaculture are a continuous environmental problem and pose significant human health risks. An alarmi...
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SHAPING OUR ENVIRONMENTAL FUTURE: FORESIGHT IN THE OFFICE OF RESEARCH AND DEVELOPMENT |
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Futures analysis is a structured process that uses a variety of analytical tools to help organizations to better understand, anticipate, and influence the potential events and cond...
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SOURCES OF VARIABILITY IN BASELINE GENE EXPRESSION IN RAT LIVER AND KIDNEY |
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Toxicogenomic studies are typically variable in design, but the impact of variations in study design and conduct on control animal gene expression has not been well characterized. ...
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SOURCES OF VARIATION IN BASELINE GENE EXPRESSION LEVELS FROM TOXICOGENOMIC STUDY CONTROL ANIMALS ACROSS MULTIPLE LABORATORIES |
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Variations in study design are typical for toxicogenomic studies, but their impact on gene expression in control animals has not been well characterized. A dataset of control anima...
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SPECIES DATABASES AND THE BIOINFORMATICS REVOLUTION. |
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Biological databases are having a growth spurt. Much of this results from research in genetics and biodiversity, coupled with fast-paced developments in information technology. The...
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SPLICE VARIANT SPECIFIC UPREGULATIONOF CA+2/CALMODULIN DEPENDENT PROTEIN KINASE 1G BY PYRETHROID INSECTICIDES IN VIVO. |
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Pyrethroid insecticides induce neurotoxicity in mammals by interfering with ion channel function in excitable neuronal membranes. Previous work demonstrated dose-dependent increas...
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STATUS OF ENDOCRINE DISRUPTOR SCREENING AND TESTING ACTIVITIES IN THE US: IMPLEMENTATION OF THE EDSTAC RECOMMENDATIONS |
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The last two decades have witnessed a growing concern for chemicals that have the potential to adversely affect the normal functioning of the endocrine system. In 1996, the US Con...
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STRUCTURE-ACTIVITY RELATIONSHIP STUIDES AND THEIR ROLE IN PREDICTING AND INVESTIGATING CHEMICAL TOXICITY |
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Structure-Activity Relationship Studies and their Role in Predicting and Investigating Chemical Toxicity
Structure-activity relationships (SAR) represent attempts to genera...
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STRUCTURE-GUIDED VIRTUAL HIGH-THROUGHPUT SCREENING PRIORITIZATION MODELS OF ENVIRONMENTAL CHEMICALS ACTING AT NUCLEAR RECEPTORS |
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High-throughput screening (HTS)and applied chemical genomics methods are becoming essential quantitative in vitro components of environmental prioritization schemes....
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SUMMARY OF THE NCEA COLLOQUIUM ON CURRENT USE AND FUTURE NEEDS OF GENOMICS IN ECOLOGICAL AND HUMAN HEALTH RISK ASSESSMENT (FINAL REPORT) |
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A colloquium was held on May 8, 2003, in Alexandria Virginia to bring together EPA risk assessors, scientists, and managers in the Program Offices and Regions, as well as laborator...
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SURROGATE TISSUE ANALYSIS: MONITORING TOXICANT EXPOSURE AND HEALTH STATUS OF INACCESSIBLE TISSUES THROUGH THE ANALYSIS OF ACCESSIBLE TISSUES AND CELLS |
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Surrogate Tissue Analysis: Monitoring Toxicant Exposure And Health Status Of Inaccessible Tissues Through The Analysis Of Accessible Tissues And Cells*
John C. Rockett1, Michael...
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THE FUTURE OF TOXICOGENOMICS |
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Toxicology has classically been seen as the science of poisons. In the modern world, however, it has evolved into a composite of related, but distinct disciplines, which together s...
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THE GOOD, THE BAD AND THE UGLY - DETERMINATION OF BACTERIAL VIRULENCE USING ANIMAL MODELS AND MICROARRAY TECHNOLOGY |
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In its Computational Toxicology Program, EPA/ORD proposes to integrate genomics and computational methods to provide a mechanistic basis for the prediction of toxicity of chemicals...
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THE INFLUENCE OF PARTICULATE AIR POLLUTANTS ON ALLERGIC SENSITIZATION IN ANIMAL MODELS |
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Air pollution has long been associated with detrimental health risks in susceptible populations including asthmatics. Experimental evidence in rodents indicates that inhaled or in...
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THE PATH FROM MOLECULAR INDICATORS OF EXPOSURE TO DESCRIBING DYNAMIC BIOLOGICAL SYSTEMS IN AN AQUATIC ORGANISM: MICROARRAYS AND THE FATHEAD MINNOW |
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The extent to which humans and wildlife are exposed to toxicants is an important focus of environmental research. This work has been directed toward the development of molecular i...
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THE ROLE OF MAMMALIAN DATA IN DETERMINING PHARMACEUTICAL RESPONSES IN AQUATIC ORGANISMS |
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The limitations surrounding application of pharmaceutical data are restricted to extrapolation of the animal and human data across phyla. Experience dictates that mammalian data ar...
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THYROID INSUFFICIENCY AND GENE EXPRESSION IN DEVELOPING RAT BRAIN: A DOSE RESPONSE STUDY. |
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Thyroid Insufficiency and Gene Expression in Developing Rat Brain: A Dose Response Study. JE Royland and ME Gilbert, Neurotox. Div., U.S. EPA, RTP, NC, USA. Endocrine disruption is...
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TIME COURSE OF THE TRANSCRIPTIONAL RESPONSE OF RAT CEREBROCORTICAL TISSUE AFTER ACUTE IN VIVO PYRETHROID EXPOSURE. |
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Pyrethroid insecticides disrupt neuronal function by interfering with the function of voltage-sensitive Na+ channels (VSSCs). Distinct differences in the pharmacological actions o...
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TOXICOGENOMIC STUDY OF TRIAZOLE FUNGICIDES AND PERFLUOROALKYL ACIDS |
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Toxicogenomic analysis of five environmental contaminants was performed to investigate the ability of genomics to categorize chemicals and elucidate mechanisms of toxicity. Three t...
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TOXICOGENOMIC STUDY OF TRIAZOLE FUNGICIDES AND PERFLUOROALKYL ACIDS IN RAT LIVERS ACCURATELY CATEGORIZES CHEMICALS AND IDENTIFIES MECHANISMS OF TOXICITY |
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Toxicogenomic analysis of five environmental contaminants was performed to investigate the ability of genomics to chategorize chemicals and elucidate mechanisms of toxicity. ...
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TRANSFORMATION OF DEVELOPMENTAL NEUROTOXICITY DATA INTO STRUCTURE-SEARCHABLE TOXML DATABASE IN SUPPORT OF STRUCTURE-ACTIVITY RELATIONSHIP (SAR) WORKFLOW. |
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Early hazard identification of new chemicals is often difficult due to lack of data on the novel material for toxicity endpoints, including neurotoxicity. At present, there are no...
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The Analysis of Genomic Dose-Response Data in the EPA ToxCast™ Program |
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The U.S. EPA must assess the potential adverse effects of thousands of chemicals, often with limited toxicity information. Accurate toxicity predictions will help prioritize chemic...
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The need for a paradigm shift in toxicology xx. |
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This manuscript briefly reviews the impact of the NAS report “Toxicity Testing in the 21st Century: A Vision and A Strategy” and it’s potential impact on the field of toxi...
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Thyroid insufficiency in developing rat brain: A genomic analysis. |
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Thyroid Insufficiency in the Developing Rat Brain: A Genomic Analysis. JE Royland and ME Gilbert, Neurotox. Div., U.S. EPA, RTP, NC, USA. Endocrine disruption (ED) is an area of ma...
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ToxCast (TM): A New Paradigm for Predicting Hazard and Prioritizing Toxicity Testing |
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A presentation to discuss the ToxCast project and its possibilities...
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ToxCast: One Step in the NRC Vision of 21st Century Toxicology |
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The international community needs better predictive tools for assessing the hazards and risks of chemicals. It is technically feasible to collect bioactivity data on virtually all...
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ToxCast: One Step in the NRC Vision of 21st Century Toxicology (S) |
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The international community needs better predictive tools for assessing the hazards and risks of chemicals. It is technically feasible to collect bioactivity data on virtually all...
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ToxCast: One Step in the NRC Vision of 21st Century Toxicology (T) |
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The international community needs better predictive tools for assessing the hazards and risks of chemicals. It is technically feasible to collect bioactivity data on virtually all...
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Toxicogenomics in Regulatory Ecotoxicology |
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The potential utility of toxicogenomics in toxicological research and regulatory activities has been the subject of scientific discussions, and as with any new technology, there is...
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US FDA and USA EPA Voluntary Submission of Genomic Data Guidance: Current and Future Use of Genomics in Decision Making |
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Appropriate utilization of data from toxicogenomic studies ins an ongoing concern of the regulated industries and the agencies charged with assessing safety or risk. An area of cur...
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USE OF COMPETITIVE GENOMIC HYBRIDIZATION TO ENRICH FOR GENOME-SPECIFIC DIFFERENCES BETWEEN TWO CLOSELY RELATED HUMAN FECAL INDICATOR BACTERIA |
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Enterococci are frequently used as indicators of fecal pollution in surface waters. To accelerate the identification of Enterococcus faecalis-specific DNA sequences, we e...
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USE OF GENOMIC DATA IN RISK ASSESSMENT |
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Use of Genomic Data in Risk Assessment
John C. Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research an...
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USE OF GENOMIC TECHNOLOGIES AND ISOTONIC DOSE-RESPONSE MODELING IN THE DEVELOPMENT OF A BIOCHEMICAL MARKER OF EFFECT FOR PYRETHROID INSECTICIDE. |
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Pyrethroids are pesticides that disrupt nervous system function by prolongation of sodium currents
through voltage-sensitive sodium channels present in nerve membranes. Pyre...
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USE OF SERIAL ANALYSIS OF GENE EXPRESSION (SAGE) TO STUDY GENETIC RESPONSES TO THE PRESENCE OF THE TNT OR RDX BY ARABIDOPSIS THALIANA |
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Phytoremediation is currently being explored for its potential to clean-up of the large number of military sites that have been contaminated by explosives such as 2,4,6-trinitrotol...
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USING GENOMICS AND PROTEOMICS TO DIAGNOSE EXPOSURE OF AQUATIC ORGANISMS TO ENVIRONMENTAL CONTAMINANTS |
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Advances in molecular biology allow the use of cutting-edge genomic and proteomic tools to assess the effects of environmental contaminants on aquatic organisms. Techniques are ava...
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USING GENOMICS TO EXAMINE ENVIRONMENTAL EXPOSURE IN THE FATHEAD MINNOW |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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USING GENOMICS TO EXAMINE MULTIPLE EXPOSURE VARIABLES IN BIOINDICATORS RESEARCH |
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Genomics technologies provide a powerful tool for rapid assessment of differentially expressed genes in laboratory and field animals exposed to toxicants, and a means by which to l...
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Use Of Genomics In Chemical Mode Of Action Analysis |
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The US-EPA has spent considerable effort in the last few years to develop guidance on the use of genomics to inform the process for determining effects on humans and ecological spe...
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