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Sexually Transmitted Diseases
Sexually Transmitted Diseases  >  Gonorrhea  >  Antibiotic-Resistant Gonorrhea  >  Interpretive Criteria

2002 Interpretive Criteria for Neisseria gonorrhoeae Susceptibility Testing

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The following are zone diameter interpretive standards and equivalent minimal inhibitory concentration (MIC) breakpoints* for Neisseria gonorrhoeae according to the National Committee for Clinical Laboratory Standards (Performance Standards for Antimicrobial Susceptibility Testing; Twelfth International Supplement.  January 2002;  M100-S12, 22 (1): 53-55):

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*At this time, no interpretive criteria exists for Azithromycin and Levofloxacin

Antimicrobial Agent Zone Diameter
(nearest whole mm)		 Equivalent MIC Breakpoints
(µg/mL)
R I S R S
Penicillins
Penicillin <=26 27-46 >=47 >=2 <=0.06
Cephems (Parenteral)
Cefotaxime - - >=31 - <=0.5
Ceftizoxime - - >=38 - <=0.5
Ceftriaxone - -

>=35

 -

<=0.25

Cefmetazole

<=27

28-32

>=33

>=8

<=2
Cefotetan <=19 20-25 >=26 >=8 <=2
Cefoxitin <=23 24-27 >=28 >=8 <=2
Cefuroxime sodium (parenteral) <=25 26-30 >=31 >=4 <=1

Cefepime

-

-

>=31

-

<=0.5

Ceftazidime

-

-

>=31

-

<=0.5

Cephems (Oral)
Cefixime - - >=31 - <=0.25

Cefpodoxime

-

-

>=29

-

<=0.5

Cefetamet

-

-

>=29

-

<=0.5

Tetracyclines

Tetracycline

<=30

31-37

>=38

>=2

<=0.25

Fluoroquinolones

Ciprofloxacin

<=27

28-40

>=41

>=1

<=0.06
Gatifloxacin <=33 34-37 >=38 >=0.5 <=0.12
Ofloxacin <=24 25-30 >=31 >=2 <=0.25

Enoxacin

<=31

32-35

>=36

>=2

<=0.5

Grepafloxacin

<=27

28-36

>=37

>=1

<=0.06

Lomefloxacin

<=26

27-37

>=38

>=2

<=0.12

Trovafloxacin

-

-

>=34

-

<=0.25

Fleroxacin

<=28

29-34

>=35

>=1

<=0.25

Aminocyclitols

Spectinomycin

<=14

15-17

>=18

>=128

<=32
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