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Last Modified: 5/8/2009     First Published: 1/1/1998  
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Phase III Randomized Study of Letrozole Versus Placebo in Postmenopausal Women With Primary Breast Cancer Who Have Completed at Least Five Years of Adjuvant Aromatase Inhibitor

Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Published Results
Related Publications
Trial Contact Information
Registry Information

Alternate Title

Letrozole After Tamoxifen in Treating Women With Breast Cancer

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIITreatmentActivePostmenopausalNCI, Pharmaceutical / IndustryCAN-NCIC-MA17
CALGB-49805, E-JMA17, EORTC-10983, IBCSG-BIG97-01, NCCTG-JMA17, SWOG-JMA17, JRF-Vor-Int-10, NCCTG-CAN-MA17, SWOG-CAN-MA17, NCT00003140, JMA17, MA17

Objectives

Primary

  1. Compare the disease-free survival and overall survival of postmenopausal women with primary breast cancer who have completed at least five years of adjuvant aromatase inhibitor as initial therapy or after tamoxifen treated with letrozole or placebo.

Secondary

  1. Compare the incidence of contralateral breast cancer in patients treated with these regimens.
  2. Evaluate the long-term clinical and laboratory safety of letrozole, in terms of lipid profile, cardiovascular morbidity and mortality, incidence of bone fractures, change in bone density, and common toxic effects, in this patient population.
  3. Compare the quality of life of patients treated with these regimens.

Re-randomization

Primary

  1. Compare disease-free survival of patients who, after receiving at least 4.5 years of letrozole, are re-randomized to receive an additional 5 years of letrozole vs placebo.

Secondary

  1. Determine whether common genetic polymorphisms for genes encoding proteins involved in pharmacokinetic and/or pharmacodynamic pathways for letrozole contribute to individual variation in toxicity and efficacy of letrozole therapy.

Entry Criteria

Disease Characteristics:

  • Histologically or cytologically confirmed primary invasive breast carcinoma resected at time of original diagnosis
    • No ductal carcinoma in situ


  • Axillary lymph node negative, positive, or unknown


  • No evidence of metastases


  • No localized or distant breast cancer recurrence


  • Not registered on protocol NCCTG-893052, any other IBCSG protocol, or protocol SWOG-S9623


  • Hormone receptor status:
    • Estrogen or progesterone receptor positive as defined by tumor receptor content at least 10 fmol/mg protein or receptor positive by ERICA or PgRICA
    • Unknown status allowed if effort to determine status has been made by immunocytochemistry


  • No contralateral breast cancer


Prior/Concurrent Therapy:

Biologic therapy:

  • Not specified

Chemotherapy:

  • Prior adjuvant chemotherapy allowed
  • No concurrent chemotherapy

Endocrine therapy:

  • Completed at least 4.5 but no more than 6 years of adjuvant tamoxifen after resection
  • Completed at least 4.5-6 years of adjuvant aromatase inhibitor as initial therapy or after tamoxifen
  • No more than 3 months since prior adjuvant tamoxifen
  • No concurrent hormone replacement therapy (e.g., megestrol)
  • No concurrent selective estrogen-receptor modulators (e.g., raloxifene or idoxifene)
  • Concurrent intermittent vaginal estrogens (e.g., Estring) allowed if other local measures for intractable vaginal atrophy are insufficient
  • No other concurrent aromatase inhibitors
  • No more than 2 years since prior aromatase inhibitor therapy (re-randomization)

Radiotherapy:

  • Prior radiotherapy allowed

Surgery:

  • See Disease Characteristics

Other:

  • At least 1 month since prior investigational drugs
  • Prior treatment on a clinical trial for breast cancer allowed if permission has been obtained from the sponsors of the original study for their patient to participate on MA.17/JMA.17/BIG-97-01
  • No prior placebo on core protocol
  • No concurrent anticancer therapy
  • Concurrent thyroid medication, calcium, vitamin D, and bisphosphonates allowed

Patient Characteristics:

Age:

  • Postmenopausal

Sex:

  • Female

Menopausal status:

  • Postmenopausal defined by one of the following:
    • Age 50 or over at start of adjuvant tamoxifen
    • Under age 50 and considered postmenopausal by treating physician at start of adjuvant tamoxifen
    • Under age 50 at start of adjuvant tamoxifen and had bilateral oophorectomy (surgical or radiation)
    • Under age 50 and premenopausal at start of adjuvant tamoxifen, but became amenorrheic during tamoxifen and remained amenorrheic for at least 1 year
    • Considered postmenopausal by physician with LH/FSH levels under the treatment center's postmenopausal limits

Performance status:

  • ECOG 0-2

Life expectancy:

  • At least 5 years

Hematopoietic:

  • WBC ≥ 3,000/mm3

    OR

  • Granulocyte count ≥ 1,500/mm3
  • Platelet count ≥ 100,000/mm3

Hepatic:

  • AST and/or ALT < 2 times upper limit of normal (ULN) (unless imaging examinations have ruled out metastatic disease)
  • Alkaline phosphatase < 2 times ULN (unless imaging examinations have ruled out metastatic disease)

Renal:

  • Not specified

Other:

  • No concurrent medical or psychiatric condition that would preclude study participation
  • No other malignancy within the past 5 years except adequately treated superficial squamous cell or basal cell skin cancer or carcinoma in situ of the cervix
  • Able to swallow study drug
  • Adequate oral intake

Expected Enrollment

4700

A total of 4,700 patients will be accrued for this study.

Outcomes

Primary Outcome(s)

Disease-free survival

Outline

This is a randomized, double-blind, placebo-controlled, multicenter study. Patients are stratified according to receptor status (positive vs unknown), lymph node status (negative vs positive vs unknown), prior adjuvant chemotherapy (yes vs no), interval between last dose of aromatase inhibitor therapy and randomization (< 6 months vs 6 months-2 years), and duration of prior tamoxifen use (0 years vs < 2 years vs 2-4.5 years vs > 4.5 years). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive oral letrozole once daily.


  • Arm II: Patients receive oral placebo once daily.


In both arms, treatment continues for 5 years in the absence of disease progression or unacceptable toxicity. Patients in arm II may then be offered oral letrozole once daily for up to 5 years.

Quality of life is assessed at baseline, at 6 months, and then annually for 4.5 years.

  • Double-blind, re-randomization:

    Patients who complete ≥ 4.5 years of letrozole (arm I) and who did not experience recurrent disease or new primary breast cancer, including ductal carcinoma in situ, may participate in the double-blind, placebo-controlled, re-randomization portion of the study. Patients are stratified according to lymph node status at enrollment (negative vs positive vs unknown), prior adjuvant chemotherapy (yes vs no), and interval between last dose of letrozole and re-randomization (<6 months vs 6 months to 2 years). Common genetic single nucleotide polymorphisms for genes encoding proteins involved in pharmacokinetic and/or pharmacodynamic pathways for letrozole are analyzed in order to determine if these single nucleotide polymorphisms contribute to individual variation in toxicity and efficacy of letrozole therapy.

    Quality of life is assessed as during the first randomization.

Patients are followed annually.

Published Results

Goss PE, Ingle JN, Pater JL, et al.: Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen. J Clin Oncol 26 (12): 1948-55, 2008.[PUBMED Abstract]

Ingle JN, Tu D, Pater JL, et al.: Intent-to-treat analysis of the placebo-controlled trial of letrozole for extended adjuvant therapy in early breast cancer: NCIC CTG MA.17. Ann Oncol 19 (5): 877-82, 2008.[PUBMED Abstract]

Muss HB, Tu D, Ingle JN, et al.: Efficacy, toxicity, and quality of life in older women with early-stage breast cancer treated with letrozole or placebo after 5 years of tamoxifen: NCIC CTG intergroup trial MA.17. J Clin Oncol 26 (12): 1956-64, 2008.[PUBMED Abstract]

Chapman JW, Meng D, Shepherd L, et al.: Competing causes of death in breast cancer extended adjuvant endocrine therapy: NCIC CTG MA.17. [Abstract] American Society of Clinical Oncology 2007 Breast Cancer Symposium, 7-8 September 2007, San Francisco, California A-56, 2007.

Goss PE, Ingle JN, Martino S, et al.: Efficacy of letrozole extended adjuvant therapy according to estrogen receptor and progesterone receptor status of the primary tumor: National Cancer Institute of Canada Clinical Trials Group MA.17. J Clin Oncol 25 (15): 2006-11, 2007.[PUBMED Abstract]

Goss P: Breaking the 5-year barrier: results from the MA.17 extended adjuvant trial in women who have completed adjuvant tamoxifen treatment. [Abstract] European Journal of Cancer Supplements 4 (9): 10-5, 2006.

Ingle JN, Tu D, Pater JL, et al.: Duration of letrozole treatment and outcomes in the placebo-controlled NCIC CTG MA.17 extended adjuvant therapy trial. Breast Cancer Res Treat 99 (3): 295-300, 2006.[PUBMED Abstract]

Ingle J, Tu D, Shepherd L, et al.: NCIC CTG MA.17: intent to treat analysis (ITT) of randomized patients after a median follow-up of 54 months. [Abstract] J Clin Oncol 24 (Suppl 18): A-549, 2006.

Moy B, Tu D, Shepherd LE, et al.: NCIC CTG MA.17: tolerability of letrozole among ethnic minority women. [Abstract] J Clin Oncol 24 (Suppl 18): A-6018, 305s, 2006.

Pater JL, Tu D, Ingle JN, et al.: An evaluation of the early termination (ET) of MA.17 extended adjuvant therapy trial. [Abstract] Breast Cancer Res Treat 100 (Suppl 1): A-2081, S107-8, 2006.

Perez EA, Josse RG, Pritchard KI, et al.: Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17. J Clin Oncol 24 (22): 3629-35, 2006.[PUBMED Abstract]

Robert NJ, Goss PE, Ingle JN, et al.: Updated analysis of NCIC CTG MA.17 (letrozole vs. placebo to letrozole vs placebo) post unblinding. [Abstract] J Clin Oncol 24 (Suppl 18): A-550, 2006.

Abetz L, Barghout V, Thomas S, et al.: Letrozole did not worsen quality of life relative to placebo in post-menopausal women with early breast cancer: results from the US subjects of the MA-17 study. [Abstract] Breast Cancer Research and Treatment 94 (Suppl 1): A-2047, 2005.

Goss PE, Ingle JN, Martino S, et al.: Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J Natl Cancer Inst 97 (17): 1262-71, 2005.[PUBMED Abstract]

Goss PE, Ingle JN, Palmer MJ, et al.: Updated analysis of NCIC CTG MA.17 (letrozole vs. placebo to letrozole vs placebo) post unblinding. [Abstract] Breast Cancer Research and Treatment 94 (Suppl 1): A-16, 2005.

Goss PE, Ingle JN, Tu D: NCIC CTG MA17: disease free survival according to estrogen receptor and progesterone receptor status of the primary tumor. [Abstract] Breast Cancer Research and Treatment 94 (Suppl 1): A-2042, 2005.

Ingle JN, Goss PE, Tu D: Analysis of duration of letrozole extended adjuvant therapy as measured by hazard ratios of disease recurrence over time for patients on NCIC CTG MA.17. [Abstract] Breast Cancer Research and Treatment 94 (Suppl 1): A-17, 2005.

Luk C, Goss P, Pritchard K, et al.: Determinants of preferences for starting extended adjuvant letrozole (L) in postmenopausal women following five years of tamoxifen. [Abstract] J Clin Oncol 23 (Suppl 16): A-642, 39s, 2005.

Vachon CM, Ingle JN, Scott CG, et al.: Pilot study of changes in mammographic density in women treated with letrozole or placebo on NCIC CTG MA17. [Abstract] Breast Cancer Research and Treatment 94 (Suppl 1): A-6005, 2005.

Whelan TJ, Goss PE, Ingle JN, et al.: Assessment of quality of life in MA.17: a randomized, placebo-controlled trial of letrozole after 5 years of tamoxifen in postmenopausal women. J Clin Oncol 23 (28): 6931-40, 2005.[PUBMED Abstract]

Goss PE, Ingle JN, Martino S, et al.: Updated analysis of the NCIC CTG MA.17 randomized placebo (P) controlled trial of letrozole (L) after five years of tamoxifen in postmenopausal women with early stage breast cancer. [Abstract] J Clin Oncol 22 (Suppl 14): A-847, 88s, 2004.

Whelan T, Goss P, Ingle J, et al.: Assessment of quality of life (QOL) in MA.17, a randomized placebo-controlled trial of letrozole in postmenopausal women following five years of tamoxifen. [Abstract] J Clin Oncol 22 (Suppl 14): A-517, 7s, 2004.

Goss PE, Ingle JN, Martino S, et al.: A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med 349 (19): 1793-802, 2003.[PUBMED Abstract]

Related Publications

Baum M: Adjuvant endocrine therapy in postmenopausal women with early breast cancer: where are we now? Eur J Cancer 41 (12): 1667-77, 2005.[PUBMED Abstract]

Baum M: Current status of aromatase inhibitors in the management of breast cancer and critique of the NCIC MA-17 trial. Cancer Control 11 (4): 217-21, 2004 Jul-Aug.[PUBMED Abstract]

Booth CM, Pater JL, Goss PE: Identifying breast cancer patients most likely to benefit from aromatase inhibitor therapy after adjuvant tamoxifen. Cancer 109 (9): 1927-8; author reply 1928, 2007.[PUBMED Abstract]

Buzdar A, Chlebowski R, Cuzick J, et al.: Defining the role of aromatase inhibitors in the adjuvant endocrine treatment of early breast cancer. Curr Med Res Opin 22 (8): 1575-85, 2006.[PUBMED Abstract]

Scott LJ, Keam SJ: Letrozole : in postmenopausal hormone-responsive early-stage breast cancer. Drugs 66 (3): 353-62, 2006.[PUBMED Abstract]

Vakaet L: Re: Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J Natl Cancer Inst 98 (16): 1162; author reply 1162-3, 2006.[PUBMED Abstract]

Wardley AM: Emerging data on optimal adjuvant endocrine therapy: Breast International Group trial 1-98/MA.17. Clin Breast Cancer 6 (Suppl 2): S45-50, 2006.[PUBMED Abstract]

Trial Contact Information

Trial Lead Organizations

NCIC-Clinical Trials Group

Paul Goss, MD, PhD, Protocol chair
Ph: 617-724-3118; 877-726-5130

North Central Cancer Treatment Group

James Ingle, MD, Protocol chair
Ph: 507-284-3731
Email: ingle.james@mayo.edu

International Breast Cancer Study Group

Monica Castiglione-Gertsch, MD, Protocol chair(Contact information may not be current)
Ph: 41-31-632-2243

Eastern Cooperative Oncology Group

Nicholas Robert, MD, Protocol chair
Ph: 703-280-5390
Email: nicholas.robert@usoncology.com

Southwest Oncology Group

Silvana Martino, DO, Protocol chair
Ph: 310-582-7900
Email: martinos@jwci.org

Cancer and Leukemia Group B

Hyman Muss, MD, Protocol chair
Ph: 802-847-3827

European Organization for Research and Treatment of Cancer

Martine Piccart-Gebhart, MD, PhD, Protocol chair
Ph: 32-2-541-3206
Email: martine.piccart@bordet.be

Trial Sites

U.S.A.
Alabama
  Birmingham
 Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham
 Clinical Trials Office - Lurleen Wallace Comprehensive Cancer
Ph: 205-934-0309
Arizona
  Phoenix
 Banner Good Samaritan Medical Center
 Lawrence Kasper, MD
Ph: 602-258-4875
 CCOP - Western Regional, Arizona
 Lawrence Kasper, MD
Ph: 602-258-4875
  Scottsdale
 Mayo Clinic Scottsdale
 Clinical Trials Office - All Mayo Clinic Locations
Ph: 507-538-7623
  Tucson
 Arizona Cancer Center at University of Arizona Health Sciences Center
 Clinical Trials Office - Arizona Cancer Center at University of Arizona Health Sciences Center
Ph: 520-626-9008
Arkansas
  Bentonville
 Highlands Oncology Group - Springdale
 Joseph Beck, MD, FACP
Ph: 479-587-1700
  Ft. Smith
 Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
 John Wells, MD
Ph: 479-484-4700
California
  Berkeley
 Alta Bates Summit Comprehensive Cancer Center
 Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center
Ph: 510-204-3428
  Burlingame
 Peninsula Medical Center
 David Irwin, MD
Ph: 510-204-1591
  Castro Valley
 East Bay Radiation Oncology Center
 James Feusner, MD
Ph: 510-428-3689
 Eden Medical Center
 James Feusner, MD
Ph: 510-428-3689
 Valley Medical Oncology Consultants - Castro Valley
 James Feusner, MD
Ph: 510-428-3689
  Concord
 Cancer Care Center at John Muir Health - Concord Campus
 Clinical Trials Office - Cancer Care Center at John Muir Health - Concord Campus
Ph: 925-674-2580
  Fairfield
 North Bay Cancer Center
 Clinical Trials Office - North Bay Cancer Center
Ph: 707-429-6976
  Fremont
 Valley Medical Oncology
 James Feusner, MD
Ph: 510-428-3689
  Greenbrae
 Marin Cancer Institute at Marin General Hospital
 David Irwin, MD
Ph: 510-204-1591
 Sutter Health - Western Division Cancer Research Group
 David Irwin, MD
Ph: 510-204-1591
  Loma Linda
 Loma Linda University Cancer Institute at Loma Linda University Medical Center
 Clinical Trials Office - Loma Linda University Cancer Institute
Ph: 909-558-3375
  Los Angeles
 USC/Norris Comprehensive Cancer Center and Hospital
 Clinical Trials Office - USC/Norris Comprehensive Cancer Center and Hospital
Ph: 323-865-0451
  Monterey
 Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
 John Hausdorff, MD, FACP
Ph: 831-375-4105
  Oakland
 Alta Bates Summit Medical Center - Summit Campus
 Clinical Trials Office - Alta Bates Summit Medical Center - Summit Campus
Ph: 510-204-1414
 Bay Area Breast Surgeons, Incorporated
 James Feusner, MD
Ph: 510-428-3689
 CCOP - Bay Area Tumor Institute
 James Feusner, MD
Ph: 510-428-3689
 Highland General Hospital
 James Feusner, MD
Ph: 510-428-3689
 Larry G Strieff MD Medical Corporation
 James Feusner, MD
Ph: 510-428-3689
 Tom K Lee, Incorporated
 James Feusner, MD
Ph: 510-428-3689
  Pasadena
 Huntington Cancer Center at Huntington Hospital
 Clinical Trials Office - Huntington Cancer Center
Ph: 626-535-2420
  Pleasanton
 Valley Care Medical Center
 James Feusner, MD
Ph: 510-428-3689
 Valley Medical Oncology Consultants - Pleasanton
 James Feusner, MD
Ph: 510-428-3689
  San Diego
 Kaiser Permanente Medical Office -Vandever Medical Office
 Han Koh
Ph: 619-528-2596
 Naval Medical Center - San Diego
 Preston Gable, MD, FACP
Ph: 619-532-7319
  San Francisco
 California Pacific Medical Center - California Campus
 David Irwin, MD
Ph: 510-204-1591
 UCSF Helen Diller Family Comprehensive Cancer Center
 Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center
Ph: 877-827-3222
  San Pablo
 Doctors Medical Center - San Pablo Campus
 James Feusner, MD
Ph: 510-428-3689
  Sana Rosa
 CCOP - Santa Rosa Memorial Hospital
 Ian Anderson, MD
Ph: 707-521-3830
  Vallejo
 Sutter Solano Medical Center
 David Irwin, MD
Ph: 510-204-1591
  Walnut Creek
 John Muir/Mt. Diablo Comprehensive Cancer Center
 Clinical Trials Office - John Muir/Mt. Diablo Comprehensive Cancer Center
Ph: 925-941-4246
Colorado
  Fort Collins
 Poudre Valley Hospital
 Clinical Trials Office - Poudre Valley Hospital
Ph: 970-495-8226
  Greeley
 North Colorado Medical Center
 Lawrence Kasper, MD
Ph: 602-258-4875
  Loveland
 McKee Medical Center
 Lawrence Kasper, MD
Ph: 602-258-4875
Connecticut
  Farmington
 Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
 Clinical Trials Office - Carole and Ray Neag Comprehensive Cancer Center
Ph: 800-579-7822
  Hartford
 Helen and Harry Gray Cancer Center at Hartford Hospital
 Clinical Trials Office - Helen and Harry Gray Cancer Center
Ph: 860-545-5363
  Manchester
 Manchester Memorial Hospital
 Jeffrey Wasser, MD
Ph: 860-533-4000
  Middletown
 Middlesex Hospital Cancer Center
 Mark Kimmel, MD
Ph: 860-358-2220
  New Britain
 George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
 Clinical Trials Office - George Bray Cancer Center
Ph: 860-224-5660
  New Haven
 Yale Cancer Center
 Clinical Trials Office - Yale Cancer Center
Ph: 203-785-5702
  Stamford
 Carl and Dorothy Bennett Cancer Center at Stamford Hospital
 Clinical Trials Office - Carl and Dorothy Bennett Cancer Center
Ph: 203-323-8944
  Torrington
 Connecticut Oncology & Hematology - Torrington
 Michael Magnifico, MD
Ph: 860-482-5384
Delaware
  Lewes
 Tunnell Cancer Center at Beebe Medical Center
 Clinical Trials Office - Tunnell Cancer Center
Ph: 302-645-3171
  Newark
 CCOP - Christiana Care Health Services
 Clinical Trial Office - CCOP - Christiana Care Health Services
Ph: 302-733-6227
District of Columbia
  Washington
 Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
 Clinical Trials Office - Lombardi Comprehensive Cancer Center
Ph: 202-444-0381
 Walter Reed Army Medical Center
 Clinical Trials Office - Walter Reed Army Medical Center
Ph: 202-782-7840
Florida
  Boca Raton
 Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
 Clinical Trials Office - Eugene M. and Christine E. Lynn Cancer Institute
Ph: 561-955-4800
  Hollywood
 Memorial Cancer Institute at Memorial Regional Hospital
 Clinical Trials Office - Memorial Cancer Institute
Ph: 954-985-3443
  Jacksonville
 Mayo Clinic - Jacksonville
 Clinical Trials Office - All Mayo Clinic Locations
Ph: 507-538-7623
 St. Vincent's Medical Center
 Joel Stone, MD, FACP
Ph: 904-388-2619
  Orlando
 M.D. Anderson Cancer Center at Orlando
 Omar Kayaleh, MD
Ph: 407-648-3800
  Pensacola
 Sacred Heart Cancer Center at Sacred Heart Hospital
 Clinical Trials Office - Sacred Heart Cancer Center
Ph: 850-416-4611
 West Florida Cancer Institute at West Florida Hospital - Pensacola
 Ranjith Dissanayake
Ph: 850-474-8382
  Sarasota
 Florida Cancer Specialists - Sarasota Downtown
 Clinical Trials Office - Florida Cancer Specialists - Sarasota Downtown
Ph: 941-957-1000 ext. 213
Georgia
  Atlanta
 CCOP - Atlanta Regional
 Thomas Seay, MD, PhD
Ph: 404-851-2340
 Northside Hospital Cancer Center
 Clinical Trials Office - Northside Hospital Cancer Center
Ph: 404-303-3355
 Piedmont Hospital
 Thomas Seay, MD, PhD
Ph: 404-851-2340
 Saint Joseph's Hospital of Atlanta
 Clinical Trials Office - Saint Joseph's Hospital of Atlanta
Ph: 404-851-7115
  Austell
 WellStar Cobb Hospital
 Clinical Trials Office - WellStar Cobb Hospital
Ph: 770-793-5980
  Decatur
 Charles B. Eberhart Cancer Center at DeKalb Medical Center
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Lawrenceville
 Gwinnett Medical Center
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Macon
 Medical Center of Central Georgia
 Frederick Schnell, MD, FACP
Ph: 478-743-7068
  Marietta
 Kennestone Cancer Center at Wellstar Kennestone Hospital
 Clinical Trials Office - Kennestone Cancer Center
Ph: 770-793-5980
  Riverdale
 Southern Regional Medical Center
 Clinical Trials Office - Southern Regional Medical Center
Ph: 770-991-8611
  Valdosta
 Pearlman Comprehensive Cancer Center at South Georgia Medical Center
 Jeffrey Hoy, MD
Ph: 229-259-4628
Idaho
  Boise
 Mountain States Tumor Institute at St. Luke's Regional Medical Center
 Thomas Beck, MD
Ph: 208-381-2711
Illinois
  Alton
 Saint Anthony's Hospital at Saint Anthony's Health Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Aurora
 Rush-Copley Cancer Care Center
 Kendrith Rowland, MD
Ph: 217-383-3019
  Chicago
 University of Chicago Cancer Research Center
 Clinical Trials Office - University of Chicago Cancer Research Center
Ph: 773-834-7424
  Decatur
 Decatur Memorial Hospital Cancer Care Institute
 Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute
Ph: 217-876-6601
  Evanston
 Evanston Northwestern Healthcare - Evanston Hospital
 Clinical Trials Office - Evanston Northwestern Healthcare - Evanston Hospital
Ph: 847-570-1381
  Harvey
 Ingalls Cancer Care Center at Ingalls Memorial Hospital
 Clinical Trials Office - Ingalls Cancer Care Center at Ingalls Memorial Hospital
Ph: 708-915-6747
  Hinsdale
 Hinsdale Hematology Oncology Associates
 Elyse Schneiderman, MD
Ph: 630-654-1790
  Joliet
 Joliet Oncology-Hematology Associates, Limited - West
 Kendrith Rowland, MD
Ph: 217-383-3019
  Maywood
 Cardinal Bernardin Cancer Center at Loyola University Medical Center
 Clinical Trials Office - Cardinal Bernardin Cancer Center
Ph: 708-226-4357
  Mt. Vernon
 Good Samaritan Regional Health Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Naperville
 Edward Hospital Cancer Center
 Clinical Trials Office - Edward Hospital Cancer Center
Ph: 630-646-6075
  Normal
 Mid-Illinois Hematology-Oncology Associates at Community Cancer Center
 Hwan Jeong, MD
Ph: 309-452-9701
  Park Ridge
 Advocate Lutheran General Cancer Care Center
 Clinical Trials Office - Advocate Lutheran General Cancer Care Center
Ph: 847-384-3621
  Rockford
 Center for Cancer Care at OSF Saint Anthony Medical Center
 Clinical Trials Office - Center for Cancer Care at OSF Saint Anthony Medical Center
Ph: 815-227-2633
 Swedish-American Regional Cancer Center
 Clinical Trials Office - Swedish-American Regional Cancer Center
Ph: 815-489-4413
  Springfield
 Regional Cancer Center at Memorial Medical Center
 Clinical Trials Office - Regional Cancer Center at Memorial Medical Center
Ph: 217-788-4233
  Urbana
 Carle Cancer Center at Carle Foundation Hospital
 Clinical Trials Office - Carle Cancer Center
Ph: 800-446-5532
 CCOP - Carle Cancer Center
 Clinical Trials Office - CCOP - Carle Cancer Center
Ph: 800-446-5532
Indiana
  Beech Grove
 St. Francis Hospital and Health Centers - Beech Grove Campus
 Howard Gross, MD
Ph: 937-832-1093
  Elkhart
 Elkhart General Hospital
 Rafat Ansari, MD, FACP
Ph: 574-234-5123
  Indianapolis
 Indiana University Melvin and Bren Simon Cancer Center
 Clinical Trials Office - Indiana University Cancer Center
Ph: 317-274-2552
 Methodist Cancer Center at Methodist Hospital
 William Dugan, MD, FACP
Ph: 317-924-4022
 William N. Wishard Memorial Hospital
 Kathy Miller, MD
Ph: 317-274-1690
  Kokomo
 Howard Community Hospital
 Rafat Ansari, MD, FACP
Ph: 574-234-5123
  La Porte
 Center for Cancer Therapy at LaPorte Hospital and Health Services
 Rafat Ansari, MD, FACP
Ph: 574-234-5123
  Michigan City
 Saint Anthony Memorial Health Centers
 Kendrith Rowland, MD
Ph: 217-383-3019
  Richmond
 Reid Hospital & Health Care Services
 Howard Gross, MD
Ph: 937-832-1093
  South Bend
 CCOP - Northern Indiana CR Consortium
 Rafat Ansari, MD, FACP
Ph: 574-234-5123
 Memorial Hospital of South Bend
 Clinical Trials Office - Memorial Hospital of South Bend
Ph: 800-284-7370
 Saint Joseph Regional Medical Center
 Rafat Ansari, MD, FACP
Ph: 574-234-5123
 South Bend Clinic
 Rafat Ansari, MD, FACP
Ph: 574-234-5123
Iowa
  Des Moines
 CCOP - Iowa Oncology Research Association
 Roscoe Morton, MD, FACP
Ph: 515-282-2921
 John Stoddard Cancer Center at Iowa Lutheran Hospital
 Clinical Trials Office - John Stoddard Cancer Center at Iowa Lutheran Hospital
Ph: 515-241-8704
 John Stoddard Cancer Center at Iowa Methodist Medical Center
 Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center
Ph: 515-241-6727
 Medical Oncology and Hematology Associates at John Stoddard Cancer Center
 Roscoe Morton, MD, FACP
Ph: 515-282-2921
 Medical Oncology and Hematology Associates at Mercy Cancer Center
 Roscoe Morton, MD, FACP
Ph: 515-282-2921
 Mercy Cancer Center at Mercy Medical Center - Des Moines
 Roscoe Morton, MD, FACP
Ph: 515-282-2921
 Mercy Capitol Hospital
 Roscoe Morton, MD, FACP
Ph: 515-282-2921
  Iowa City
 Holden Comprehensive Cancer Center at University of Iowa
 Cancer Information Service
Ph: 800-237-1225
  Mason City
 Mercy Cancer Center at Mercy Medical Center - North Iowa
 Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa
Ph: 641-422-6304
  Ottumwa
 McCreery Cancer Center at Ottumwa Regional
 Roscoe Morton, MD, FACP
Ph: 515-282-2921
  Sioux City
 Mercy Medical Center - Sioux City
 Donald Wender, MD, PhD
Ph: 712-252-0088
 Siouxland Hematology-Oncology Associates, LLP
 Donald Wender, MD, PhD
Ph: 712-252-0088
 St. Luke's Regional Medical Center
 Donald Wender, MD, PhD
Ph: 712-252-0088
  Waterloo
 Cedar Valley Medical Specialists, PC - West Ridgeway Avenue
 Boriana Kamenova
Ph: 319-833-5907
 Covenant Cancer Treatment Center
 Clinical Trials Office - Covenant Cancer Treatment Center
Ph: 319-272-2070
Kansas
  Chanute
 Cancer Center of Kansas, PA - Chanute
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Dodge City
 Cancer Center of Kansas, PA - Dodge City
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  El Dorado
 Cancer Center of Kansas, PA - El Dorado
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Independence
 Cancer Center of Kansas-Independence
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Kingman
 Cancer Center of Kansas, PA - Kingman
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Lawrence
 Lawrence Memorial Hospital
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Liberal
 Southwest Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Newton
 Cancer Center of Kansas, PA - Newton
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Overland Park
 Menorah Medical Center
 Rakesh Gaur, MD
Ph: 816-823-0555
  Parsons
 Cancer Center of Kansas, PA - Parsons
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Pratt
 Cancer Center of Kansas, PA - Pratt
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Salina
 Cancer Center of Kansas, PA - Salina
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Shawnee Mission
 Shawnee Mission Medical Center
 Rakesh Gaur, MD
Ph: 816-823-0555
  Topeka
 Cotton-O'Neil Cancer Center
 Clinical Trials Office - Cotton-O'Neil Cancer Center
Ph: 785-270-4963
  Wellington
 Cancer Center of Kansas, PA - Wellington
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Wichita
 Associates in Womens Health, PA - North Review
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Cancer Center of Kansas, PA - Wichita
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Cancer Center of Kansas, PA - Medical Arts Tower
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 CCOP - Wichita
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Wesley Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Winfield
 Cancer Center of Kansas, PA - Winfield
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
Kentucky
  Ashland
 Cancer Care at Our Lady of Bellefonte Hospital
 Clinical Trials Office - Cancer Care at Our Lady of Bellefonte Hospital
Ph: 606-833-3253
  Lexington
 Central Baptist Hospital
 Clinical Trials Office - Central Baptist Hospital
Ph: 859-260-6425
Louisiana
  Alexandria
 Tulane Cancer Center Office of Clinical Research
 Clinical Trials Office - Tulane Cancer Center
Ph: 504-988-6121
  Monroe
 Louisiana State University Health Sciences Center - Monroe
 Glenn Mills, MD
Ph: 318-813-1440
  New Orleans
 CCOP - Ochsner
 Jyotsna Fuloria
Ph: 504-842-3910
 Ochsner Cancer Institute at Ochsner Clinic Foundation
 Jyotsna Fuloria
Ph: 504-842-4360
888-624-7637
  Shreveport
 Feist-Weiller Cancer Center at Louisiana State University Health Sciences
 Clinical Trials Office - Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Ph: 318-813-1412
Maine
  Scarborough
 Maine Center for Cancer Medicine and Blood Disorders - Scarborough
 Tracey Weisberg, MD
Ph: 207-885-7634
Maryland
  Annapolis
 DeCesaris Cancer Institute at Anne Arundel Medical Center
 Stanley Watkins, MD
Ph: 443-481-1000
  Baltimore
 Greenebaum Cancer Center at University of Maryland Medical Center
 Clinical Trials Office - Greenebaum Cancer Center at University of Maryladn Medical Center
Ph: 800-888-8823
 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 Clinical Trials Office - Sidney Kimmel Comprehensive Cancer Center at John Hopkins
Ph: 410-955-8804
 Email: jhcccro@jhmi.edu
  Bethesda
 Suburban Hospital
 G. Pushkas
Ph: 301-896-3021
  Elkton MD
 Union Hospital Cancer Program at Union Hospital
 Stephen Grubbs, MD
Ph: 302-366-1200
  Towson
 Cancer Institute at St. Joseph Medical Center
 Paul Chang, MD
Ph: 410-494-9099
Massachusetts
  Boston
 Beth Israel Deaconess Medical Center
 Clinical Trials Office - Beth Israel Deaconess Medical Center
Ph: 617-667-9925
 Dana-Farber/Brigham and Women's Cancer Center
 Clinical Trials Office
Ph: 617-724-5200
 Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
 Leroy Parker, MD
Ph: 617-632-3427
 Massachusetts General Hospital
 Clinical Trials Office - Massachusetts General Hospital
Ph: 877-726-5130
 Tufts-NEMC Cancer Center
 Kathy Theall, MD
Ph: 617-636-2520
  Brighton
 Caritas St. Elizabeth's Medical Center
 Leslie Martin, MD
Ph: 617-789-2903
  Burlington
 Lahey Clinic Medical Center - Burlington
 Clinical Trials Office - Lahey Clinic Medical Center - Burlington
Ph: 781-744-8027
  Fall River
 Hudner Oncology Center at Saint Anne's Hospital - Fall River
 Clinical Trials Office - Hudner Oncology Center at Saint Anne's Hospital - Fall River
Ph: 508-674-5600 ext. 2019
  Gloucester
 Addison Gilbert Hospital
 Angus McIntyre, MD
Ph: 978-927-6850
  Springfield
 Baystate Regional Cancer Program at D'Amour Center for Cancer Care
 John McCann, MD
Ph: 413-794-3316
  Taunton
 Morton Hospital & Medical Center
 Robert McNamee, MD
Ph: 508-824-5865
  Worcester
 Commonwealth Hematology-Oncology, PC - Worcester
 Marc Ernstoff, MD
Ph: 603-650-5534
 UMASS Memorial Cancer Center - University Campus
 Kathryn Edmiston, MD
Ph: 508-334-5141
Michigan
  Adrian
 Hickman Cancer Center at Bixby Medical Center
 Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center
Ph: 517-265-0116
  Ann Arbor
 CCOP - Michigan Cancer Research Consortium
 Philip Stella, MD
Ph: 734-712-1000
 Saint Joseph Mercy Cancer Center
 Philip Stella, MD
Ph: 734-712-1000
 University of Michigan Comprehensive Cancer Center
 Clinical Trials Office - University of Michigan Comprehensive Cancer Center
Ph: 800-865-1125
  Battle Creek
 Battle Creek Health System Cancer Care Center
 Martin Bury
Ph: 616-966-8000
  Bay City
 Bay Regional Medical Center
 Clinical Trials Office - Bay Regional Medical Center
Ph: 989-667-6257
  Big Rapids
 Mecosta County Medical Center
 Martin Bury
Ph: 231-796-8691
  Dearborn
 Oakwood Cancer Center at Oakwood Hospital and Medical Center
 Clinical Trials Office - Oakwood Cancer Center at Oakwood Hospital and Medical Center
Ph: 313-593-8090
  Detroit
 Barbara Ann Karmanos Cancer Institute
 Clinical Trials Office - Barbara Ann Karmanos Cancer Institute
Ph: 313-576-9363
 Josephine Ford Cancer Center at Henry Ford Hospital
 Robert Chapman, MD
Ph: 313-916-1332
  Flint
 Genesys Hurley Cancer Institute
 Clinical Trials Office - Genesys Hurley Cancer Institute
Ph: 810-762-8057
 Hurley Medical Center
 Clinical Trials Office - Hurley Medical Center
Ph: 810-762-8057
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Martin Bury
Ph: 616-391-2799
 CCOP - Grand Rapids
 Martin Bury
Ph: 616-391-1230
 Lacks Cancer Center at Saint Mary's Health Care
 Martin Bury
Ph: 616-752-5222
  Grosse Pointe Woods
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center
Ph: 313-343-3166
  Jackson
 Foote Memorial Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Kalamazoo
 Borgess Medical Center
 Raymond Lord, MD
Ph: 269-373-7458
 Bronson Methodist Hospital
 Raymond Lord, MD
Ph: 269-373-7458
 West Michigan Cancer Center
 Clinical Trials Office - West Michigan Cancer Center
Ph: 269-373-7458
  Lambertville
 Haematology-Oncology Associates of Ohio and Michigan, PC
 Paul Schaefer, MD
Ph: 419-479-5605
  Lansing
 Sparrow Regional Cancer Center
 Clinical Trials Office - Sparrow Regional Cancer Center
Ph: 517-364-2890
  Livonia
 St. Mary Mercy Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Monroe
 Community Cancer Center of Monroe
 Paul Schaefer, MD
Ph: 419-479-5605
 Mercy Memorial Hospital - Monroe
 Paul Schaefer, MD
Ph: 419-479-5605
  Mount Clemens
 Ted B. Wahby Cancer Center at Mount Clemens General Hospital
 Clinical Trials Office - Ted B. Wahby Cancer Center at Mount Clemens General Hospital
Ph: 586-493-3426
  Muskegon
 Mercy General Health Partners
 Martin Bury
Ph: 231-672-2000
  Petoskey
 Northern Michigan Hospital
 Edward Smith
Ph: 231-487-4000
800-248-6777
  Pontiac
 St. Joseph Mercy Oakland
 Philip Stella, MD
Ph: 734-712-1000
  Port Huron
 Mercy Regional Cancer Center at Mercy Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Saginaw
 Seton Cancer Institute at Saint Mary's - Saginaw
 Clinical Trials Office - Seton Cancer Institute - Saginaw
Ph: 989-776-8411
  Saint Joseph
 Oncology Care Associates, PLLC
 Eric Lester, MD
Ph: 269-985-0029
  St. Joseph
 Lakeland Regional Cancer Care Center - St. Joseph
 Rafat Ansari, MD, FACP
Ph: 574-234-5123
  Traverse City
 Munson Medical Center
 Martin Bury
Ph: 231-935-6202
  Warren
 St. John Macomb Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Wyoming
 Metro Health Hospital
 Martin Bury
Ph: 616-252-7200
Minnesota
  Alexandria
 Harold Windschitl, MD
Ph: 320-229-4907
  Bemidji
 MeritCare Bemidji
 Preston Steen, MD
Ph: 701-234-2397
  Duluth
 CCOP - Duluth
 Daniel Nikcevich, MD, PhD
Ph: 218-786-3625
 Duluth Clinic Cancer Center - Duluth
 Clinical Trials Office - Duluth Clinic Cancer Center - Duluth
Ph: 218-786-3308
 Miller - Dwan Medical Center
 Daniel Nikcevich, MD, PhD
Ph: 218-786-3625
  Fergus Falls
 Harold Windschitl, MD
Ph: 320-229-4907
  Hutchinson
 Hutchinson Area Health Care
 Daniel Anderson
Ph: 320-234-5000
800-454-3903
  Lichfield
 Meeker County Memorial Hospital
 Clinical Trials Office - Meeker County Memorial Hospital
Ph: 320-693-4520
  Maplewood
 HealthEast Cancer Care at St. John's Hospital
 Daniel Anderson
Ph: 651-232-7970
  Minneapolis
 Hennepin County Medical Center - Minneapolis
 Clinical Trials Office - Hennepin County Medical Center - Minneapolis
Ph: 612-873-5911
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Clinical Trials Office - Virginia Piper Cancer Institute
Ph: 612-863-5654
  Rochester
 Mayo Clinic Cancer Center
 Clinical Trials Office - All Mayo Clinic Locations
Ph: 507-538-7623
  Saint Cloud
 CentraCare Clinic - River Campus
 Harold Windschitl, MD
Ph: 320-229-4907
 Coborn Cancer Center
 Harold Windschitl, MD
Ph: 320-229-4907
  Shakopee
 St. Francis Cancer Center at St. Francis Medical Center
 Daniel Anderson
Ph: 952-403-2031
  St. Paul
 Regions Hospital Cancer Care Center
 Clinical Trials Office - Regions Hospital Cancer Care Center
Ph: 651-254-1517
Mississippi
  Kessler AFB
 Keesler Air Force Base Medical Center
 Louis Varner
Ph: 228-377-2086
Missouri
  Cape Girardeau
 Saint Francis Medical Center
 Bethany Sleckman, MD
Ph: 314-251-7057
 Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
 Bethany Sleckman, MD
Ph: 314-251-7057
  Columbia
 Missouri Cancer Associates
 Clinical Trials Office - Missouri Cancer Associates
Ph: 866-724-2413
 Email: research@missouricancer.com
  Independence
 Independence Regional Health Center
 Rakesh Gaur, MD
Ph: 816-823-0555
  Kansas City
 CCOP - Kansas City
 Rakesh Gaur, MD
Ph: 816-823-0555
 North Kansas City Hospital
 Rakesh Gaur, MD
Ph: 816-823-0555
 Parvin Radiation Oncology
 Rakesh Gaur, MD
Ph: 816-823-0555
 Research Medical Center
 Rakesh Gaur, MD
Ph: 816-823-0555
 Saint Luke's Cancer Institute at Saint Luke's Hospital
 Rakesh Gaur, MD
Ph: 816-823-0555
 St. Joseph Medical Center
 Rakesh Gaur, MD
Ph: 816-823-0555
 Truman Medical Center - Hospital Hill
 Rakesh Gaur, MD
Ph: 816-823-0555
  Liberty
 Liberty Hospital
 Rakesh Gaur, MD
Ph: 816-823-0555
  Saint Joseph
 Heartland Regional Medical Center
 Rakesh Gaur, MD
Ph: 816-823-0555
  Saint Louis
 Arch Medical Services, Incorporated at Center for Cancer Care and Research
 Alan Lyss, MD
Ph: 314-996-5514
 CCOP - St. Louis-Cape Girardeau
 Bethany Sleckman, MD
Ph: 314-251-7057
 David C. Pratt Cancer Center at St. John's Mercy
 Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy
Ph: 314-251-6770
 Midwest Hematology Oncology Group, Incorporated
 Bethany Sleckman, MD
Ph: 314-251-7057
 Missouri Baptist Cancer Center
 Alan Lyss, MD
Ph: 314-996-5514
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Michael Naughton, MD
Ph: 314-996-8872
  Springfield
 CCOP - Cancer Research for the Ozarks
 Robert Carolla
Ph: 417-269-4520
 Hulston Cancer Center at Cox Medical Center South
 Robert Carolla
Ph: 417-269-5257
 St. John's Regional Health Center
 Robert Carolla
Ph: 417-820-2000
Montana
  Billings
 Billings Clinic - Downtown
 Clinical Trials Office - Billings Clinic - Downtown
Ph: 800-996-2663
 Email: research@billingsclinic.org
 CCOP - Montana Cancer Consortium
 Benjamin Marchello, MD
Ph: 406-238-6290
 Hematology-Oncology Centers of the Northern Rockies - Billings
 Benjamin Marchello, MD
Ph: 406-238-6290
 Northern Rockies Radiation Oncology Center
 Benjamin Marchello, MD
Ph: 406-238-6290
 St. Vincent Healthcare Cancer Care Services
 Benjamin Marchello, MD
Ph: 406-238-6290
  Butte
 St. James Healthcare Cancer Care
 Benjamin Marchello, MD
Ph: 406-238-6290
  Great Falls
 Benjamin Marchello, MD
Ph: 406-238-6290
 Great Falls Clinic - Main Facility
 Benjamin Marchello, MD
Ph: 406-238-6290
  Havre
 Northern Montana Hospital
 Benjamin Marchello, MD
Ph: 406-238-6290
  Kalispell
 Glacier Oncology, PLLC
 Benjamin Marchello, MD
Ph: 406-238-6290
 Kalispell Medical Oncology at KRMC
 Benjamin Marchello, MD
Ph: 406-238-6290
 Kalispell Regional Medical Center
 Benjamin Marchello, MD
Ph: 406-238-6290
  Missoula
 Community Medical Center
 Benjamin Marchello, MD
Ph: 406-238-6290
 Guardian Oncology and Center for Wellness
 Benjamin Marchello, MD
Ph: 406-238-6290
 Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
 Clinical Trials Office - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Ph: 406-329-7029
 Montana Cancer Specialists at Montana Cancer Center
 Clinical Trials Office - Montana Cancer Specialists at Montana Cancer Center
Ph: 406-238-6962
Nebraska
  Grand Island
 Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
 Elizabeth Reed, MD
Ph: 402-559-5388
  Kearney
 Good Samaritan Cancer Center at Good Samaritan Hospital
 Clinical Trials Office - Good Samaritan Cancer Center at Good Samaritan Hospital
Ph: 308-865-7963
  Lincoln
 Cancer Resource Center - Lincoln
 Alan Berg, MD
Ph: 402-420-7000
  North Platte
 Callahan Cancer Center at Great Plains Regional Medical Center
 Clinical Trials Office - Callahan Cancer Center at Great Plains Regional Medical Center
Ph: 308-696-7864
  Omaha
 Alegant Health Cancer Center at Bergan Mercy Medical Center
 Clinical Trials Office - Alegant Health Cancer Center at Bergen Mercy Medical Center
Ph: 402-398-6060
 CCOP - Missouri Valley Cancer Consortium
 Gamini Soori, MD, FACP, FRCP, MBA
Ph: 402-393-3110
 Creighton University Medical Center
 Clinical Trials Office - Creighton University Medical Center
Ph: 402-280-4100
 Immanuel Medical Center
 Gamini Soori, MD, FACP, FRCP, MBA
Ph: 402-393-3110
 Methodist Estabrook Cancer Center
 Robert Langdon, MD
Ph: 402-399-8762
 UNMC Eppley Cancer Center at the University of Nebraska Medical Center
 Clinical Trials Office - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Ph: 800-999-5465
Nevada
  Las Vegas
 CCOP - Nevada Cancer Research Foundation
 John Ellerton, MD, CM
Ph: 702-384-0013
 University Medical Center of Southern Nevada
 John Ellerton, MD, CM
Ph: 702-384-0013
New Hampshire
  Concord
 New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
 Charles Catcher, MD
Ph: 603-224-2556
  Hooksett
 New Hampshire Oncology - Hematology, PA - Hooksett
 Charles Catcher, MD
Ph: 603-224-2556
  Keene
 Kingsbury Center for Cancer Care at Cheshire Medical Center
 Marc Ernstoff, MD
Ph: 603-650-5534
  Lebanon
 Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
 Clinical Trials Office - Norris Cotton Cancer Center
Ph: 603-650-7609
 Email: cancerhelp@dartmouth.edu
  Manchester
 Elliot Regional Cancer Center at Elliot Hospital
 Douglas Weckstein, MD
Ph: 603-622-6484
New Jersey
  Hackensack
 CCOP - Northern New Jersey
 Norman Rosenblum, MD, PhD
Ph: 215-955-6200
  Hamilton
 Cancer Institute of New Jersey at Hamilton
 Clinical Trials Office - Cancer Institute of New Jersey at Hamilton
Ph: 609-631-6946
  Livingston
 St. Barnabas Medical Center Cancer Center
 Clinical Trials Office - St. Barnabas Medical Center Cancer Center
Ph: 973-322-2470
  Marlton
 Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
 Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Ph: 888-847-8823
  Morristown
 Carol G. Simon Cancer Center at Morristown Memorial Hospital
 Daniel Moriarty, MD
Ph: 908-608-0078
  New Brunswick
 Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
 Clinical Trials Office - Cancer Institute of New Jersey
Ph: 732-235-8675
  Phillipsburg
 Warren Hospital
 Clinical Trials Office - Warren Hospital
Ph: 908-387-6038
  Red Bank
 Booker Cancer Center at Riverview Medical Center
 Denis Fitzgerald, MD
Ph: 732-530-8666
  Summit
 Overlook Hospital
 Daniel Moriarty, MD
Ph: 908-608-0078
  Trenton
 St. Francis Regional Cancer Center
 Clinical Trials Office - St. Francis Regional Cancer Center
Ph: 609-599-5060
  Voorhees
 Cancer Institute of New Jersey at Cooper - Voorhees
 Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees
Ph: 856-325-6757
 Fox Chase Virtua Health Cancer Program at Virtua West Jersey
 Michael Entmacher, MD
Ph: 609-702-1900
New York
  Albany
 New York Oncology Hematology, PC at Albany Regional Cancer Care
 John Ferraro, MD
Ph: 518-786-3122
  Bronx
 Albert Einstein Cancer Center at Albert Einstein College of Medicine
 Clinical Trials Office - Albert Einstein Cancer Center at Albert Einstein College of Medicine
Ph: 718-904-2730
 Email: aecc@aecom.yu.edu
  Buffalo
 Roswell Park Cancer Institute
 Clinical Trials Office - Roswell Park Cancer Institute
Ph: 877-275-7724
  Clifton Springs
 Finger Lakes Hematology and Oncology
 Bruce Yirinec, MD
Ph: 315-462-6929
  East Syracuse
 CCOP - Hematology-Oncology Associates of Central New York
 Jeffrey Kirshner, MD
Ph: 315-472-7504
  Glens Falls
 Adirondack Cancer Care - Glens Falls
 Mark Hoffman, MD
Ph: 518-761-0000
 Charles R. Wood Cancer Center at Glens Falls Hospital
 Clinical Trials Office - Charles R. Wood Cancer Center at Glens Falls Hospital
Ph: 518-926-6700
  Lake Success
 Monter Cancer Center of the North Shore-LIJ Health System
 Vincent Vinciguerra, MD
Ph: 516-734-8954
  Latham
 New York Oncology Hematology, PC - Latham
 John Ferraro, MD
Ph: 518-786-3122
  Manhasset
 CCOP - North Shore University Hospital
 Vincent Vinciguerra, MD
Ph: 516-734-8954
 Don Monti Comprehensive Cancer Center at North Shore University Hospital
 Clinical Trials Office - Don Monti Comprehensive Cancer Center at North Shore University Hospital
Ph: 516-734-8900
  New Hyde Park
 Long Island Jewish Medical Center
 Vincent Vinciguerra, MD
Ph: 516-734-8954
  New York
 Memorial Sloan-Kettering Cancer Center
 Diana Lake, MD
Ph: 212-639-8953
 Mount Sinai Medical Center
 Lewis Silverman, MD
Ph: 212-241-5520
 NYU Cancer Institute at New York University Medical Center
 Howard Hochster, MD
Ph: 212-731-5100
 Ralph Lauren Center for Cancer Care and Prevention
 Diana Lake, MD
Ph: 212-639-8953
 St. Vincent's Comprehensive Cancer Center - Manhattan
 Clinical Trials Office - St. Vincent's Comprehensive Cancer Center - Manhattan
Ph: 212-367-1729
  Rochester
 Lipson Cancer and Blood Center at Rochester General Hospital
 Peter Bushunow, MD
Ph: 585-922-4020
  Stony Brook
 Stony Brook University Cancer Center
 Clinical Trials Office - Stony Brook University Cancer Center
Ph: 800-862-2215
  Syracuse
 SUNY Upstate Medical University Hospital
 Clinical Trials Office - SUNY Upstate Medical University Hospital
Ph: 315-464-5476
 Veterans Affairs Medical Center - Syracuse
 Ajeet Gajra, MD
Ph: 315-425-4666
  Utica
 Faxton Regional Cancer Center
 Atul Butala, MD, FACP
Ph: 315-798-9300
North Carolina
  Charlotte
 Presbyterian Cancer Center at Presbyterian Hospital
 Clinical Trials Office - Presbyterian Cancer Center at Presbyterian Hospital
Ph: 704-384-5369
  Concord
 Batte Cancer Center at Northeast Medical Center
 James Wall, MD
Ph: 704-783-1370
  Durham
 Duke Comprehensive Cancer Center
 Clinical Trials Office - Duke Comprehensive Cancer Center
Ph: 888-275-3853
  Fayetteville
 Cape Fear Valley Medical Center Cancer Center
 Clinical Trial Office - Cape Fear Valley Medical Center Cancer Center
Ph: 910-609-4561
  Goldsboro
 Wayne Memorial Hospital, Incorporated
 James Atkins, MD
Ph: 919-580-0000
  Pinehurst
 FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
 Clinical Trials Office - FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
Ph: 910-715-2200
  Rutherfordton
 Rutherford Hospital
 James Bearden, MD
Ph: 864-560-6812
  Wilmington
 Zimmer Cancer Center at New Hanover Regional Medical Center
 Cyrus Kotwall, MD
Ph: 910-763-4630
  Winston-Salem
 Forsyth Regional Cancer Center at Forsyth Medical Center
 Clinical Trials Office - Forsyth Regional Cancer Center at Forsyth Medical Center
Ph: 336-277-8887
North Dakota
  Bismarck
 Bismarck Cancer Center
 Edward Wos, DO
Ph: 701-323-5741
 Medcenter One Hospital Cancer Care Center
 Edward Wos, DO
Ph: 701-323-5741
 Mid Dakota Clinic, PC
 Clinical Trials Office - Mid Dakota Clinic, PC
Ph: 701-530-6950
 St. Alexius Medical Center Cancer Center
 Clinical Trials Office - St. Alexius Medical Center Cancer Center
Ph: 701-530-6950
  Fargo
 CCOP - MeritCare Hospital
 Preston Steen, MD
Ph: 701-234-2397
 MeritCare Broadway
 Preston Steen, MD
Ph: 701-234-2397
  Grand Forks
 Altru Cancer Center at Altru Hospital
 Clinical Trails Office - Altru Cancer Center at Altru Hospital
Ph: 701-780-6520
Ohio
  Akron
 McDowell Cancer Center at Akron General Medical Center
 Esther Rehmus, MD
Ph: 330-344-6505
  Beachwood
 Cleveland Clinic Beachwood Family Health and Surgery Center
 George Budd, MD
Ph: 216-444-6480
  Bellefontaine
 Mary Rutan Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Bowling Green
 Wood County Oncology Center
 Paul Schaefer, MD
Ph: 419-479-5605
  Canton
 Aultman Cancer Center at Aultman Hospital
 Clinical Trials Office - Aultman Cancer Center at Aultman Hospital
Ph: 330-363-6891
 Mercy Cancer Center at Mercy Medical Center
 Mitchell Haut, MD
Ph: 330-453-9993
  Chillicothe
 Adena Regional Medical Center
 Clinical Trials Office - Adena Regional Medical Center
Ph: 877-779-7585
  Cleveland
 Case Comprehensive Cancer Center
 Clinical Trials Office - Case Comprehensive Cancer Center
Ph: 800-641-2422
 Cleveland Clinic Cancer Center at Fairview Hospital
 Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital
Ph: 216-476-9362
 Cleveland Clinic Taussig Cancer Center
 Clinical Trials Office - Cleveland Clinic Taussig Cancer Center
Ph: 866-223-8100
 MetroHealth Cancer Care Center at MetroHealth Medical Center
 Bruce Averbook, MD, FACS
Ph: 216-778-4795
  Columbus
 Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
 Ohio State University Cancer Clinical Trial Matching Service
Ph: 866-627-7616
 Email: osu@emergingmed.com
 CCOP - Columbus
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
 Doctors Hospital at Ohio Health
 Clinical Trials Office - Doctors Hospital at Ohio Health
Ph: 614-566-3275
 Grant Medical Center Cancer Care
 Clinical Trials Office - Grant Medical Center Cancer Care
Ph: 614-566-4475
 Mount Carmel Health - West Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
 Riverside Methodist Hospital Cancer Care
 Clinical Trials Office - Riverside Methodist Hospital Cancer Care
Ph: 614-566-4475
  Dayton
 CCOP - Dayton
 Howard Gross, MD
Ph: 937-832-1093
 David L. Rike Cancer Center at Miami Valley Hospital
 Clinical Trials Office - David L. Rike Cancer Center at Miami Valley Hospital
Ph: 937-208-2079
 Good Samaritan Hospital
 Howard Gross, MD
Ph: 937-832-1093
 Grandview Hospital
 Howard Gross, MD
Ph: 937-832-1093
 Samaritan North Cancer Care Center
 Howard Gross, MD
Ph: 937-832-1093
  Delaware
 Grady Memorial Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Elyria
 Hematology Oncology Center
 Paul Schaefer, MD
Ph: 419-479-5605
  Findlay
 Blanchard Valley Medical Associates
 Howard Gross, MD
Ph: 937-832-1093
  Franklin
 Middletown Regional Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Greenville
 Wayne Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Independence
 Cleveland Clinic Cancer Center
 George Budd, MD
Ph: 216-444-6480
  Kettering
 Charles F. Kettering Memorial Hospital
 Clinical Trials Office - Charles F. Kettering Memorial Hospital
Ph: 937-298-3399 ext. 57556
  Lancaster
 Fairfield Medical Center
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Lima
 Lima Memorial Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
  Mansfield
 MedCentral - Mansfield Hospital
 Clinical Trials Office - MedCentral - Mansfield Hospital
Ph: 419-526-8938
  Marietta
 Strecker Cancer Center at Marietta Memorial Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Maumee
 Northwest Ohio Oncology Center
 Paul Schaefer, MD
Ph: 419-479-5605
 Paul Schaefer, MD
Ph: 419-479-5605
 St. Luke's Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
  Mayfield Heights
 Hillcrest Cancer Center at Hillcrest Hospital
 George Budd, MD
Ph: 216-444-6480
  Newark
 Licking Memorial Cancer Care Program at Licking Memorial Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Oregon
 St. Charles Mercy Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
 Toledo Clinic - Oregon
 Paul Schaefer, MD
Ph: 419-479-5605
  Sandusky
 North Coast Cancer Care, Incorporated
 Paul Schaefer, MD
Ph: 419-479-5605
  Springfield
 Community Hospital of Springfield and Clark County
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
 Mercy Medical Center
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Sylvania
 Flower Hospital Cancer Center
 Clinical Trials Office - Flower Hospital Cancer Center
Ph: 419-824-1842
  Tiffin
 Mercy Hospital of Tiffin
 Paul Schaefer, MD
Ph: 419-479-5605
  Toledo
 CCOP - Toledo Community Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
 Medical University of Ohio Cancer Center
 Clinical Trials Office - Medical University of Ohio Cancer Center
Ph: 419-383-6583
 St. Vincent Mercy Medical Center
 Paul Schaefer, MD
Ph: 419-479-5605
 Toledo Clinic, Incorporated - Main Clinic
 Paul Schaefer, MD
Ph: 419-479-5605
 Toledo Hospital
 Clinical Trials Office - Toledo Hospital
Ph: 419-824-1842
  Troy
 UVMC Cancer Care Center at Upper Valley Medical Center
 Clinical Trials Office - UVMC Cancer Care Center at Upper Valley Medical Center
Ph: 937-440-4842
  Wauseon
 Fulton County Health Center
 Clinical Trials Office - Fulton County Health Center
Ph: 419-330-2708
  Westerville
 Mount Carmel St. Ann's Cancer Center
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Wilmington
 Clinton Memorial Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Wooster
 Cleveland Clinic - Wooster
 Clinical Trials Office - Cleveland Clinic - Wooster
Ph: 800-862-7798
  Wright-Patterson Afb
 United States Air Force Medical Center - Wright-Patterson
 Roger Wood
Ph: 937-257-9133
  Xenia
 Ruth G. McMillan Cancer Center at Greene Memorial Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Zanesville
 Genesis - Good Samaritan Hospital
 Clinical Trials Office - Genesis - Good Samaritan Hospital
Ph: 740-454-5232
Oklahoma
  Tulsa
 Natalie Warren Bryant Cancer Center at St. Francis Hospital
 David Barnes, MD, FACS
Ph: 423-778-8582
Oregon
  Bend
 St. Charles Medical Center - Bend
 Robert Boone, MD
Ph: 541-317-4298
  Grants Pass
 Three Rivers Community Hospital
 Charles Dibb, MD
Ph: 541-774-5853
  Gresham
 Legacy Mount Hood Medical Center
 Clinical Trials Office - Legacy Mount Hood Medical Center
Ph: 503-413-2150
  Medford
 Dubs Cancer Center at Rogue Valley Medical Center
 Charles Dibb, MD
Ph: 541-774-5853
 Providence Cancer Center at PMCC
 Charles Dibb, MD
Ph: 541-774-5853
  Milwaukie
 Providence Milwaukie Hospital
 Keith Lanier, MD
Ph: 503-299-6500
  Portland
 Adventist Medical Center
 Keith Lanier, MD
Ph: 503-299-6500
 CCOP - Columbia River Oncology Program
 Keith Lanier, MD
Ph: 503-299-6500
 Kaiser Permanente Health Care - Portland
 Nagendra Tirumali, MD
Ph: 503-331-6500
 Legacy Emanuel Hospital and Health Center and Children's Hospital
 Clinical Trials Office - Legacy Emanuel Hospital and Health Center and Children's Hospital
Ph: 503-413-8199
 Legacy Good Samaritan Hospital & Comprehensive Cancer Center
 Clinical Trials Office - Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Ph: 503-413-1742
 Providence Cancer Center at Providence Portland Medical Center
 Clinical Trials Office - Providence Cancer Center at Providence Portland Medical Center
Ph: 503-215-6412
 Providence St. Vincent Medical Center
 Clinical Trials Office - Providence St. Vincent Medical Center
Ph: 503-215-6412
  Tualatin
 Legacy Meridian Park Hospital
 Clinical Trials Office - Legacy Meridian Park Hospital
Ph: 503-413-1742
Pennsylvania
  Allentown
 Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
 Eliot Friedman, MD
Ph: 610-402-0512
  Bryn Mawr
 Bryn Mawr Hospital
 Clinical Trials Office - Bryn Mawr Hospital
Ph: 610-645-2680
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Clinical Trials Office - Geisinger Cancer Institute
Ph: 570-271-5251
  Darby
 Mercy Fitzgerald Hospital
 Clinical Trials Office - Mercy Fitzgerald Hospital
Ph: 610-237-4982
  Drexel Hill
 Delaware County Regional Cancer Center at Delaware County Memorial Hospital
 Marc Rovito, MD
Ph: 610-622-3818
  Harrisburg
 PinnacleHealth Regional Cancer Center at Polyclinic Hospital
 Oncology Clinical Trial Coordinator
Ph: 717-782-4750
  Hershey
 Penn State Cancer Institute at Milton S. Hershey Medical Center
 Clinical Trials Office - Penn State Cancer Institute at Milton S. Hershey Medical Center
Ph: 717-531-3779
 Email: CTO@hmc.psu.edu
  Lemoyne
 Central Pennsylvania Hematology and Medical Oncology Associates, PC
 John Conroy, DO, FACP, FACOI
Ph: 717-737-5767
  Lewistown
 Lewistown Hospital
 Harold Harvey, MD
Ph: 717-531-8677
  Paoli
 Cancer Center of Paoli Memorial Hospital
 Clinical Trials Office - Cancer Center of Paoli Memorial Hospital
Ph: 610-648-1637
  Philadelphia
 Abramson Cancer Center of the University of Pennsylvania
 Clinical Trials Office - Abramson Cancer Center of the University of Pennsylvania
Ph: 800-474-9892
 Fox Chase Cancer Center - Philadelphia
 Clinical Trials Office - Fox Chase Cancer Center - Philadelphia
Ph: 215-728-4790
 Frankford Hospital Cancer Center - Torresdale Campus
 Edith Mitchell, MD, FACP
Ph: 215-955-8874
 Joan Karnell Cancer Center at Pennsylvania Hospital
 Bernard Mason, MD
Ph: 215-829-6088
 Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
 Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Ph: 215-955-6084
  Pottstown
 Pottstown Memorial Regional Cancer Center
 Wei Song, MD, PhD
Ph: 610-327-7555
  Reading
 McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
 Clinical Trials Office - McGlinn Family Regional Cancer Center
Ph: 610-988-9323
  Scranton
 Hematology and Oncology Associates of Northeastern Pennsylvania
 Martin Hyzinski, MD
Ph: 570-558-3020
 William Heim, MD
Ph: 570-342-3675
 Mercy Hospital Cancer Center - Scranton
 William Heim, MD
Ph: 570-342-3675
  Sellersville
 Grand View Hospital
 Anthony Magdalinski, III
Ph: 215-453-4000
  State College
 Geisinger Medical Group - Scenery Park
 Albert Bernath, MD
Ph: 570-214-9290
 Mount Nittany Medical Center
 Harold Harvey, MD
Ph: 717-531-8677
  Wilkes-Barre
 Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
 Clinical Trials Office - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Ph: 570-271-5251
  Williamsport
 Susquehanna Cancer Center at Divine Providence Hospital
 Warren Robinson, Jr.
Ph: 570-326-8000
  Wynnewood
 CCOP - Main Line Health
 Paul Gilman, MD
Ph: 610-645-2000
 Lankenau Cancer Center at Lankenau Hospital
 Paul Gilman, MD
Ph: 610-645-2000
Rhode Island
  Providence
 Miriam Hospital
 Clinical Trials Office - Miriam Hospital
Ph: 401-793-2224
 Rhode Island Hospital Comprehensive Cancer Center
 Clinical Trials Office - Rhode Island Hospital Comprehensive Cancer Center
Ph: 401-444-1488
South Carolina
  Anderson
 AnMed Cancer Center
 Clinical Trials Office - AnMed Cancer Center
Ph: 864-512-1000
  Charleston
 Hollings Cancer Center at Medical University of South Carolina
 Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina
Ph: 843-792-9321
  Florence
 McLeod Regional Medical Center
 Clinical Trials Office - McLeod Regional Medical Center
Ph: 843-679-7256
  Greenville
 CCOP - Greenville
 Jeffrey Giguere, MD, FACP
Ph: 864-987-7000
  Spartanburg
 CCOP - Upstate Carolina
 Clinical Trials Office - CCOP - Upstate Carolina
Ph: 800-486-5941
 Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
 Clinical Trials Office - Gibbs Regional Cancer Center
Ph: 800-486-5941
South Dakota
  Rapid City
 Rapid City Regional Hospital
 Richard Tenglin
Ph: 605-719-2360
  Sioux Falls
 Avera Cancer Institute
 Loren Tschetter, MD
Ph: 605-328-8000
 Medical X-Ray Center, PC
 Loren Tschetter, MD
Ph: 605-328-8000
 Sanford Cancer Center at Sanford USD Medical Center
 Clinical Trials Office - Sanford Cancer Center
Ph: 605-328-1367
Tennessee
  Knoxville
 Baptist Regional Cancer Center at Baptist Riverside
 Clinical Trials Office - Baptist Regional Cancer Center
Ph: 865-632-5717
 U.T. Medical Center Cancer Institute
 Clinical Trials Office - U.T. Medical Center Cancer Institute
Ph: 865-544-9773
  Nashville
 Vanderbilt-Ingram Cancer Center
 Clinical Trials Office - Vanderbilt-Ingram Cancer Center
Ph: 1-800-811-8480;
Texas
  Amarillo
 Harrington Cancer Center
 Clinical Trials Officec - Harrington Cancer Center
Ph: 806-359-4673
 Email: ryokubaitis@harringtoncc.org
  Dallas
 Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
 Clinical Trials Office - Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Ph: 866-460-4673; 214-648-7097
  San Antonio
 South Texas Oncology and Hematology - Wurzbach Road
 Clinical Trials Office - South Texas Oncology and Hematology - Wurzbach Road
Ph: 210-593-2651
Utah
  Salt Lake City
 Huntsman Cancer Institute at University of Utah
 Clinical Trials Office - Huntsman Cancer Institute at University of Utah
Ph: 801-581-4477
 Email: clinical.trials@hci.utah.edu
Vermont
  Berlin
 Mountainview Medical
 John Valentine, MD
Ph: 802-223-6196
  Burlington
 Fletcher Allen Health Care - University Health Center Campus
 Clinical Trials Office - Fletcher Allen Health Care
Ph: 802-656-8990
Virginia
  Charlottesville
 University of Virginia Cancer Center
 Geoffrey Weiss, MD
Ph: 434-243-0066
  Danville
 Danville Regional Medical Center
 Clinical Trials Office - Danville Regional Medical Center
Ph: 434-799-3753
  Falls Church
 Inova Fairfax Hospital
 Clinical Trials Office - Inova Fairfax Hospital
Ph: 703-208-6650
  Fredericksburg
 Fredericksburg Oncology, Incorporated
 Paul Schaefer, MD
Ph: 419-479-5605
  Hampton
 Virginia Oncology Associates - Hampton
 Paul Conkling, MD
Ph: 757-466-8683
Washington
  Auburn
 Auburn Regional Center for Cancer Care
 Lauren Colman, MD
Ph: 253-403-1677
  Bellingham
 St. Joseph Cancer Center
 Saul Rivkin, MD
Ph: 206-386-2441
  Bremerton
 Olympic Hematology and Oncology
 Saul Rivkin, MD
Ph: 206-386-2441
  Centralia
 Providence Centralia Hospital
 Clinical Trials Office - Providence Centralia Hospital
Ph: 360-493-4300
  Federal Way
 St. Francis Hospital
 Lauren Colman, MD
Ph: 253-403-1677
  Kennewick
 Columbia Basin Hematology
 Saul Rivkin, MD
Ph: 206-386-2441
  Olympia
 Providence St. Peter Hospital Regional Cancer Center
 Lauren Colman, MD
Ph: 253-403-1677
  Port Angeles
 Olympic Medical Center
 Jacqueline Vuky
Ph: 360-417-7139
  Puyallup
 Good Samaritan Cancer Center
 Lauren Colman, MD
Ph: 253-403-1677
  Seattle
 CCOP - Virginia Mason Research Center
 Jacqueline Vuky
Ph: 206-341-0446
 Fred Hutchinson Cancer Research Center
 Saul Rivkin, MD
Ph: 206-386-2441
 Group Health Central Hospital
 Clinical Trials Office - Group Health Central Hospital
Ph: 206-287-2900
 Harborview Medical Center
 Saul Rivkin, MD
Ph: 206-386-2441
 Minor and James Medical, PLLC
 Saul Rivkin, MD
Ph: 206-386-2441
 Polyclinic First Hill
 Saul Rivkin, MD
Ph: 206-386-2441
 Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
 Saul Rivkin, MD
Ph: 206-386-2441
 University Cancer Center at University of Washington Medical Center
 Clinical Trials Office - University Cancer Center at University of Washington Medical Center
Ph: 206-616-8289
  Spokane
 Cancer Care Northwest - Spokane South
 Clinical Trials Office - Cancer Care Northwest - Spokane South
Ph: 509-228-1083
 Rockwood Clinic Cancer Treatment Center
 Clinical Trials Office - Rockwood Clinic Cancer Treatment Center
Ph: 509-838-2531 ext. 6880
  Tacoma
 Allenmore Hospital
 Lauren Colman, MD
Ph: 253-403-1677
 CCOP - Northwest
 Lauren Colman, MD
Ph: 253-403-1677
 Franciscan Cancer Center at St. Joseph Medical Center
 Clinical Trials Office - Franciscan Cancer Center
Ph: 253-426-6914
 MultiCare Regional Cancer Center at Tacoma General Hospital
 Clinical Trials Office - MultiCare Regional Cancer Center
Ph: 253-403-3229
 St. Clare Hospital
 Lauren Colman, MD
Ph: 253-403-1677
  Vancouver
 Southwest Washington Medical Center Cancer Center
 Keith Lanier, MD
Ph: 503-299-6500
  Yakima
 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
 Clinical Trails Office - North Star Lodge Cancer Center
Ph: 509-574-3422
Wisconsin
  Eau Claire
 Center for Cancer Treatment & Prevention at Sacred Heart Hospital
 Matthias Weiss, MD
Ph: 715-358-1266
 Marshfield Clinic Cancer Care at Regional Cancer Center
 Matthias Weiss, MD
Ph: 715-358-1266
  Green Bay
 Green Bay Oncology, Limited at St. Mary's Hospital
 Gerald Bayer, MD
Ph: 920-432-6049
 Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
 Gerald Bayer, MD
Ph: 920-432-6049
 St. Mary's Hospital Medical Center - Green Bay
 Gerald Bayer, MD
Ph: 920-432-6049
 St. Vincent Hospital Regional Cancer Center
 Clinical Trials Office - St. Vincent Hospital Regional Cancer Center
Ph: 920-433-8889
  La Crosse
 Franciscan Skemp Healthcare - La Crosse Campus
 James Edward Novotny, MD
Ph: 608-785-0940ext.6411
 Gundersen Lutheran Center for Cancer and Blood
 Clinical Trials Office - Gundersen Lutheran Cancer Center
Ph: 608-775-2385
 Email: cancerctr@gundluth.org
  Madison
 University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
 Clinical Trials Office - University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Ph: 608-262-5223
  Marinette
 Bay Area Cancer Care Center at Bay Area Medical Center
 Gerald Bayer, MD
Ph: 920-432-6049
  Marshfield
 Marshfield Clinic - Marshfield Center
 Clinical Trials Office - Marshfield Clinic - Marshfield Center
Ph: 800-782-1581 ext. 94457
 Saint Joseph's Hospital
 Matthias Weiss, MD
Ph: 715-358-1266
  Milwaukee
 Aurora Sinai Medical Center
 Clinical Trials Office - Aurora Sinai Medical Center
Ph: 414-649-5717
 Medical Consultants, Limited
 Jonathan Treisman, MD
Ph: 414-385-3086
  Minocqua
 Marshfield Clinic - Lakeland Center
 Matthias Weiss, MD
Ph: 715-358-1266
  Oconomowoc
 Regional Cancer Center at Oconomowoc Memorial Hospital
 Clinical Trials Office - Regional Cancer Center at Oconomowoc Memorial Hospital
Ph: 262-928-7878
  Rhinelander
 Ministry Medical Group at Saint Mary's Hospital
 Matthias Weiss, MD
Ph: 715-358-1266
  Rice Lake
 Marshfield Clinic - Indianhead Center
 Matthias Weiss, MD
Ph: 715-358-1266
  Stevens Point
 Saint Michael's Hospital Cancer Center
 Matthias Weiss, MD
Ph: 715-358-1266
  Waukesha
 Waukesha Memorial Hospital Regional Cancer Center
 Clinical Trials Office - Waukesha Memorial Hospital Regional Cancer Center
Ph: 262-928-7632
  Wausau
 Marshfield Clinic - Wausau Center
 Matthias Weiss, MD
Ph: 715-358-1266
 University of Wisconcin Cancer Center at Aspirus Wausau Hospital
 Clinical Trials Office - University of Wisconsin Cancer Center
Ph: 608-262-5223
  Weston
 Marshfield Clinic - Weston Center
 Matthias Weiss, MD
Ph: 715-358-1266
  Wisconsin Rapids
 Marshfield Clinic - Wisconsin Rapids Center
 Matthias Weiss, MD
Ph: 715-358-1266
Canada
Alberta
  Lethbridge
 Lethbridge Cancer Centre
 Chi Cheong Au
Ph: 403-328-6641
British Columbia
  Kelowna
 British Columbia Cancer Agency - Centre for the Southern Interior
 Susan Ellard
Ph: 250-712-3922
  Penticton
 Penticton Regional Hospital
 Saroosh Arif
Ph: 250-492-9032
  Surrey
 BCCA - Fraser Valley Cancer Centre
 Gary K. Pansegrau
Ph: 604-930-4064
  Vancouver
 British Columbia Cancer Agency - Vancouver Cancer Centre
 Stephen Chia
Ph: 604-877-6000
  Victoria
 British Columbia Cancer Agency - Vancouver Island Centre
 Sharon Allan
Ph: 250-519-5570
Manitoba
  Winnipeg
 CancerCare Manitoba
 Andrew L. Cooke
Ph: 204-787-1458
New Brunswick
  Moncton
 Doctor Leon Richard Oncology Centre
 Pierre Whitlock
Ph: 506-862-4030
 Moncton Hospital
 Sheldon Rubin
Ph: 506-857-2881
  Saint John
 Saint John Regional Hospital
 S. Eshwar Kumar
Ph: 506-648-6884
Newfoundland and Labrador
  St. John's
 Doctor H. Bliss Murphy Cancer Centre
 Pradip K. Ganguly
Ph: 709-777-7805
Nova Scotia
  Halifax
 Nova Scotia Cancer Centre
 Daniel Rayson
Ph: 902-473-6106
Ontario
  Barrie
 Royal Victoria Hospital of Barrie
 Bryn Pressnail
Ph: 705-728-9090
  Hamilton
 Margaret and Charles Juravinski Cancer Centre
 Richard G. Tozer
Ph: 905-387-9495
  Kingston
 Cancer Centre of Southeastern Ontario at Kingston General Hospital
 Wendy Shelley
Ph: 613-544-2630
  London
 London Regional Cancer Program at London Health Sciences Centre
 Francisco Perera
Ph: 519-685-8500
  Markham
 Markham Stouffville Hospital
 Henry L. Solow
Ph: 905-472-7072
  Mississauga
 Carlo Fidani Peel Regional Cancer Centre at Credit Valley Hospital
 Robert Myers
Ph: 905-813-1100
 Trillium Health Centre - Mississauga Site
 John A.P. Gapski
Ph: 905-848-7147
  Newmarket
 Southlake Regional Health Centre
 Labib A. Zibdawi
Ph: 905-895-4521
  Oshawa
 R. S. McLaughlin Durham Regional Cancer Centre at Lakeridge Health Oshawa
 Jose Chang
Ph: 905-576-8711
  Ottawa
 Ottawa Hospital Regional Cancer Centre - General Campus
 Rakesh Goel
Ph: 613-737-7700
  Sault Ste. Marie
 Algoma District Cancer Program at Sault Area Hospital
 David Walde
Ph: 705-759-3815
  St. Catharines
 St. Catharines General Hospital at Niagara Health System
 Brian Findlay
Ph: 905-684-7271
  Sudbury
 Northeastern Ontario Regional Cancer Centre
 Pedro G. Lopez
Ph: 705-522-6237
  Thunder Bay
 Cancer Care Program at Thunder Bay Regional Health Sciences
 Dimitrios Vergidis
Ph: 807-684-7204
  Toronto
 Edmond Odette Cancer Centre at Sunnybrook
 Kathleen I. Pritchard
Ph: 416-480-4616
 Humber River Regional Hospital - Weston
 Jonathan J. Wilson
Ph: 416-249-4367
 Mount Sinai Hospital - Toronto
 Martin Blackstein
Ph: 416-586-5371
 New Women's College Hospital
 Maureen E. Trudeau
Ph: 416-480-5145
 North York General Hospital - Ontario
 Vivian Glenns
Ph: 416-498-4888
 Princess Margaret Hospital
 David Warr
Ph: 416-946-2260
 St. Joseph's Health Centre - Toronto
 Murray Davidson
Ph: 416-766-2365
 St. Michael's Hospital - Toronto
 Rashida Haq
Ph: 416-864-5912
 Toronto East General Hospital
 Yasmin H. Rahim
Ph: 416-469-3325
  Windsor
 Windsor Regional Cancer Centre at Windsor Regional Hospital
 Caroline Hamm
Ph: 519-253-5253
Prince Edward Island
  Charlottetown
 Prince Edward Island Cancer Centre at Queen Elizabeth Hospital
 Dagny Dryer
Ph: 902-894-2027
Quebec
  Levis
 Hotel-Dieu de Levis
 Felix Couture
Ph: 418-691-5225
  Montreal
 CHUM - Hopital Saint-Luc
 Edgard Nassif
Ph: 514-890-8000
 CHUM - Hotel Dieu Hospital
 Claude Potvin
Ph: 514-890-8000
 Hopital Notre-Dame du CHUM
 Mate Poljicak
Ph: 514-890-8000
 Maisonneuve-Rosemont Hospital
 Pierre Dube
Ph: 514-252-3822
 McGill Cancer Centre at McGill University
 Francois Patenaude
Ph: 514-934-1934
  Quebec
 L'Hopital Laval
 Stefane Lebel
Ph: 418-656-4810
  Quebec City
 Centre Hospitalier Universitaire de Quebec
 Felix Couture
Ph: 418-691-5225
 Hopital du Saint-Sacrement - Quebec
 Jean Robert
Ph: 418-682-7511
  Sherbrooke
 CHUS-Hopital Fleurimont
 Abdenour Nabid
Ph: 819-346-1110
Saskatchewan
  Regina
 Allan Blair Cancer Centre at Pasqua Hospital
 Haji Ibrahim Chalchal
Ph: 306-766-2691
  Saskatoon
 Saskatoon Cancer Centre at the University of Saskatchewan
 Ali El-Gayed
Ph: 306-655-2739

Registry Information
Official Title A Phase III Randomized Double Blind Study of Vorozole Versus Placebo in Women with Primary Breast Cancer Completing Five or More Years of Adjuvant Tamoxifen
Trial Start Date 1998-08-24
Trial Completion Date 2002-09-02
Registered in ClinicalTrials.gov NCT00003140
Date Submitted to PDQ 1997-11-12
Information Last Verified 2009-05-08
NCI Grant/Contract Number CA25224

Note: The purpose of most clinical trials listed in this database is to test new cancer treatments, or new methods of diagnosing, screening, or preventing cancer. Because all potentially harmful side effects are not known before a trial is conducted, dose and schedule modifications may be required for participants if they develop side effects from the treatment or test. The therapy or test described in this clinical trial is intended for use by clinical oncologists in carefully structured settings, and may not prove to be more effective than standard treatment. A responsible investigator associated with this clinical trial should be consulted before using this protocol.

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