Premenopausal, ER-positive or PR-positive |
None or tamoxifen |
Tamoxifen plus chemotherapy, tamoxifen alone, ovarian ablation, GnRH analog* |
Chemotherapy plus tamoxifen, chemotherapy plus ablation or GnRH analog*, chemotherapy plus tamoxifen plus ovarian ablation or GnRH*, or ovarian ablation alone or with tamoxifen or GnRH alone or with tamoxifen |
Premenopausal, ER-negative or PR-negative |
— |
— |
Chemotherapy |
Postmenopausal, ER-positive or PR-positive |
None or tamoxifen |
Tamoxifen plus chemotherapy, tamoxifen alone |
Tamoxifen plus chemotherapy, tamoxifen alone |
Postmenopausal, ER-negative or PR-negative |
— |
— |
Chemotherapy |
Older than 70 years |
None or tamoxifen |
Tamoxifen alone, tamoxifen plus chemotherapy |
Tamoxifen; consider chemotherapy if ER-negative or PR-negative |