B.A., San Francisco State University, 1984
M.S., San Francisco State University, 1986
Ph.D., University of California, San Francisco, 1990
Research Statement
The laboratory takes a structural approach to understanding fundamental mechanisms in cell signaling and trafficking. We have particular emphases on large multiprotein complexes and on understanding the role of phosphoinositides and other lipids in signaling and trafficking. Many of the pathways studied in the lab are relevant to the molecular-level understanding type II diabetes, obesity, AIDS, and other diseases, and several projects are underway to apply information from fundamental studies to targeted inhibitor design.
For more information, see my group on the Structural Biology Section home page.
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Selected Publications
1. Lindwasser OW, Smith WJ, Chaudhuri R, Yang P, Hurley JH, Bonifacino JS A Diacidic Motif in HIV-1 Nef is a Novel Determinant of Binding to AP2. J Virol, 2007. [Full Text/Abstract]
2. Munshi UM, Kim J, Nagashima K, Hurley JH, Freed EO An Alix fragment potently inhibits HIV-1 budding: characterization of binding to retroviral YPXL late domains. J Biol Chem(282): 3847-55, 2007. [Full Text/Abstract]
3. Fujii K, Hurley JH, Freed EO Beyond Tsg101: the role of Alix in ''ESCRTing'' HIV-1. Nat Rev Microbiol(5): 912-6, 2007. [Full Text/Abstract]
4. Chaudhuri R, Lindwasser OW, Smith WJ, Hurley JH, Bonifacino JS Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol(81): 3877-90, 2007. [Full Text/Abstract]
5. Hierro A, Rojas AL, Rojas R, Murthy N, Effantin G, Kajava AV, Steven AC, Bonifacino JS, Hurley JH Functional architecture of the retromer cargo-recognition complex. Nature(449): 1063-7, 2007. [Full Text/Abstract]
6. Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell(129): 485-98, 2007. [Full Text/Abstract]
7. Lee S, Joshi A, Nagashima K, Freed EO, Hurley JH Structural basis for viral late-domain binding to Alix. Nat Struct Mol Biol(14): 194-9, 2007. [Full Text/Abstract]
8. Prag G, Watson H, Kim YC, Beach BM, Ghirlando R, Hummer G, Bonifacino JS, Hurley JH The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Dev Cell(12): 973-86, 2007. [Full Text/Abstract]
9. Leonard TA, Hurley JH Two kinase family dramas. Cell(129): 1037-8, 2007. [Full Text/Abstract]
10. Hurley JH Membrane binding domains. Biochim Biophys Acta (1761): 805-11, 2006. [Full Text/Abstract]
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