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 Thursday, August 21, 2008 Volume 21   Number 8
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
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10 Years of the Genomics & Health Weekly Update
In 1998, the National Office of Public Health Genomics (NOPHG) at the CDC established the Genomics & Health Weekly Update and published the first

issue in July 1998. The Weekly Update helps to address the need for credible, timely, and publicly accessible information about genomics that professionals and the public can use to make decisions. Read more

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blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
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 Upcoming Events

August issue of the Genetics and Public Policy Center August newsletter non-gov warning icon

August issue of the American Society of Human Genetics newsletter non-gov warning icon

Genetic Alliance Weekly Bulletin non-gov warning icon

Genomics Announcements
 

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2007 Oregon BRFSS results on family history and heart disease and stroke are now available.
   
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The National Institutes of Health announces two new funding opportunities for genomics translation research:
   
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HuGENet™ What's New
August 2008


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

New insights into the regulation of PTEN tumor suppressor function, non-gov warning icon Medical News Today, August 21

Prototype test for predicting clinical outcome for melanoma patients..., non-gov warning icon Medical News Today, August 16

Those at risk for breast cancer are having mastectomies, non-gov warning icon Newsday, August 20

Breast cancer: Who's at risk, non-gov warning icon WMTW.com, August 15

Applegate Underwent Breast Removal to Stop Cancer, non-gov warning icon ABC News, August 19 Colon cancer linked to unequal gene activity, non-gov warning icon Medical News Today, August 15

Cancer signatures uncovered, non-gov warning icon News-Medical.Net, August 17

 

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Cardiovascular Disease

New study highlights importance for women to know their risk of heart disease, non-gov warning icon Market Watch, August 14

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Ethical, Legal and Social Issues (ELSI)

Medicine tailored to your genome, non-gov warning icon iol.co.za, August 20 

Personal genomics: Access denied, non-gov warning icon Technology Review, August 19

California licenses 2 companies to offer gene services, non-gov warning icon The New York Times,  August 19 

Tougher laws needed to protect your genetic privacy, non-gov warning icon Scientific American, August 18

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Family History

Ask the Mayo Clinic: Family health history can help identify potential risks, non-gov warning icon Seattlepi.com, August 17

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Genetic Testing

 

UC Davis M.I.N.D. Institute researchers to begin widespread newborn screening for Fragile X Syndrome, non-gov warning icon Medical.Net, August 20

Testing genes, solving little, non-gov warning icon The New York Times, August 16

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Infectious Disease

Personalized immunotherapy to fight HIV/AIDS, non-gov warning icon EurekAlert, August 15

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Mental Health

U-M seeks participants to discover genetics behind epilepsy, non-gov warning icon Checkbiotech, August 21

Study links genetic variants to bipolar disorder, non-gov warning icon Reuters Health, August 18

Blood vessel gene influences brain size, Yale researchers find, non-gov warning icon Medical News Today, August 19

Largest study of its kind implicates gene abnormalities in bipolar disorder, non-gov warning icon NIH News, August 17

Facial structures, brain abnormalities studied to reveal formula for detection of autism, non-gov warning icon Medical News Today, August 19

 

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Obesity

Oxford "Obesity-Gene" group launches target for obesity researchers, non-gov warning icon Medical News Today, August 15

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Other News

Gene behind serious statin risk, non-gov warning icon WebMD, August 20

Top killers you can neutralize, non-gov warning icon Red Orbit, August 17

NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use, non-gov warning icon NIH News, August 20

Study on what links genetics and disease, non-gov warning icon The Star, August 15

Scientists discover how mutation in the copper-regulating protein ATP7B causes Wilson disease, non-gov warning icon News-Medical.Net, August 19

Flawed gene boosts liver disease risk, non-gov warning icon Political Gateway, August 14

Suppressing disease-causing genes is now within reach, non-gov warning icon Medical News Today, August 19

 
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Genomics in Scientific Literature
Featured Item

Multiple Novel Prostate Cancer Predisposition Loci Confirmed by an International  Study: The PRACTICAL Consortium
Kote-Jarai Z, et al.
Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):2052-61


 General Articles

Dissecting the Nutrigenomics, Diabetes, and Gastrointestinal Disease Interface: From Risk Assessment to Health Intervention
Ferguson LR
OMICS 2008 Aug

Effect of cytokine and pharmacogenomic genetic polymorphisms in transplantation
Girnita DM, et al.
Curr Opin Immunol 2008 Aug

Effect of ABCA1 mutations on risk for myocardial infarction
Iatan I, et al.
Curr Atheroscler Rep 2008 Oct;10(5):413-26

Stroke genetics--focus on PDE4D gene
Munshi A & Kaul S
Int J Stroke 2008 Aug;3(3):188-92

Will we ever find the genes for addiction?
Buckland PR
Addiction 2008 Aug

Learning of your parent's BRCA mutation during adolescence or early adulthood: a  study of offspring experiences
Bradbury AR, et al.
Psychooncology 2008 Aug

The Role of the BRCA2 Gene in Susceptibility to Prostate Cancer Revisited
Ostrander EA & Udler MS
Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):1843-8

Genetics of ischaemic stroke - single gene disorders
Flossmann E
Int J Stroke 2006 Aug;1(3):131-9

Molecular genetics of myocardial infarction
Yamada Y, et al.
Genomic Med 2008 Aug

Hereditary hemochromatosis: time for targeted screening
Phatak PD, et al.
Ann Intern Med 2008 Aug;149(4):270-2

Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer
Lo SH, et al.
Proc Natl Acad Sci U S A 2008 Aug


 Family History

The effect of a school-based educational intervention on gender differences in reported family cancer history
Quillin JM, et al.
J Cancer Educ 2008;23(3):180-5

Prevalence of self-perceived allergic diseases and risk factors in Italian adolescents
Brescianini S, et al.
Pediatr Allergy Immunol 2008 Aug

 

 Genetic Testing

Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers
Rebbeck TR & Domchek SM
Breast Cancer Res 2008 Jul;10(4):108

Phenotype Comparison of MLH1 and MSH2 Mutation Carriers in a Cohort of 1,914 Individuals Undergoing Clinical Genetic Testing in the United States
Kastrinos F, et al.
Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):2044-51

Carrier screening for cystic fibrosis in US genetic testing laboratories: a survey of laboratory directors
Kaufman D, et al.
Clin Genet 2008 Aug

Utility of an exon 14 BslI polymorphism for improved genetic diagnosis of hemophilia A in Indian population
Mukundan P, et al.
Prenat Diagn 2008 Aug

Does thrombophilia testing help in the clinical management of patients?
Middeldorp S & van Hylckama Vlieg A
Br J Haematol 2008 Aug

 Genome Wide

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Ferreira MA, et al.
Nat Genet 2008 Aug

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Unoki H, et al.
Nat Genet 2008 Aug

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Yasuda K, et al.
Nat Genet 2008 Aug

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending August 20, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: August 21, 2008 (archived document)
Content Source: National Office of Public Health Genomics