• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
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Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology Burton PR, et al. Int J Epidemiol 2008 Aug

Ordering Molecular Genetic Tests and Reporting Results. Practices in Laboratory and Clinical Settings
Lubin IM, et al.
J Mol Diagn 2008 Jul

Genetics of sarcoidosis
Grunewald J
Curr Opin Pulm Med 2008 Sep;14(5):434-9

The new genetics and chronic obstructive pulmonary disease
Kalsheker N & Chappell S
COPD 2008 Aug;5(4):257-64

A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
Gayan J, et al.
BMC Genomics 2008 Jul;9(1):360

Molecular epidemiology, cancer-related symptoms, and cytokines pathway
Reyes-Gibby CC, et al.
Lancet Oncol 2008 Aug;9(8):777-85

Do inflammatory cytokine genes confer susceptibility to diabetic nephropathy?
Maeda S
Kidney Int 2008 Aug;74(4):413-5

Genetic susceptibility to bladder cancer with an emphasis on gene-gene and gene-environmental interactions
Horikawa Y, et al.
Curr Opin Urol 2008 Sep;18(5):493-8

Management of women who have a genetic predisposition for breast cancer
Jatoi I & Anderson WF
Surg Clin North Am 2008 Aug;88(4):845-61

Hereditary diffuse gastric cancer: prophylactic surgical oncology implications
Lynch HT, et al.
Surg Clin North Am 2008 Aug;88(4):759-78

N-acetyltransferases as markers for asthma and allergic/atopic disorders
Batra J & Ghosh B
Curr Drug Metab 2008 Jul;9(6):546-53

Influence of polymorphic N-acetyltransferases on non-malignant spontaneous disorders and on response to drugs
Ladero JM
Curr Drug Metab 2008 Jul;9(6):532-7

Polymorphisms of human N-acetyltransferases and cancer risk
Agundez JA
Curr Drug Metab 2008 Jul;9(6):520-31

Interethnic and Intraethnic Variability of NAT2 Single Nucleotide Polymorphisms
Garcia-Martin E
Curr Drug Metab 2008 Jul;9(6):487-97

Thrombosis and inflammatory bowel disease-the role of genetic risk factors
Tsiolakidou G & Koutroubakis IE
World J Gastroenterol 2008 Jul;14(28):4440-4

Angiotensin-converting enzyme gene in Alzheimer's disease
Yang YH & Liu CK
Tohoku J Exp Med 2008 Aug;215(4):295-8

The genetics of castration-resistant prostate cancer: what can the germline tell  us?
Sharifi N, et al.
Clin Cancer Res 2008 Aug;14(15):4691-3

Genetic causality in schizophrenia and bipolar disorder: out with the old and in  with the new
Porteous D
Curr Opin Genet Dev 2008 Jul

Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error rate and power
Matthews AG, et al.
Stat Appl Genet Mol Biol 2008;7:Article23

The implications of gene-environment interactions in depression: will cause inform cure?
Uher R
Mol Psychiatry 2008 Aug

Family history: value-added information in assessing cardiac health
McNeill JA, et al.
AAOHN J 2008 Jul;56(7):297-305; quiz 306-7

Family history of myocardial infarction is an independent risk factor for venous  thromboembolism - the Tromso study
Braekkan SK, et al.
J Thromb Haemost 2008 Jul

Exercise training has greater effects on insulin sensitivity in daughters of patients with type 2 diabetes than in women with no family history of diabetes
Barwell ND, et al.
Diabetologia 2008 Jul

Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis
Bergquist A, et al.
Clin Gastroenterol Hepatol 2008 Aug;6(8):939-43

 

Short-chain acyl-CoA dehydrogenase (SCAD) deficiency: An examination of the medical and neurodevelopmental characteristics of 14 cases identified through newborn screening or clinical symptoms
Waisbren SE, et al.
Mol Genet Metab 2008 Aug

Genetic testing for BRCA1: effects of a randomised study of knowledge provision on interest in testing and long term test uptake; implications for the NICE guidelines
Hall J, et al.
Fam Cancer 2008 Aug

Genetic testing for cancer susceptibility
Calzone KA & Soballe PW
Surg Clin North Am 2008 Aug;88(4):705-21

Explaining Behavior Change after Genetic Testing: The Problem of Collinearity between Test Results and Risk Estimates
Fanshawe TR, et al.
Genet Test 2008 Jul

Identification of loci associated with schizophrenia by genome-wide association and follow-up
O'Donovan MC, et al.
Nat Genet 2008 Jul

Genome-wide association study of rheumatoid arthritis in the Spanish population:  KLF12 as a risk locus for rheumatoid arthritis susceptibility
Julia A, et al.
Arthritis Rheum 2008 Jul;58(8):2275-86

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
Graham RR, et al.
Nat Genet 2008 Aug

Large recurrent microdeletions associated with schizophrenia
Stefansson H, et al.
Nature 2008 Jul

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending August 6, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Musculoskeletal System and Connective Tissue
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page