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 Thursday, May 3, 2007     Volume 18   Number 18  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
  This weekly update provides information about the impact of human genetic research on disease prevention & public health. open mailbox for email deliveryGet email updates
Spotlight
Sections
senior citizens in a field teacher with college students

National Stroke Month
Stroke is the third leading cause of death and a major cause of disability
in the United States. Read more.

National Mental Health Month
Mental disorders are real, disabling health conditions that have an immense impact on individuals and families in the United States. Read more.
 > View Current Update
blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotFamily History
blue dotGenetic Testing
blue dotHuGE Articles
blue dotBack Issues


 
CDC Announcements
 
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New EGAPP Website Released non-gov warning icon
This month, CDC's Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Project released its new website, which highlights the activities of the independent, non-federal EGAPP Working Group, providing links to evidence reports commissioned by the EGAPP Working Group on specific genetic tests, and free access to EGAPP Working Group recommendation statements as they become available.
   
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New Web Page Added to National Office of Public Health Genomics Website
A new Genomics & Your Health web page has been added to CDC’s National Office of Public Health Genomics (NOPHG) website that provides spotlights on national health observance. These spotlights provide information about specific diseases and the role of genetics and family history.
   
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May Issue of Family History and Your Health non-gov warning iconPDF icon (328KB)
This issue highlights National Osteoporosis Awareness and Prevention Month, and provides information on osteoporosis and family history and genetics. The newsletter is developed by the Public Health Genomics Program in the Michigan Department of Community Health.
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Genomics In The News [ back to top ]
  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
Featured item
“More type 2 diabetes genes discovered”  non-gov warning icon
(Apr 27) Medical NewsToday reports, “Several teams of scientists this week report discovering more genes linked to Type 2 Diabetes and describe the achievement as bringing science closer to understanding the genetics of the origins and progress of this modern disease.”

“Biomarker discovery bodes well for better cancer diagnostics”  non-gov warning icon
(May 2) News-Medical.Net reports, “While new findings from Ohio State University scientists suggest a genetic marker that could help distinguish between chronic pancreatitis and pancreatic cancer and gauge who will do well with cancer treatment, a pharmacologist at the Kimmel Cancer Center at Jefferson in Philadelphia sees the discovery as much more.”

“Inflammatory system genes linked to cognitive decline after heart surgery” non-gov warning icon
(May 2) Science Daily reports, “Variants of two genes involved in the inflammatory system appear to protect patients from suffering a decline in mental function following heart surgery.”

“Gene therapy used in pioneering eye operation”    non-gov warning icon
(May 2) Japan Today reports, “Doctors in Britain have carried out an operation which is the first attempt to cure a sight disorder using gene therapy, they said Tuesday.”

“The X chromosome: The supermom that's inside of us all”    non-gov warning icon
(May 2) The International Herald Tribune reports, “As May dawns and the mothers among us excitedly anticipate the clever e-cards that we soon will be linking to and the overpriced brunches that we will somehow end up paying for, the following job description may ring a familiar note:”

“Gene discovery may improve pancreatic cancer diagnosis, treatment”    non-gov warning icon
(May 1) Health Scout reports, “Scientists say they can use small bits of genetic material called microRNA to spot key differences between chronic pancreatitis and pancreatic cancer, aiding in earlier diagnosis for the lethal malignancy.”

“Lung cancer risk cut by gene, experts claim”    non-gov warning icon
(May 1) Sky News reports, “Scientists are a step closer to finding out why some people get cancer.”

“New technology detects functional genes”    non-gov warning icon
(May 1) The Post Chronicle reports, “The GeoChip created by U.S. scientists is described as a genomics-based tool that can detect functional genes and processes in a microbial community.”

“New understanding of how histone and DNA methylation communicate”    non-gov warning icon
(May 1) News-Medical.Net reports, “In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.”

“Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level”    non-gov warning icon
(Apr 30) EurekAlert! reports, “Alzheimer's disease, Parkinson's disease, type 2 diabetes, the human version of mad cow disease, and other degenerative diseases are more closely related at the molecular level than scientists realized, a team reports this week in an advanced online publication of the journal Nature.”

“Rheumatoid arthritis and the impact of genetic factors on mortality”    non-gov warning icon
(Apr 30) Science Daily reports, “A chronic autoimmune disease, rheumatoid arthritis (RA) is marked by inflammation that takes a progressive toll on not only the joints, but also various organs and the whole body.”

“Scientists find new agent to fight genetic disorders -- Zorro-Locked Nucleic Acid”    non-gov warning icon
(Apr 30) EurekAlert! reports, “A study to appear in the June 2007 issue of The FASEB Journal describes a new agent, called "Zorro-LNA," which has the potential to stop genetic disorders in their tracks.”

“Students consider impact of genetics”    non-gov warning icon
(Apr 30) Rocky Mount Telegram reports, “After weeks of studying the chemical aspects of DNA, Rocky Mount High School students, joined by researchers from the University of North Carolina-Chapel Hill, debated the legal, ethical and societal implications of the body's blueprint.”

“Commercialization of novel ud gene-repair technology”    non-gov warning icon
(Apr 29) News-Medical.Net reports, “OrphageniX Inc., a new biotechnology company founded by University of Delaware researchers, has been established in Wilmington to develop and commercialize UD-patented technologies for repairing genes that cause rare, hereditary diseases such as sickle cell anemia and spinal muscular atrophy.”

“Researchers find clear genetic risk factors for type 2 diabetes”    non-gov warning icon
(Apr 29) News-Medical.Net reports, “Scientists from the Broad Institute of Harvard and MIT, Lund University and Novartis have announced the discovery of three unsuspected regions of human DNA that contain clear genetic risk factors for type 2 diabetes, and another that is associated with elevated blood triglycerides.”

“Genetic differences may explain why many Asian women who never smoked develop lung cancer”    non-gov warning icon
(Apr 29) News-Medical.Net reports, “Analysis of three genetic mechanisms that cause non-small cell lung cancer might explain why East Asians respond better than other ethnic groups to a certain type of chemotherapy, a team led by UT Southwestern Medical Center researchers has found.”

“New hereditary breast cancer gene discovered”    non-gov warning icon
(Apr 29) Medical NewsToday reports, “A new hereditary breast cancer gene has been discovered by scientists at the Lundberg Laboratory for Cancer Research and the Plastic Surgery Clinic at the Sahlgrenska Academy in Sweden.”

“Genes could boost arthritis patients' death risk”    non-gov warning icon (last accessed 2/2008)
(Apr 27) Medline Plus reports, “Rheumatoid arthritis patients with certain genetic traits may be at increased risk of early death from heart disease or cancer, British researchers report.”

“Researchers discover first gene associated with idiopathic scoliosis”    non-gov warning icon
(Apr 27) Medical NewsToday reports, “Researchers at Texas Scottish Rite Hospital for Children (TSRHC), one of the nation's leading pediatric centers for research and the treatment of orthopaedic conditions, have identified the first gene -- CHD7 -- associated with idiopathic scoliosis (I.S.), the most common spinal deformity in children.”

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Genomics in Scientific Literature
featured item

Genetics of Ischaemic Stroke among Persons of Non-European Descent: A Meta-Analysis of Eight Genes Involving approximately 32,500 Individuals
Ariyaratnam R, et al.
PLoS Med 2007 Apr;4(4):e131

Genetics of congenital diaphragmatic hernia
Scott DA
Semin Pediatr Surg 2007 May;16(2):88-93

Is FCRL3 a New General Autoimmunity Gene?
Chistiakov DA & Chistiakov AP
Hum Immunol 2007 May;68(5):375-83

Genetics of inflammation in age-related atherosclerosis: its relevance to pharmacogenomics
Grimaldi MP, et al.
Ann N Y Acad Sci 2007 Apr;1100:123-31

Genetics of Healthy Aging in Europe: The EU-Integrated Project GEHA (GEnetics of Healthy Aging)
Franceschi C, et al.
Ann N Y Acad Sci 2007 Apr;1100:21-45

Estimating the odds ratios of Crohn disease for the main CARD15/NOD2 mutations using a conditional maximum likelihood method in pedigrees collected via affected family members
Pascoe L, et al.
Eur J Hum Genet 2007 Apr

The Current Status of Medical Genetics Instruction in U.S. and Canadian Medical Schools
Thurston VC, et al.
Acad Med 2007 May;82(5):441-5

Application of pharmacogenomic strategies to the study of drug-induced birth defects
Leeder JS & Mitchell AA
Clin Pharmacol Ther 2007 Apr;81(4):595-9

Toward understanding the genetic basis of neural tube defects
Kibar Z, et al.
Clin Genet 2007 Apr;71(4):295-310

Genes, maternal smoking, and the offspring brain and body during adolescence: Design of the Saguenay Youth Study
Pausova Z, et al.
Hum Brain Mapp 2007 Apr

Racialized genetics and the study of complex diseases: the thrifty genotype revisited
Paradies YC, et al.
Perspect Biol Med 2007 Spring;50(2):203-27

Cystic Fibrosis: A Review of Epidemiology and Pathobiology
Strausbaugh SD & Davis PB
Clin Chest Med 2007 Jun;28(2):279-88

Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy
Witt H, et al.
Gastroenterology 2007 Apr;132(4):1557-73

An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)
Chenevix-Trench G, et al.
Breast Cancer Res 2007 Apr;9(2):104

Effects of dopamine D2 receptor gene polymorphisms on smoking cessation: abstinence and withdrawal symptoms
Munafo MR & Johnstone EC
Pharmacogenomics 2007 May;8(5):513-7

How can the emerging patient-centric health records lower costs in pharmacogenomics?
Shabo Shvo A
Pharmacogenomics 2007 May;8(5):507-11

Pharmacogenetics and stomach cancer: an update
Toffoli G & Cecchin E
Pharmacogenomics 2007 May;8(5):497-505

Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing
Crawford DC, et al.
Pharmacogenomics 2007 May;8(5):487-96

What do dopamine transporter and catechol-o-methyltransferase tell us about attention deficit-hyperactivity disorder? Pharmacogenomic implications
Levy F
Aust N Z J Psychiatry 2007 Jan;41(1):10-6

Family History
 In The News

No news articles this week.

 

 In The Scientific Literature

Hereditary factors in multiple primary malignancies associated with lung cancer
Haraguchi S, et al.
Surg Today 2007;37(5):375-8

A risk model for prediction of lung cancer
Spitz MR, et al.
J Natl Cancer Inst 2007 May;99(9):715-26

Genetic Testing
 In The News

“EuroGentest draft recommendations on genetic counseling”    non-gov warning icon
(May 2) The PHG Foundation reports, “EuroGentest is a European network of excellence that aims to improve and harmonise standards for laboratory genetic testing services in Europe.”

 

 In The Scientific Literature

Israeli nurses and genetic information disclosure
Barnoy S & Tabak N
Nurs Ethics 2007 May;14(3):280-94

Privacy and equality in diagnostic genetic testing
Nyrhinen T, et al.
Nurs Ethics 2007 May;14(3):295-308

A Comparative Study of Five Technologically Diverse CFTR Testing Platforms
Johnson MA, et al.
J Mol Diagn 2007 Apr

Recent advances in newborn screening
Wilcken B
J Inherit Metab Dis 2007 Apr;30(2):129-33

Newborn screening for cystic fibrosis
Rock MJ
Clin Chest Med 2007 Jun;28(2):297-305

Surveillance for familial breast cancer: Differences in outcome according to BRCA mutation status
Moller P, et al.
Int J Cancer 2007 Apr

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 2, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last reviewed: May 3, 2007 (archived document)
Content Source: National Office of Public Health Genomics