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 Thursday, February 1, 2007     Volume 18   Number 5  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention and public health. open mailbox for email deliveryGet email updates
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A CDC-sponsored evidence report on Testing for CYP450 Polymorphisms in Adults With Non-Psychotic Depression Treated With SSRIs has been released by the Agency for Healthcare Research & Quality (AHRQ).

CDC Announcements
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Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and Endometrial Cancer: A HuGE Review you will need a free Acrobat reader to view this file (143KB)
(January 2007)
   
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Mayo Clinic Research Shows 35 Percent Of 49 Young People Who Died Suddenly And Inexplicably Had Genetic Heart Defects” This reference links to a non-governmental website
(Jan 31) Medical News Today reports, “In 49 young people who died suddenly and inexplicably at an average age of 14, conventional autopsies found no cause of death.”

“Gene therapy tourists” This reference links to a non-governmental website
(Feb 1) Newstatesman reports, “Desperation drove Richard Weissenborn to China.”

“Genetic fingerprints identify brain tumors' origins” This reference links to a non-governmental website
(Feb 1) Washigton University in St. Louis reports, “Genetic fingerprints that reveal where a brain cell came from remain distinct even after the cell becomes a brain tumor, an international coalition of scientists will report in the February 1 issue of Cancer Research.”

“The perplexing issues of cancer before 40” This reference links to a non-governmental website
(Jan 31) International Herald Tribune reports, “In July 2005, Jeff Carenza and his girlfriend were enjoying a getaway weekend in Miami when food poisoning landed them both in the hospital.”

“UCLA Researchers Discover Genes Linked To Lymphoma, Opening Way For New Targeted
Drugs”
 This reference links to a non-governmental website
(Jan 31) Medical News Today reports, “Lymphoma is a blood cancer that affects more than 60,000 Americans each year.”

“Uncovering Natural Products From Mystery 'Orphan Genes'” This reference links to a non-governmental website
(Jan 30) Science Daily reports, “Microorganisms have a proven track record for producing powerful molecules useful in antibiotics, as anticancer agents, and in treating human diseases.”

“Study finds genes that predict transplant rejection” This reference links to a non-governmental website
(Jan 30) CTV.ca reports, “Canadian researchers believe they have come up with a way to predict whether transplants from specific bone marrow donors are likely to trigger rejection -- an advance that could help doctors weed out so-called "dangerous donors'' and cut back on immune suppressant drugs for some transplant recipients.”

“A Form Of The Alcohol Dehydrogenase Gene May Protect Afro-Trinidadians From Developing Alcoholism” This reference links to a non-governmental website
(Jan 30) Medical News Today reports, “The ADH1B*3 allele may also increase the risk for liver disease if individuals choose to drink.”

“Salmonella survives better in stomach due to altered DNA” This reference links to a non-governmental website
(Jan 29) Netherlands Organization for Scientific Research reports, “Since 1995 there has been a considerable increase in the number of infections with a specific type of Salmonella bacteria transmitted via food.”

“Let your genes become your diet expert” This reference links to a non-governmental website
(Jan 29) The Siasat Daily reports, “You do not need to make sudden changes in your diet any more because of any hereditary disease.”

“Autoimmune Disease Breakthrough Gained By Identification Of 30 Errant Genes” This reference links to a non-governmental website
(Jan 29) Medical News Today reports, “A report in the January issue of Nature magazine announces that one more step in understanding what may cause the body to attack itself in its war against autoimmune disease has been discovered by researchers at the Massachusetts Institute of Technology's Whitehead Institute, says the Autoimmune Related Diseases Association (AARDA), a national nonprofit patient advocacy organization.”

“50% of Americans have gene that affects how body burns sugar” This reference links to a non-governmental website
(Jan 28) News-Medical.Net reports, “A recent study by a Saint Louis University researcher confirms findings that about half of the U.S. population has a version of a gene that causes them to metabolize food differently, putting them at greater risk of developing diabetes.”

“RNA used to turn on genes to alleviate disease” This reference links to a non-governmental website
(Jan 28) News-Medical.Net reports, “A new technique that employs RNA, a tiny chemical cousin of DNA, to turn on genes could lead to therapeutics for conditions in which nudging a gene awake would help alleviate disease, researchers at UT Southwestern Medical Center say.”

“Genetic Study To Understand Linkage Between Lead Exposure And Children's Intellectual Development In India” This reference links to a non-governmental website
(Jan 27) Medical News Today reports, “BioServe, a leading provider of rapid, economical processing and analyses of genomic content from biological samples, has been selected to work with scientists from the Harvard and University of Michigan Schools of Public Health on a landmark study aimed at understanding how genetics and environmental lead pollution interact to affect children's intellectual and behavioral functioning.”

“Both Genetics And Dopaminergic Neurotransmission Have A Role In Delirium Tremens” This reference links to a non-governmental website
(Jan 26) Science Daily reports, “Alcohol-dependent individuals have a five to 10 percent lifetime risk of developing delirium tremens (DT) following alcohol withdrawal. DT is characterized by a clouding of consciousness, mental confusion or disorientation, and is often accompanied by hallucinations and agitation.”

“Scientists Are Uncovering New Meaning In The Genetic Code” This reference links to a non-governmental website
(Jan 25) Medical News Today reports, “The genetic code may seem like a recipe for life scripted with cold precision, but scientists are discovering that the code reads more like a poem in which syllables within words can bear hidden and critical meaning, according to an article scheduled for the Jan. 22 issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine.”

“Genes play bigger role than environment in anorexia”  This reference links to a non-governmental website (last accessed 3/2007)
(Jan 25) Reuters Health reports, “There is no scientific evidence to back up recent statements by fashion supermodel Gisele Bundchen that unsupportive families can cause the eating disorder anorexia nervosa, experts say.”

“A form of the alcohol dehydrogenase gene may protect Afro-Trinidadians from developing alcoholism” This reference links to a non-governmental website
(Jan 25) EurekAlert! reports, “The ADH1B*3 allele may also increase the risk for liver disease if individuals choose to drink.”

“Genetic Risk Factor For Parkinson's Found” This reference links to a non-governmental website
(Jan 25) The Post Chronicle reports, “A U.S.-led study suggests many Chinese Parkinson's disease victims carry a genetic mutation that originated from a common ancestor about 4,800 years ago.”

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Genomics in Scientific Literature
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Current thinking on genetics of chronic obstructive pulmonary disease
Molfino NA
Curr Opin Pulm Med 2007 Mar;13(2):107-13

Young people's experiences of growing up in a family affected by Huntington's disease
Forrest Keenan K, et al.
Clin Genet 2007 Feb;71(2):120-9

Genetic polymorphisms related to delirium tremens: a systematic review
van Munster BC, et al.
Alcohol Clin Exp Res 2007 Feb;31(2):177-84

Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Kotsopoulos J, et al.
Breast Cancer Res Treat 2007 Jan

Genomics and the cardiac surgeon
Bullard MK, et al.
J Card Surg 2007 Jan-2007 Feb;22(1):83-6

Molecular genetics of bipolar disorder and depression
Kato T
Psychiatry Clin Neurosci 2007 Feb;61(1):3-19

Human genetic data from a data protection law perspective
Schulte In den Baumen T
Bundesgesundheitsblatt Gesundheitsforschung  2007 Jan

The National Down Syndrome Project: design and implementation
Freeman SB, et al.
Public Health Rep 2007 Jan-2007 Feb;122(1):62-72

Human genetics of infectious diseases: a unified theory
Casanova JL & Abel L
EMBO J 2007 Jan

Genetics of congenital heart diseases in syndromic and non-syndromic patients: new advances and clinical implications
Piacentini G, et al.
J Cardiovasc Med (Hagerstown) 2007 Jan;8(1):7-11

Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics
Linehan WM, et al.
Clin Cancer Res 2007 Jan;13(2):671s-9s

Gene polymorphisms and susceptibility to coronary artery disease
Shah SH
Pediatr Blood Cancer 2007 Jan

Genetic polymorphisms and disease prevention
Mahoney MC
Pediatr Blood Cancer 2007 Jan

Development of a web-based query tool for quality assurance of clinical molecular genetic test results
McGinniss MJ, et al.
J Mol Diagn 2007 Feb;9(1):95-8

Pharmacogenetics and oncology treatment for breast cancer
Marsh S & McLeod HL
Expert Opin Pharmacother 2007 Feb;8(2):119-27

Complex trait genetics of refractive error
Young TL, et al.
Arch Ophthalmol 2007 Jan;125(1):38-48

Family History
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“Medical Mystery: Genetic Secret to a Long Life?” This reference links to a non-governmental website (last accessed 2/2008)
(Jan 30) abc News reports, “In the foothills of the Italian Alps is a tiny village that may hold a clue to a medical mystery that has challenged researchers for centuries.”

“Scientists link paternal gene, autism” This reference links to a non-governmental website
(Jan 26) Science Daily reports, “A study of autism in India has found that a gene passed on by fathers may be at least a contributing factor.”

A comparison of community, clinician, and patient preferences for naming a cancer-related mutation Wakefield C, et al.
Clin Genet 2007 Feb;71(2):140-7

Family History of Dementia in 1st-Degree Relatives of Patients with Dementia Onset before Age 70 Years
Bader C, et al.
Psychiatr Prax 2007 Jan;34(1 Suppl):114-6

Heritability of ischaemic stroke in women compared with men: a genetic epidemiological study
Touze E & Rothwell PM
Lancet Neurol 2007 Feb;6(2):125-33

Multicenter Comparative Multimodality Surveillance of Women at Genetic-Familial High Risk for Breast Cancer (HIBCRIT Study): Interim Results
Sardanelli F, et al.
Radiology 2007 Jan

Genetic Testing
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“Genetic tests may bring hope, inspire fear” This reference links to a non-governmental website
(Jan 29) CNN.com reports, “Genetic testing can help predict many diseases and one day may help prevent them, but privacy concerns and fears of abuse could derail the technology's potential.”

“Malays more prone to genetic form of eye cancer” This reference links to a non-governmental website (last accessed 2/2008)
(Jan 29) New Straits Times Online reports, “It is estimated that at least one in 15,000 children here are prone to develop a genetic form of eye cancer.”

“Gene 'could predict ADHD drug reaction'” This reference links to a non-governmental website
(Jan 29) ninemsn reports, “A genetic test may help stop hyperactive children being overdosed on controversial psycho-stimulant drugs like Ritalin, Australian research suggests.”

“Gene Therapy Of AIDS” This reference links to a non-governmental website
(Jan 29) Medical News Today reports, “Specialists of the V.A. Engelgardt Institute of Molecular Biology, Russian Academy of Sciences, and the "Vector" Main Research Center of Virology and Biotechnology created and tested on the cell culture three genetic structures capable to suppress reproduction of human immunodeficiency virus (HIV-1) in human cells.”

“Digene Faces Challenge Of Convincing Physicians To Administer HPV Test, Baltimore Sun Reports” This reference links to a non-governmental website
(Jan 25) Medical News Today reports, “About 19% of the 35 million U.S. women who meet the criteria to receive Digene's human papillomavirus test were given the test last year, the company recently said, the Baltimore Sun reports.”

“Drug strategy makes cancer genes get lost in translation” This reference links to a non-governmental website
(Jan 25) EurekAlert! reports, “A new strategy for fighting cancer aims to make its genes get lost in translation, according to a report in the January 26, 2007, issue of the journal Cell, published by Cell Press.”

“Calculated Risk: Scientists Discover Genetic Risk Factor For Smoking-linked Head And Neck Cancer” This reference links to a non-governmental website
(Jan 25) Science Daily reports, “A simple blood test may be able to identify those most at risk for developing head and neck cancer as a result of smoking.”

Cystic fibrosis diagnosed after 2 months of age leads to worse outcomes and requires more therapy Sims EJ, et al.
Pediatrics 2007 Jan;119(1):19-28

A survey of preventive measures among BRCA1 mutation carriers from Poland
Gronwald J, et al.
Clin Genet 2007 Feb;71(2):153-7

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 31, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Click here for more information about upcoming events.

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New This Week

European Human Genetics Conference 2007 This reference links to a non-governmental website
June 16-19, 2007 ~ Nice, France

Quantitative Genetics And Genomics  This reference links to a non-governmental website
February 18-23, 2007 ~ Ventura, CA

   
 

Personalized Medicine & Molecular Diagnostics: Legal, Regulatory and Ethical Perspectives This reference links to a non-governmental website
March 2, 2007 ~ Tempe, AZ

   
 

Genomics Disorders 2007  This reference links to a non-governmental website
March 21-23, 2007 ~ Hinxton, UK

   
New This Week Pharmacogenetics & Human Genome Variation  This reference links to a non-governmental website
May 21, 2007 ~ Montreal, Canada
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Let's Go Surfing
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World Health Organization: The Genomic Resource Centre This reference links to a non-governmental website
This resource base has been developed to provide information and build awareness on human genomics a new and rapidly developing science.

AETMIS  This reference links to a non-governmental website
The Agence d’évaluation des technologies et des modes d’intervention en santé (AETMIS, the Québec government agency responsible for health services and technology assessment) is an independent organization that reports to Québec's Minister of Health and Social services.

Guilford Genomic Medicine Initiative  This reference links to a non-governmental website
The Guilford Genomic Medicine Initiative (GGMI) is a demonstration project to introduce genomic medicine services into the community health care setting in Guilford County. The initial phase will involve the development of tools to obtain a patient's family history, to assess their risk for common cancers and blood clotting disorders, and to provide appropriate counseling and surveillance.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: February 1, 2007 (archived document)
Content Source: National Office of Public Health Genomics