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 Thursday, May 25, 2006     Volume 16   Number 21  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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HuGE Published Literature Database
The HuGE Published Literature Database (HuGE Pub Lit) is a searchable, online knowledge base of published, population-based epidemiologic studies of human genes. The database contains links to PubMed articles and can be searched by gene, disease, interacting factor, type of study design or analysis, or any combination of terms in these categories. Read the scientific articleThis reference links to a non-governmental websitein the American Journal of Epidemiology that provides an overview of the database.

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CDC Announcements
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CDC's 2006 National Health Promotion Conference
September 12-14, 2006 ~ Atlanta, GA
A joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) as related to birth defects and developmental disabilities, chronic disease, and genomics. Registration is now open.

   
CDC sponsored material New HuGE Review
The epidemiology of medium chain acyl-CoA dehydrogenase deficiency: An update you will need a free Acrobat reader to view this file (111KB)
Scott Grosse et al. Genetics in Medicine (April 2006)
   
CDC sponsored material New HuGE Review
XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer you will need a free Acrobat reader to view this file (80KB)
Maurizio Manuguerra et al. American Journal of Epidemiology Advance Access (May 2006)
   
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Integrating the Evidence on Gene-Disease Association:Methods and applications of HuGE systematic reviewsThis reference links to a non-governmental website 
November 6-8, 2006 ~ Cambridge, UK
Apply now, space is limited.
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Researchers link two more genes to sudden infant death syndrome”This reference links to a non-governmental website
(May 19) EurekAlert! reports, “Recent discoveries at Mayo Clinic added two more cardiac genes to the list of potential links to sudden infant death syndrome (SIDS), increasing the possibility that genetic defects of the heart may cause up to 15 percent of SIDS cases.”

“Proteus Mirabilis Will Give Up Its Genetic Secrets At ASM Meeting”This reference links to a non-governmental website
(May 25) Medical News Today reports, “Scientists now have inside information to use in the fight against Proteus mirabilis - a nasty bacterium that can cause kidney stones, as well as hard-to-treat urinary tract infections.”

“A Gene Predisposing To Pituitary Tumors Identified”This reference links to a non-governmental website
(May 25) Medical News Today reports, “A recent Finnish study identifies a low-penetrance gene defect which predisposes carriers to intracranial tumors called pituitary adenomas.”

“Genes Discovered That Allow Gum Disease Bacterium To Invade Arteries”This reference links to a non-governmental website
(May 25) Medical News Today reports, “Researchers have identified the genes in gum-disease bacteria that allow them to invade and infect human arterial cells, offering one possible explanation for a perceived connection between gum disease and heart disease.”

“Toward a less expensive, more convenient treatment of Gaucher's disease”This reference links to a non-governmental website
(May 24) EurekAlert! reports, “Prospects for eventual development of a less costly and more convenient treatment for Gaucher's disease have brightened with new research findings reported in the May issue of ACS Chemical Biology.”

“Immune Signals Of Variations Of A Single Gene Linked To More Severe Crohn's Disease”This reference links to a non-governmental website
(May 24) Medical News Today reports, “Building on previous evidence supporting the theory that the pathophysiology of Crohn's Disease is altered by genetic variation, recent studies have found that the combination of immune signals given by three variants of a single candidate gene affects the severity of the disease, particularly among Ashkenazi Jews.”

“New Genetic Test For Breast Cancer”This reference links to a non-governmental website
(May 24) Medical News Today reports, “Researchers at Montefiore Medical Center are leading a nationwide clinical trial to determine whether a new genetic test can be used to personalize treatment for early-stage breast cancer.”

“Gene Expression Becomes Heterogeneous With Age In Humans And Rats”This reference links to a non-governmental website
(May 24) Medical News Today reports, “In a study of the effects of aging on gene expression, researchers have found that variation in gene expression among individuals tends to increase with age.”

“MRI cost-effective for some women at high-risk of breast cancer”This reference links to a non-governmental website
(May 23) News-Medical.Net reports, “A computer model simulation suggests that adding breast MRI screening may be cost-effective for women of certain ages who carry BRCA1 and BRCA2 gene mutations, according to a study in the May 24/31 issue of JAMA: The Journal of the American Medical Association.”

“New technique to deliver insulin genes to pancreas”This reference links to a non-governmental website
(May 23) News-Medical.Net reports, “Researchers at Baylor University Medical Center at Dallas and the Baylor Research Institute have developed a novel technique to deliver insulin genes to the pancreas, the organ that produces the body's insulin.”

“USPTO Genetic Sequence Database, USGENE, Available On STN International”This reference links to a non-governmental website
(May 22) Medical News Today reports, “SequenceBase Corporation and FIZ Karlsruhe are pleased to announce that a preview of The USPTO Genetic Sequence Database, USGENE will be shown for the first time to attendees at the Patent Information Users Group Meeting (PIUG) in Minneapolis, Minnesota on May 21, 2006.”

“Genetic Basis For Premature Ovarian Failure Identified”This reference links to a non-governmental website
(May 22) Medical News Today reports, “Researchers have successfully identified several genes associated with Premature Ovarian Failure (POF) or premature menopause, enabling carriers to make informed choices with regards to family planning.”

“Vegan diet lowers odds of having twins”This reference links to a non-governmental website (last accessed 3/2007)
(May 22) Reuters Health via Peoples's Daily Online reports, “Women who eat a vegan diet -- a strict vegetarian diet that excludes all animal products including milk -- are one fifth as likely as other women to have twins, a U.S. researcher reported on Saturday.”

“Researchers Find Genetic Link in Bone Cancer”This reference links to a non-governmental website
(May 21) Yahoo! News reports, “The discovery of a gene called MET may explain the development of osteosarcoma, a bone cancer found mainly in adolescents, according to a team of Italian scientists. The gene will also provide a target for researchers looking for treatments or a cure for this disease.”

“MDCH Recognizes May 14-20 As National Women?s Health Week”This reference links to a non-governmental website
(May 19) Michigan.gov reports, “As National Women’s Health Week comes to a close, the Michigan Department of Community Health is asking minority women to increase their use of available health services to combat health disparities.”

“Is There A Risk Of Transmitting Genetic Disorders To Babies Conceived Through Fertility Procedures?”This reference links to a non-governmental website
(May 19) Medical News Today reports, “As medical technology continues to advance, fertility procedures such as in-vitro fertilization and donor insemination are becoming more commonplace.”

“H5N1 human cluster raises questions about genetics”This reference links to a non-governmental website
(May 19) CTV.ca reports, “A large cluster of human cases of H5N1 avian flu in Indonesia is raising questions about whether genetic susceptibility explains why some people exposed to the dangerous virus become infected while many more do not.”

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Genomics in Scientific Literature
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Cost-effectiveness of screening BRCA1/2 mutation carriers with breast magnetic resonance imaging
Plevritis SK, et al. JAMA 2006 May;295(20):2374-84

The quest for genetic determinants of human longevity: challenges and insights
Christensen K, et al.
Nat Rev Genet 2006 Jun;7(6):436-48

Statistical power of association using the extreme discordant phenotype design
Zhang G, et al.
Pharmacogenet Genomics 2006 Jun;16(6):401-13

A New Definition of Genetic Counseling: National Society of Genetic Counselors' Task Force Report
Resta R, et al.
J Genet Couns 2006 May

Cost-effectiveness of screening BRCA1/2 mutation carriers with breast magnetic resonance imaging
Plevritis SK, et al. JAMA 2006 May;295(20):2374-84

Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey
Dogan AU, et al.
Cancer Res 2006 May;66(10):5063-8

Genetic epidemiological studies of preterm birth: Guidelines for research
Pennell CE, et al.
Am J Obstet Gynecol 2006 May

Congenital long QT syndromes: clinical features, molecular genetics and genetic testing
Ching CK & Tan EC
Expert Rev Mol Diagn 2006 May;6(3):365-74

Challenges of SNP genotyping and genetic variation: its future role in diagnosis and treatment of cancer
Bernig T & Chanock SJ
Expert Rev Mol Diagn 2006 May;6(3):319-31

AmpliChip CYP450 Test: personalized medicine has arrived in psychiatry
de Leon J
Expert Rev Mol Diagn 2006 May;6(3):277-86

A practical approach to genetic testing for von Willebrand disease
Pruthi RK
Mayo Clin Proc 2006 May;81(5):679-91

Variations on a Gene: Rare and Common Variants in ABCA1 and Their Impact on HDL Cholesterol Levels and Atherosclerosis
Brunham LR, et al.
Annu Rev Nutr 2006 May

Depressed-type (0-IIc) colorectal neoplasm in patients with family history of first-degree relatives with colorectal cancer: A cross-sectional study
Iwasaki J, et al.
World J Gastroenterol 2006 May;12(19):3082-7

Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
Levy D, et al.
BMC Genet 2006 May;7(1):30

Evaluating coverage of genome-wide association studies
Barrett JC & Cardon LR
Nat Genet 2006 May

Evaluating and improving power in whole-genome association studies using fixed marker sets
Pe'er I, et al.
Nat Genet 2006 May

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 24, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week Tenth Meeting of the Secretary’s Advisory Committee on Genetics, Health, and Society This reference links to a non-governmental website
June 26-27, 2006 ~ Bethesda, MD
 

9th Annual Meeting of the American Society of Gene Therapy

   
New this week Genomic Perspectives to Host Pathogen InteractionsThis reference links to a non-governmental website (last accessed 2/2008)
September 7-10, 2006 ~ Cold Spring Harbor, NY
   
  British Society for Human Genetics (BSHG) Annual Conference This reference links to a non-governmental website
September 18-20, 2006 ~ York, UK
   
New this week 11th Annual Short Course on Genetic Approaches to Complex Heart, Lung, and Blood DiseasesThis reference links to a non-governmental website (last accessed 2/2008)
October 19-28, 2006 ~ Bar Harbor, ME
   
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Let's Go Surfing
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Ethical legal and social issues in stem cell research and therapy This reference links to a non-governmental website
“The Cambridge Genetics Knowledge Park presents a critical summary of the major debates and policy responses relating to ES cell research, drawing attention to some of the challenges posed by conflicting moral values in an era of global scientific endeavor and to provide an analysis of the key ethical and regulatory implications for stem cell therapy.”

EGAPP Meeting Summary, February 2006

Centre for Law & GeneticsThis reference links to a non-governmental website
The mission of the Centre is to provide excellence in research for the benefit of the Australian and International communities into the legal and ethical issues arising from the developments in genetic technology and to propose effective and equitable means for developing, applying and benefit-sharing of this technology.

Human Genetics Advisory Committee This reference links to a non-governmental website
The Human Genetics Advisory Committee (HGAC) has been established to provide on-going advice to the Australian government on high-level technical and strategic issues in human genetics, and on the social, ethical and legal implications of human genetics and related technologies.

 

 

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This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: May 25, 2006 (archived document)
Page last updated: November 6, 2007
Content Source: National Office of Public Health Genomics