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 Thursday, July 27, 2006     Volume 17   Number 4  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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Welcome to the National Office of Public Health Genomics
As of July 24, 2006, the CDC has changed the name of our office to the National Office of Public Health Genomics.

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CDC Announcements
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Factor XIII Val34Leu Variant Is Protective against Venous Thromboembolism
Philip S. Wells et al.
Am Jour Epidem 2006 Jul 15;164(2):101-9
   
CDC sponsored material The path from genome-based research to population health: Development of an international public health genomics network you will need a free Acrobat player to view this file
Burke W, Khoury M et al.
Genet Med 2006 Jul;8(7):451-8
   
CDC sponsored material What is the clinical utility of genetic testing? you will need a free Acrobat player to view this file
Scott D. Grosse and Muin J. Khoury
Genetics in Medicine 2006 Jul 8(7): 448-50
   
CDC sponsored material

Obesity and Genetics: A Public Health Perspective (PHP)
This updated PHP examines obesity as it relates to genes and the environment and includes helpful resources for a healthy weight, journal articles, and presentations.

   
CDC sponsored material Storage and use of residual dried blood spots from state newborn screening programs
Olney RS, et al.
J Pediatr 2006 May;148(5):618-22
   
CDC sponsored material

New HuGE Case Studies

CDC sponsored material HuGE What's New
July 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“Scientists say they've found second genetic code in DNA”
(July 25) HeraldToday.com reports, “Researchers believe they have found a second code in DNA in addition to the genetic code.”

“How genes affect impact of alcohol on individuals”  This reference links to a non-governmental website
(July 27) The Guardian reports, “Recent studies published in the August issue of Alcoholism: Clinical & Experimental Research have shown the relationship between genes and impact of alcohol on individuals.”

“New genetic findings add to understanding of OCD” This reference links to a non-governmental website
(July 26) EurekAlert! reports, “Studies of DNA from OCD patients and their relatives lead two teams of researchers to consistent genetic association.”

“New insights into how cells repair damaged DNA” This reference links to a non-governmental website
(July 26) News-Medical.Net reports, “Cancer researchers have discovered that a recently identified protein critical for repairing damaged genes uses an unusual mechanism to keep its repairs accurate.”

“Viral genetic differences are possible key to HIV dementia” This reference links to a non-governmental website
(July 25) EurekAlert! reports, “HIV mutation is clue to why only some people develop AIDS dementia”

“How can identical twins be genetically different?” This reference links to a non-governmental website
(July 25) EurekAlert! reports, “U-M scientists find new genes linked to rheumatoid arthritis that are expressed differently in genetically identical twins.”

“Drug approved to treat rare genetic disease” 
(July 24) Wired News reports, “The first drug treatment for the rare but potentially deadly inherited disease Hunter Syndrome was approved Monday by the Food and Drug Administration.”

“Cell Protection Mechanism Points To Therapies To Prevent Heart Attacks And Strokes” This reference links to a non-governmental website
(July 23) Science Daily reports, “An understanding of how two genes cooperate to protect aortic muscle cells points to new therapies to treat arteriosclerosis, the major cause of heart attack and stroke, a study by Queen’s University researchers concludes.”

“Gene Variant Increases Risk Of Type 2 Diabetes; But Healthy Lifestyle Changes Reduce Genetic
Risk”
 This reference links to a non-governmental website
(July 23) Science Daily reports, “Researchers have confirmed that a gene variant confers susceptibility to type 2 diabetes in participants of the Diabetes Prevention Program (DPP), a large clinical trial in adults at increased risk for developing type 2 diabetes. “

“UNBC Hosts Second Western Canada Conference on RNA Genetic Research” This reference links to a non-governmental website
(July 22) UNBC reports, “50 researchers – primarily from BC and Alberta – will be meeting at UNBC on July 24-25 to present some of their findings on the frontier of genetic research.”

“UCSF genetics pioneer Y.W. Kan earns Lifetime Achievement Award” This reference links to a non-governmental website
(July 21) UCSF reports, “Yuet Wai Kan, MD, DSc, an internationally recognized leader in the field of human genetics, was honored Thursday (July 20) with a Lifetime Achievement Award by the Society of Chinese Bioscientists in America.”

“UCI receives $2.9 million grant to start 'LifeChips' program” This reference links to a non-governmental website
(July 20) Today@UCI reports, “UC Irvine has been awarded nearly $2.9 million over five years to create a new graduate program in which students will combine the practices of engineering, physical sciences, biological sciences and medicine to produce small-scale technologies that benefit human health.”

“Whether in mice or men, all cells age the same, Stanford study finds” This reference links to a non-governmental website
(July 20) EurekAlert! reports, “We can dye gray hair, lift sagging skin or boost lost hearing, but no visit to the day spa would be able to hide a newly discovered genetic marker for the toll that time takes on our cells.”

“U of M researchers discover genetic key to treating deadly fungal infections” This reference links to a non-governmental website
(July 20) EurekAlert! reports, “University of Minnesota researchers have discovered how a prevalent fungal pathogen that causes 10,000 deaths per year in the United States overcomes the effects of antifungal drugs by duplicating a section of one of its chromosomes.”

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Genomics in Scientific Literature
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Family history in colorectal cancer surveillance strategies
Hakama M
Lancet 2006 Jul;368(9530):101-3

Family History, and Impact on Clinical Presentation and Prognosis, in a Population-based Breast Cancer Cohort from the Stockholm County
Margolin S, et al.
Fam Cancer 2006 Jul

Epidermal growth factor receptor mutation testing in the care of lung cancer patients
Sequist LV, et al.
Clin Cancer Res 2006 Jul;12(14):4403s-8s

Case-control studies in the genomic era: a clinician's guide
Healy DG
Lancet Neurol 2006 Aug;5(8):701-7

Mitochondrial DNA involvement in human longevity
Santoro A, et al.
Biochim Biophys Acta 2006 Jun

Recent advances in the studies of genetic polymorphisms in diabetic retinopathy
Wang N & Xu X
Zhonghua Yan Ke Za Zhi 2006 Jun;42(6):563-6

Accurate description of the phenotype: the clinician's contribution to the clarification of genotype-phenotype correlations
Mehes K & Kosztolanyi G
Orv Hetil 2006 Jun;147(23):1059-61

Genetic testing for von Willebrand disease: the canadian experience
James P & Lillicrap D
Semin Thromb Hemost 2006 Jul;32(5):546-52

Association of Family History of Specific Cancers With a Younger Age of Onset of Pancreatic Adenocarcinoma
McWilliams RR, et al.
Clin Gastroenterol Hepatol 2006 Jul

Genetic susceptibility testing for Alzheimer disease: Motivation to obtain information and control as precursors to coping with increased risk
Gooding HC, et al.
Patient Educ Couns 2006 Jul

Breast cancer screening behaviors among African American women with a strong family history of breast cancer
Halbert CH, et al.
Prev Med 2006 Jul

Risk Reduction Behaviors and Provider Communication Following Genetic Counseling and BRCA1 Mutation Testing in an African American Kindred
Kinney AY, et al.
J Genet Couns 2006 Jul

Predictive Testing of Eighteen Year Olds: Counseling Challenges
Gaff CL, et al.
J Genet Couns 2006 Jul

Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a genetic polymorphism
Guiducci S, et al.
Ann N Y Acad Sci 2006 Jun;1069:10-9

A randomized controlled trial of a decision aid for women at increased risk of ovarian cancer
Tiller K, et al.
Med Decis Making 2006 Jul-2006 Aug;26(4):360-72

The geneticization of diagnostics
Stempsey WE
Med Health Care Philos 2006;9(2):193-200

Genetic association studies in cancer: good, bad or no longer ugly?
Savage SA & Chanock SJ
Hum Genomics 2006 Jun;2(6):415-21

Functional single nucleotide polymorphism-based association studies
Carlton VE, et al.
Hum Genomics 2006 Jun;2(6):391-402

From DNA to RNA to disease and back: the 'central dogma' of regulatory disease variation
Stranger BE & Dermitzakis ET
Hum Genomics 2006 Jun;2(6):383-90

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending July 26, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New This Week

From Gene to Gender This reference links to a non-governmental website (last accessed 2/2008)
August 31- September 2, 2006 ~ Luebeck, Germany

 

10th International Conference on Alzheimer's Disease and Related Disorders This reference links to a non-governmental website
August 15-20, 2006 ~ Madrid, Spain

   
  Gene Therapy for Inherited Deficiencies: Advances and Safety Issues
September 18-19, 2006 ~ Bethesda, MD
   
  International Congress of Immunogenomics and Immunomics This reference links to a non-governmental website (last accessed 2/2008)
October 8-12, 2006 ~ Budapest, Hungary
   
  The American Society of Human Genetics 56th Annual Meeting This reference links to a non-governmental website
October 9-13, 2006 ~ New Orleans, Lousiana
   
  Genomics Momentum 2006 This reference links to a non-governmental website
November 9, 2006 ~ Rotterdam, Netherlands
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Let's Go Surfing
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Canada’s Genome Science Centre This reference links to a non-governmental website
The Genome Sciences Centre has a primary mandate to deploy resources and technology of a high-throughput genome mapping and DNA sequencing lab to decrypt the genetic code, specifically to advance cancer research, diagnosis and treatment.

Who am I? This reference links to a non-governmental website
The Science Museum in the UK comprised a presentation including genes and human behaviour, human origins, genes and your health, studying genes and DNA and genes and inheritance.

Molecular Phenotyping to Accelerate Genomic Epidemiology This reference links to a non-governmental website (last accessed 2/2008)
MolPAGE is a 4-year project, funded by the European Union FP6 programme to the value of 12 million Euros that brings together a consortium of 18 leading academic institutions, biotechnology and pharmaceutical companies.

Beyond the Genome ... Beyond the Individual: Genomics and Public Health
National Society of Genetic Counselors Short Course 2006
November 9-10, 2006 ~ Nashville, TN

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: July 27, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics