Publications: Methodology Archive

• A public health approach to pharmacogenomics and gene-based diagnostics (335KB)
  Davis R and Khoury MJ 
  Pharmacogenomics (April 2006)

• Quantifying the health benefits of genetic tests: The importance of a population perspective
  Khoury MJ, Jones K, Grosse SD
  Genet Med. (March 2006)

• How many Genes Underlie the Occurrence of Common Complex Diseases in the Population?  (374KB)
  Yang Q et al.
  International J Epidemiology (2005)

• Do we need Genomic Research for the Prevention of Diseases with Environmental Causes?(87KB)
  Khoury MJ et al.
  Am J Epidemiol (May 2005)

• Design Considerations for a Potential United States Population-Based Cohort
  (1.12MB)
  The proposal for a U.S. cohort study of genes, environment and heath (2004)

•  Comparison of Prospective and Retrospective Methods for Haplotype Inference in Case-Control Studies
  Satten GA, Epstein MP
  Genet Epidemiol (November 2004)

• The Case for a Global Human Genome Epidemiology Initiative
  Article by Muin J. Khoury (September 2004)

• The Emergence of Epidemiology in the Genomics Age
  (105KB)
  Khoury MJ et al.
  Int J Epidemiol (August 2004)

• An Epidemiologic Assessment of Genomic Profiling for Measuring Susceptibility to Common Diseases and Targeting Interventions
  Khoury MJ  
  Genet Med 2004 Jan-Feb; 6(1):38-47

• Population Screening in the Age of Genomic Medicine
  Muin J. Khoury
  New Engl Jour Med, 2003 348(1):50-38

• Mendelian Randomisation: A New Spin or Real Progress?
  A commentary by Julian Little, PhD and Muin J. Khoury
  Lancet 2003; 9388:(930-931)

• Improving the Prediction of Complex Diseases by Testing for Multiple Disease-Susceptibility Genes
  Yang Q, et. al. 
  Am J Hum Genet, 2003 Mar;72(3):636-49

• Informative Missingness in Genetic Association Studies: Case-Parent Designs
  Allen AS et al.
  Am J Hum Genet. 2003 Mar;72(3):671-80. Epub 2003 Feb 14

• On the Use of Population Attributable Fraction to Determine Sample Size for Case-Control Studies of Gene-Environment Interaction
  Yang et al.
  Epidemiology 2003 Mar;14(2):161-7

• Inference on Haplotype Effects in Case-Control Studies Using Unphased Genotype Data
  MP. Epstein and. GA. Satten
  Am J Hum Genet 2003;73:1316

• DNA Banking for Epidemiologic Studies: A Review of Current Practices
  Steinberg K, et al.
  Epidemiology 2002 May;13(3):246-54

• Reporting, Appraising, and Integrating Data On Genotype Prevalence and Gene-Disease Associations
  Little J et al.
  Am J Epidemiol (2002)

• Commentary:  Facing the Challenge of Gene-Environment Interaction: The Two-by-Four Table and Beyond (56KB)
  Lorenzo D. Botto and Muin J. Khoury 
  Am J Epidemiol (May 2001)

• Accounting for Unmeasured Population Substructure in Case-Control Studies of Genetic Association Using a Novel Latent-Class Model (226KB)
  Satten GA, Flanders WD, Yang Q.
  Am J Hum Genet 2001 Feb;68(2):466-77

• New Estimator of the Genotype Risk Ratio for Use in Case-Parental Control Studies
  (838KB)
  W. Dana Flanders, Fengzhu Sun, and Quanhe Yang
  American Journal of Epidemiology 2001;154,3:259-263

• On the Use of Population-based Registries in the Clinical Validation of Genetic Tests for Disease Susceptibility (1.2MB)
  Genetics in Medicine (June 2000)

• Case-Only Design to Measure Gene-Gene Interaction
  Quanhe Yang, et al. 
  Epidemiology (March 1999)

• Comparative Genomics and Host Resistance against Infectious Diseases
  S. T. Qureshi et al.
  Emerging Infectious Diseases (1999)

• Exploring Gene-Gene Interactions in the Etiology of Neural Tube Defects
  Lorenzo D. Botto and Pierpaolo Mastroiacovo
  Clin Genet 1998;53:456-459 (1998)

• The Future of Genetic Studies of Complex Human Diseases: An Epidemiologic Perspective
  Epidemiology (1998)

• Genetic and Epidemiologic Approaches to the Search for Gene-Environment Interaction: the Case of Osteoporosis
  Muin J. Khoury
  American Journal of Epidemiology, 1998;147:1-2

• DNA Banking in Epidemiologic Studies
  Epidemiologic Reviews. (1997)

• Evolving Methods in Genetic Epidemiology III. Gene-Environment Interaction in Epidemiologic Research
  Quanhe Yang and Muin J. Khoury
  Epidemiologic Reviews 1997;19:33-43

• Genetic Epidemiology and the Future of Disease Prevention and Public Health
  Muin J. Khoury
  Epidemiologic Reviews (1997)

• Sample Size Requirements in Case-only Designs to Detect Gene-environment Interaction
  Quanhe Yang, Muin J. Khoury, and W. Dana Flanders.
  Am J Epidemiol 1997;146 (9): 713-720.

• Epidemiologic Evaluation of the Use of Genetics to Improve the Predictive Value of Disease Risk Factors
  Khoury MJ and Wagener DW
  Am J Hum Genet (1995)