• An exploratory test for an excess of significant findings
  John P. A. Ioannidis and Thomas A. Trikalinos
  Clinical Trials 2007; 4(3):245-53.

• Claims of sex differences: an empirical assessment in genetic associations
  Nikolaos A. Patsopoulos, Athina Tatsioni, and John P. A. Ioannidis
  JAMA 2007; 298(8):880-93.

• The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases
  A. Cecile J. W. Janssens, Ramal Moonesinghe, Quahne Yang, Ewout W. Steyerberg, Cornelia M. van Duijn, and Muin J. Khoury,
  Genetics in Medicine 2007; 9(8):528-35.

• Genetic and molecular epidemiology
  John P. A. Ioannidis
  Journal of Epidemiology and Community Health 2007; 61(9):757-8.

In September, a formal partnership between the journal, Archives of Dermatology, and HuGENet™ was announced.

• Dermatology and the human genome: An epidemiologic approach
  Marta Gwinn and Muin J. Khoury
  Archives of Dermatology, September 2007

• Archives of Dermatology constitutes the eleventh academic journal to collaborate with HuGENet™
  > View list of collaborating journals

One new HuGE Review has been posted on the HuGENet™ Web site since the last issue of ‘What's New':

• Joint effects of the N-Acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: A literature-based systematic HuGE Review and evidence synthesis by Simon Sanderson, Georgia Salanti, and Julian Higgins from the University of Cambridge
  American Journal of Epidemiology, August 2007

The following systematic reviews examined the epidemiologic evidence between genes and diseases using a quantitative approach and were added to PubMed in August:

• Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?

• UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters.

• A meta-analysis of association between C677T polymorphism in themethylenetetrahydrofolate reductase gene and hypertension.

• The transcription factor 7-like 2 (TCF7L2) gene is associated with type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.

• Association study and meta-analysis of Alzheimer's disease risk and presenilin-1 intronic polymorphism.

• Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis.

• MTHFR C677T polymorphism and osteoporotic fractures.

• Meta-analysis of APOE genotype and subarachnoid hemorrhage: clinical outcome and delayed ischemia.

• Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and panic disorder: a systematic review and meta-analysis.

• Differences in the association between apolipoprotein E genotype and mortality across populations.

• Role of the c-344t aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes.

• Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease.

• The PAI-1 4G/5G gene polymorphism and ischemic stroke: an association study and meta-analysis.

• Analysis of candidate genes on chromosomes 5q and 19p in celiac disease.

• Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis.

> List of completed HuGE Reviews
> List of HuGE Review topics under development

Handbook for Authors of New HuGE Reviews
HuGENet™ released the first edition of the HuGENet™ Handbook of Systematic
Reviews ((165KB)) in March 2006. All new HuGE reviews should follow the guidance in this document.

As of September 17, 2007, the HuGE Published Literature database contains 29,429 research referencing 2,960 genes,and 1,904 health outcomes/diseases. Both epidemiologic studies and review articles can be found in the database which includes 61 HuGE Reviews and 559 meta-analyses.

Provides link to non-governmental sites and does not necessarily represent the  views of the Centers for Disease Control and Prevention.