HuGENet™ is proud to announce the deployment of an integrated, searchable knowledge base of genetic associations and human genome epidemiology, the
HuGE Navigator, designed to assist researchers working in the field of Human Genome Epidemiology. These tools can be used to determine additional research questions, find collaborators, and evaluate gene-disease associations. Please visit the main page of the HuGE Navigator for more information.

Cumulative Evidence of Genetic Associations

Assessment of cumulative evidence on genetic associations: interim guidelines. HuGE review authors are strongly encouraged to use these guidelines in conducting HuGE reviews and meta analyses

One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia.

The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.

The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6,861 patients and 9,270 controls reveals no evidence for association.

The tryptophan hydroxylase 1 (TPH1) gene and risk of schizophrenia: A moderate-scale case-control study and meta-analysis.

Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease.

Has Toll-Like Receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association.

Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease.

Hemochromatosis genotypes and risk of 31 disease endpoints: Meta-analyses including 66,000 cases and 226,000 controls.

MDM2 SNP309 and cancer risk: A combined analysis.

Studies in 3,523 Norwegians (HUNT2) and meta-analysis in 11,571 subjects indicate that variants in the HNF4A P2 region are associated with type 2 diabetes in Scandinavians.

SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population.

Heterogeneity in meta-analyses of genome-wide association investigations.

Role of genetic polymorphisms in ACE and TNF-alpha gene in sarcoidosis: a meta-analysis.

Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study.

Hereditary nonpolyposis colorectal cancer: diagnostic strategies and their implications.

Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients.

Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus.

Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias.

• Search for HuGE Reviews in the HuGE Navigator
• Search for systematic reviews in the HuGE Navigator

Genome Wide Association Studies

The Framingham Heart Study 100,000 single nucleotide polymorphisms resource

A common variant of HMGA2 is associated with adult and childhood height in the general population.

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies.

A search for variants associated with young-onset type 2 diabetes in American Indians in a 100k genotyping array.

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: Evidence for replication from diabetes-related quantitative traits and from independent populations.

A 100k genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets.

A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer.

• Search for genome wide association studies in the HuGE Navigator

HuGENet Publications

Heterogeneity in meta-analyses of genome-wide association investigations.

Turning the pump handle: evolving methods for integrating the evidence on gene-disease association.

Will genomics widen or help heal the schism between medicine and public health?

Assessment of cumulative evidence on genetic associations: interim guidelines.

• View all HuGENet Publications
  

As of October 5, 2007, the HuGE Navigator contains 29,843 research studies, referencing 3,015 genes,and 1,913 health outcomes/diseases. Both epidemiologic studies and review articles can be found in the database which includes 61 HuGE Reviews and 573 meta-analyses.

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