In November HuGENet UK will host a short course on how to integrate the evidence on genetic association using systematic reviews and methods of meta analysis. For more information, including a list of the faculty and topics to be covered, visit the HuGENet short course webpage. Please contact:

Jane Lane
HuGENet UK Coordinating Centre
Public Health Genetics Unit
Strangeways Research Laboratory
Worts Causeway
Cambridge CB1 8RN

Tel: +44 1223 742003
Email: jane.lane@srl.cam.ac.uk

Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature Database
Lin BK et al. Am J Epidemiol (in press)
This article describes the HuGE Published Literature database, http://www.cdc.gov/genomics/search/aboutHPLD.htm.

Make it HuGE: human genome epidemiology reviews, population health, and the IJE (162KB)
Smith GD et al. Int. J Epidemiol (in press)
The International Journal of Epidemiology will now consider HuGE reviews for publication, especially those addressing “Mendelian randomization.”

Commentary: Grading the credibility of molecular evidence for complex diseases (183KB)
Ioannidis JP. Int J Epidemiol, March 2006

Obstacles and opportunities in meta-analysis of genetic association studies (366KB)
G. Salanti et al. Genetics in Medicine, January 2005

• View all HuGENet™ Publications and learn how to submit a paper for the HuGENet™ website

The HuGENet™ staff has compiled a list of funding opportunities for population-based research on the prevalence of human genetic variation, the association between genetic variants and human diseases, gene-gene or gene-environment interaction, or the evaluation of genetic tests for screening and prevention.  Items are pulled from the National Institutes of Health Office of Extramural Research.  Additional information and application details can be found by clicking on the respective links.  New program announcements or requests for applications will be posted in future issues of the “What's New?” as they become available.

New listings:

Integrating Lung Genetics and Genomics in Human Populations (R01) (PA-06-370)
National Heart, Lung, and Blood Institute

Notice to Announce Availability of Biomaterials, Phenotyping Information, and Genotyping Data from the NIMH Genetics Initiative for Whole Genome Association Studies (NOT-MH-06-108)
National Institute of Mental Health  

View Entire List of Funding Opportunities for Population-Based Research in Human Genome Epidemiology.

Numerous collaborative networks of investigators are undertaking meta-analyses of literature and of individual-level data on gene-disease associations. HuGENet™ is building a global network of such networks to create a resource for information, offer methodological support, promote sound design and standardization of analytical practices, generate inclusive overviews of fields-at-large, facilitate rapid confirmation of findings, and avoid duplication of effort. Visit the HuGENet™ Network of Networks Website to learn more about this initiative and for information about how to join.

As of May 1, 2006, the HuGENetä website contains 21,070 research studies indexed in the HuGE Published Literature database, referencing 2,336 genes, 784 factors (personal or environmental), and 2,517 health outcomes/diseases.  Both epidemiologic studies and review articles can be found in the database which includes 273 meta-analyses and 90 pooled analyses.  Please see the GDPInfo Summary of Contents for more details.

Note: The count of health outcomes indexed in the database is based on a query that groups similar outcomes according to ICD-9 codes.  This figure is different from the total numbers of records listed in the Genomics and Disease Prevention Information system (GDPInfo) portal Health Topics A-Z. 

Search for specific HuGENet™ content using the Advanced Search feature in the GDPInfo query tool.

Provides link to non-governmental sites and does not necessarily represent the views of the  Centers for Disease Control and Prevention.